| Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation R Huang, MA Holbert, MK Tarrant, S Curtet, DR Colquhoun, BM Dancy, ... Journal of the American Chemical Society 132 (29), 9986-9987, 2010 | 132 | 2010 |
| A selective phenelzine analogue inhibitor of histone demethylase LSD1 P Prusevich, JH Kalin, SA Ming, M Basso, J Givens, X Li, J Hu, MS Taylor, ... ACS chemical biology 9 (6), 1284-1293, 2014 | 117 | 2014 |
| The role of epigenomics in personalized medicine MM Kronfol, MG Dozmorov, R Huang, PW Slattum, JL McClay Expert review of precision medicine and drug development 2 (1), 33-45, 2017 | 74 | 2017 |
| Design, synthesis, and kinetic analysis of potent protein N-terminal methyltransferase 1 inhibitors G Zhang, SL Richardson, Y Mao, R Huang Organic & biomolecular chemistry 13 (14), 4149-4154, 2015 | 61 | 2015 |
| Structural basis for substrate recognition by the human N-terminal methyltransferase 1 C Dong, Y Mao, W Tempel, S Qin, L Li, P Loppnau, R Huang, J Min Genes & Development 29 (22), 2343-2348, 2015 | 46 | 2015 |
| Kinetic mechanism of protein N-terminal methyltransferase 1 SL Richardson, Y Mao, G Zhang, P Hanjra, DL Peterson, R Huang Journal of Biological Chemistry 290 (18), 11601-11610, 2015 | 43 | 2015 |
| Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for Nicotinamide N-Methyltransferase D Chen, L Li, K Diaz, ID Iyamu, R Yadav, N Noinaj, R Huang Journal of medicinal chemistry 62 (23), 10783-10797, 2019 | 40 | 2019 |
| Non-histone arginine methylation by protein arginine methyltransferases AA Al-Hamashi, K Diaz, R Huang Current Protein and Peptide Science 21 (7), 699-712, 2020 | 31 | 2020 |
| Acetylation of lysine 92 improves the chaperone and anti-apoptotic activities of human αB-crystallin RB Nahomi, R Huang, SK Nandi, B Wang, S Padmanabha, ... Biochemistry 52 (45), 8126-8138, 2013 | 30 | 2013 |
| Discovery of bisubstrate inhibitors for protein N-terminal methyltransferase 1 D Chen, G Dong, N Noinaj, R Huang Journal of medicinal chemistry 62 (7), 3773-3779, 2019 | 26 | 2019 |
| Chemical Biology of Protein N‐Terminal Methyltransferases R Huang ChemBioChem 20 (8), 976-984, 2019 | 22 | 2019 |
| MassSQUIRM: An assay for quantitative measurement of lysine demethylase activity LP Blair, NL Avaritt, R Huang, PA Cole, SD Taverna, AJ Tackett Epigenetics 6 (4), 490-499, 2011 | 22 | 2011 |
| Probing the plasticity in the active site of protein N-terminal methyltransferase 1 using bisubstrate analogues D Chen, C Dong, G Dong, K Srinivasan, J Min, N Noinaj, R Huang Journal of medicinal chemistry 63 (15), 8419-8431, 2020 | 21 | 2020 |
| A direct, ratiometric, and quantitative MALDI–MS assay for protein methyltransferases and acetyltransferases SL Richardson, P Hanjra, G Zhang, BD Mackie, DL Peterson, R Huang Analytical biochemistry 478, 59-64, 2015 | 21 | 2015 |
| An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2 C Dong, G Dong, L Li, L Zhu, W Tempel, Y Liu, R Huang, J Min Communications Biology 1 (1), 183, 2018 | 20 | 2018 |
| Facile synthesis of SAM–peptide conjugates through alkyl linkers targeting protein N-terminal methyltransferase 1 G Zhang, R Huang RSC advances 6 (8), 6768-6771, 2016 | 20 | 2016 |
| Past, present, and perspectives of protein N-terminal methylation K Diaz, Y Meng, R Huang Current opinion in chemical biology 63, 115-122, 2021 | 18 | 2021 |
| Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5 AA Al-Hamashi, D Chen, Y Deng, G Dong, R Huang Acta Pharmaceutica Sinica B 11 (9), 2709-2718, 2021 | 15 | 2021 |
| Optimization of high-throughput methyltransferase assays for the discovery of small molecule inhibitors G Dong, A Yasgar, DL Peterson, A Zakharov, D Talley, KCC Cheng, ... ACS combinatorial science 22 (8), 422-432, 2020 | 15 | 2020 |
| Enhanced interrogation: emerging strategies for cell signaling inhibition R Huang, I Martinez-Ferrando, PA Cole Nature structural & molecular biology 17 (6), 646-649, 2010 | 15 | 2010 |
