Brigham Hartley
Brigham Hartley
Principal Scientist, NYSCF
Verified email at
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An efficient platform for astrocyte differentiation from human induced pluripotent stem cells
TCW Julia, M Wang, AA Pimenova, KR Bowles, BJ Hartley, E Lacin, ...
Stem cell reports 9 (2), 600-614, 2017
Dysregulation of miRNA-9 in a subset of schizophrenia patient-derived neural progenitor cells
A Topol, S Zhu, BJ Hartley, J English, ME Hauberg, N Tran, ...
Cell reports 15 (5), 1024-1036, 2016
High-content screening in hPSC-neural progenitors identifies drug candidates that inhibit Zika virus infection in fetal-like organoids and adult brain
T Zhou, L Tan, GY Cederquist, Y Fan, BJ Hartley, S Mukherjee, ...
Cell stem cell 21 (2), 274-283. e5, 2017
Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains
GE Hoffman, BJ Hartley, E Flaherty, I Ladran, P Gochman, DM Ruderfer, ...
Nature communications 8 (1), 1-15, 2017
The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain
Y Jiang, YHE Loh, P Rajarajan, T Hirayama, W Liao, BS Kassim, ...
Nature genetics 49 (8), 1239, 2017
Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells
SM Ho, BJ Hartley, TCW Julia, M Beaumont, K Stafford, PA Slesinger, ...
Methods 101, 113-124, 2016
Characterization of molecular and cellular phenotypes associated with a heterozygous CNTNAP2 deletion using patient-derived hiPSC neural cells
IS Lee, CMB Carvalho, P Douvaras, SM Ho, BJ Hartley, LW Zuccherato, ...
NPJ schizophrenia 1 (1), 1-5, 2015
In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain
Z Chatterton, BJ Hartley, MH Seok, N Mendelev, S Chen, M Milekic, ...
Epigenetics & chromatin 10 (1), 1-11, 2017
Increased abundance of translation machinery in stem cell–derived neural progenitor cells from four schizophrenia patients
A Topol, JA English, E Flaherty, P Rajarajan, BJ Hartley, S Gupta, ...
Translational psychiatry 5 (10), e662-e662, 2015
Evaluating synthetic activation and repression of neuropsychiatric-related genes in hiPSC-derived NPCs, neurons, and astrocytes
SM Ho, BJ Hartley, E Flaherty, P Rajarajan, R Abdelaal, I Obiorah, ...
Stem Cell Reports 9 (2), 615-628, 2017
Neural organoids for disease phenotyping, drug screening and developmental biology studies
BJ Hartley, KJ Brennand
Neurochemistry international 106, 85-93, 2017
Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models
J Xu, BJ Hartley, P Kurup, A Phillips, A Topol, M Xu, C Ononenyi, ...
Molecular psychiatry 23 (2), 271-281, 2018
Lmx1a Allows Context‐Specific Isolation of Progenitors of GABAergic or Dopaminergic Neurons During Neural Differentiation of Embryonic Stem Cells
CM Nefzger, CT Su, SA Fabb, BJ Hartley, SJ Beh, WR Zeng, JM Haynes, ...
Stem Cells 30 (7), 1349-1361, 2012
Expression-based drug screening of neural progenitor cells from individuals with schizophrenia
B Readhead, BJ Hartley, BJ Eastwood, DA Collier, D Evans, R Farias, ...
Nature communications 9 (1), 1-11, 2018
Dopaminergic differentiation of schizophrenia hiPSCs
BJ Hartley, N Tran, I Ladran, K Reggio, KJ Brennand
Molecular psychiatry 20 (5), 549-550, 2015
Resolving the unconventional mechanisms underlying RXFP1 and RXFP2 receptor function
BJ Hartley, DJ Scott, GE Callander, TN Wilkinson, DE Ganella, CK Kong, ...
Annals of the New York Academy of Sciences 1160 (1), 67-73, 2009
Altered mTORC1 signaling in multipotent stem cells from nearly 25% of patients with nonsyndromic autism spectrum disorders
AM Suzuki, K Griesi-Oliveira, COF Machado, E Vadasz, EC Zachi, ...
Molecular psychiatry 20 (5), 551-552, 2015
Human pluripotent stem cell derived midbrain pitx3egfp/w neurons: A versatile tool for pharmacological screening and neurodegenerative modeling
B Watmuff, BJ Hartley, CPJ Hunt, SA Fabb, CW Pouton, JM Haynes
Frontiers in Cellular Neuroscience 9, 104, 2015
Dysregulation of miRNA-9 in a subset of schizophrenia patient-derived neural progenitor cells. Cell Rep 15: 1024–1036
A Topol, S Zhu, BJ Hartley, J English, ME Hauberg, N Tran, ...
CrossRef PubMed PubMedCentral, 2016
Zinc-finger nuclease enhanced gene targeting in human embryonic stem cells
BJ Hartley, SA Fabb, BAL Finnin, JM Haynes, CW Pouton
JoVE (Journal of Visualized Experiments), e51764, 2014
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