Celeste M Karch
Celeste M Karch
Verified email at psychiatry.wustl.edu
TitleCited byYear
Alzheimer’s disease risk genes and mechanisms of disease pathogenesis
CM Karch, AM Goate
Biological psychiatry 77 (1), 43-51, 2015
4162015
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease
C Cruchaga, CM Karch, SC Jin, BA Benitez, Y Cai, R Guerreiro, O Harari, ...
Nature 505 (7484), 550, 2014
3202014
Alzheimer’s disease genetics: from the bench to the clinic
CM Karch, C Cruchaga, AM Goate
Neuron 83 (1), 11-26, 2014
2602014
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer’s disease
C Cruchaga, JSK Kauwe, O Harari, SC Jin, Y Cai, CM Karch, BA Benitez, ...
Neuron 78 (2), 256-268, 2013
2152013
Expression of novel Alzheimer’s disease risk genes in control and Alzheimer’s disease brains
CM Karch, AT Jeng, P Nowotny, J Cady, C Cruchaga, AM Goate
PloS one 7 (11), e50976, 2012
1942012
Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS
CM Karch, M Prudencio, DD Winkler, PJ Hart, DR Borchelt
Proceedings of the National Academy of Sciences 106 (19), 7774-7779, 2009
1782009
Coding variants in TREM2 increase risk for Alzheimer's disease
SC Jin, BA Benitez, CM Karch, B Cooper, T Skorupa, D Carrell, JB Norton, ...
Human molecular genetics 23 (21), 5838-5846, 2014
1302014
Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: αB-crystallin modulates aggregation
J Wang, G Xu, H Li, V Gonzales, D Fromholt, C Karch, NG Copeland, ...
Human molecular genetics 14 (16), 2335-2347, 2005
1252005
A limited role for disulfide cross-linking in the aggregation of mutant SOD1 linked to familial amyotrophic lateral sclerosis
CM Karch, DR Borchelt
Journal of Biological Chemistry 283 (20), 13528-13537, 2008
1072008
Extracellular tau levels are influenced by variability in tau that is associated with tauopathies
CM Karch, AT Jeng, AM Goate
Journal of Biological Chemistry, 2012
982012
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
RS Desikan, CC Fan, Y Wang, AJ Schork, HJ Cabral, LA Cupples, ...
PLoS medicine 14 (3), e1002258, 2017
962017
Immature copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis
SV Seetharaman, M Prudencio, C Karch, SP Holloway, DR Borchelt, ...
Experimental Biology and Medicine 234 (10), 1140-1154, 2009
872009
Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease
JSK Kauwe, C Cruchaga, CM Karch, B Sadler, M Lee, K Mayo, W Latu, ...
PloS one 6 (2), e15918, 2011
772011
Tau kinetics in neurons and the human central nervous system
C Sato, NR Barthélemy, KG Mawuenyega, BW Patterson, BA Gordon, ...
Neuron 97 (6), 1284-1298. e7, 2018
672018
Association between genetic traits for immune-mediated diseases and Alzheimer disease
JS Yokoyama, Y Wang, AJ Schork, WK Thompson, CM Karch, ...
JAMA neurology 73 (6), 691-697, 2016
642016
Genome-wide association study of CSF levels of 59 Alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation
JSK Kauwe, MH Bailey, PG Ridge, R Perry, ME Wadsworth, KL Hoyt, ...
PLoS genetics 10 (10), e1004758, 2014
562014
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
DL Kober, JM Alexander-Brett, CM Karch, C Cruchaga, M Colonna, ...
Elife 5, e20391, 2016
542016
The PSEN1, p. E318G variant increases the risk of Alzheimer's disease in APOE-ε4 carriers
BA Benitez, CM Karch, Y Cai, SC Jin, B Cooper, D Carrell, S Bertelsen, ...
PLoS genetics 9 (8), e1003685, 2013
492013
An efficient platform for astrocyte differentiation from human induced pluripotent stem cells
TCW Julia, M Wang, AA Pimenova, KR Bowles, BJ Hartley, E Lacin, ...
Stem Cell Reports 9 (2), 600-614, 2017
412017
Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases
R Ferrari, Y Wang, J Vandrovcova, S Guelfi, A Witeolar, CM Karch, ...
J Neurol Neurosurg Psychiatry 88 (2), 152-164, 2017
382017
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