Celeste M Karch
Celeste M Karch
Verified email at psychiatry.wustl.edu
TitleCited byYear
Alzheimer’s disease risk genes and mechanisms of disease pathogenesis
CM Karch, AM Goate
Biological psychiatry 77 (1), 43-51, 2015
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease
C Cruchaga, CM Karch, SC Jin, BA Benitez, Y Cai, R Guerreiro, O Harari, ...
Nature 505 (7484), 550, 2014
Alzheimer’s disease genetics: from the bench to the clinic
CM Karch, C Cruchaga, AM Goate
Neuron 83 (1), 11-26, 2014
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer’s disease
C Cruchaga, JSK Kauwe, O Harari, SC Jin, Y Cai, CM Karch, BA Benitez, ...
Neuron 78 (2), 256-268, 2013
Expression of novel Alzheimer’s disease risk genes in control and Alzheimer’s disease brains
CM Karch, AT Jeng, P Nowotny, J Cady, C Cruchaga, AM Goate
PloS one 7 (11), e50976, 2012
Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS
CM Karch, M Prudencio, DD Winkler, PJ Hart, DR Borchelt
Proceedings of the National Academy of Sciences 106 (19), 7774-7779, 2009
Coding variants in TREM2 increase risk for Alzheimer's disease
SC Jin, BA Benitez, CM Karch, B Cooper, T Skorupa, D Carrell, JB Norton, ...
Human molecular genetics 23 (21), 5838-5846, 2014
Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: αB-crystallin modulates aggregation
J Wang, G Xu, H Li, V Gonzales, D Fromholt, C Karch, NG Copeland, ...
Human molecular genetics 14 (16), 2335-2347, 2005
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
RS Desikan, CC Fan, Y Wang, AJ Schork, HJ Cabral, LA Cupples, ...
PLoS medicine 14 (3), e1002258, 2017
A limited role for disulfide cross-linking in the aggregation of mutant SOD1 linked to familial amyotrophic lateral sclerosis
CM Karch, DR Borchelt
Journal of Biological Chemistry 283 (20), 13528-13537, 2008
Extracellular tau levels are influenced by variability in tau that is associated with tauopathies
CM Karch, AT Jeng, AM Goate
Journal of Biological Chemistry, 2012
Immature copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis
SV Seetharaman, M Prudencio, C Karch, SP Holloway, DR Borchelt, ...
Experimental Biology and Medicine 234 (10), 1140-1154, 2009
Tau kinetics in neurons and the human central nervous system
C Sato, NR Barthélemy, KG Mawuenyega, BW Patterson, BA Gordon, ...
Neuron 97 (6), 1284-1298. e7, 2018
Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease
JSK Kauwe, C Cruchaga, CM Karch, B Sadler, M Lee, K Mayo, W Latu, ...
PloS one 6 (2), e15918, 2011
Association between genetic traits for immune-mediated diseases and Alzheimer disease
JS Yokoyama, Y Wang, AJ Schork, WK Thompson, CM Karch, ...
JAMA neurology 73 (6), 691-697, 2016
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
DL Kober, JM Alexander-Brett, CM Karch, C Cruchaga, M Colonna, ...
Elife 5, e20391, 2016
Genome-wide association study of CSF levels of 59 Alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation
JSK Kauwe, MH Bailey, PG Ridge, R Perry, ME Wadsworth, KL Hoyt, ...
PLoS genetics 10 (10), e1004758, 2014
The PSEN1, p. E318G variant increases the risk of Alzheimer's disease in APOE-ε4 carriers
BA Benitez, CM Karch, Y Cai, SC Jin, B Cooper, D Carrell, S Bertelsen, ...
PLoS genetics 9 (8), e1003685, 2013
An efficient platform for astrocyte differentiation from human induced pluripotent stem cells
TCW Julia, M Wang, AA Pimenova, KR Bowles, BJ Hartley, E Lacin, ...
Stem Cell Reports 9 (2), 600-614, 2017
Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases
R Ferrari, Y Wang, J Vandrovcova, S Guelfi, A Witeolar, CM Karch, ...
J Neurol Neurosurg Psychiatry 88 (2), 152-164, 2017
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