| Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions BA Stewart, HL Atwood, JJ Renger, J Wang, CF Wu Journal of Comparative Physiology A 175, 179-191, 1994 | 886 | 1994 |
| Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl … CD Cox, MJ Breslin, DB Whitman, JD Schreier, GB McGaughey, ... Journal of medicinal chemistry 53 (14), 5320-5332, 2010 | 420 | 2010 |
| Promotion of sleep by suvorexant—a novel dual orexin receptor antagonist CJ Winrow, AL Gotter, CD Cox, SM Doran, PL Tannenbaum, MJ Breslin, ... Journal of neurogenetics 25 (1-2), 52-61, 2011 | 298 | 2011 |
| A developmental switch in neurotransmitter flux enhances synaptic efficacy by affecting AMPA receptor activation JJ Renger, C Egles, G Liu Neuron 29 (2), 469-484, 2001 | 257 | 2001 |
| Internalized tau oligomers cause neurodegeneration by inducing accumulation of pathogenic tau in human neurons derived from induced pluripotent stem cells M Usenovic, S Niroomand, RE Drolet, L Yao, RC Gaspar, NG Hatcher, ... Journal of Neuroscience 35 (42), 14234-14250, 2015 | 239 | 2015 |
| Essential thalamic contribution to slow waves of natural sleep F David, JT Schmiedt, HL Taylor, G Orban, G Di Giovanni, VN Uebele, ... Journal of Neuroscience 33 (50), 19599-19610, 2013 | 236 | 2013 |
| Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of ITwindow FM Dreyfus, A Tscherter, AC Errington, JJ Renger, HS Shin, VN Uebele, ... Journal of Neuroscience 30 (1), 99-109, 2010 | 236 | 2010 |
| Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapses Z Huang, R Lujan, I Kadurin, VN Uebele, JJ Renger, AC Dolphin, ... Nature neuroscience 14 (4), 478-486, 2011 | 210 | 2011 |
| Presynaptic Cav3. 2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons MO Jacus, VN Uebele, JJ Renger, SM Todorovic Journal of Neuroscience 32 (27), 9374-9382, 2012 | 197 | 2012 |
| International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin receptor function, nomenclature and pharmacology AL Gotter, AL Webber, PJ Coleman, JJ Renger, CJ Winrow Pharmacological reviews 64 (3), 389-420, 2012 | 194 | 2012 |
| A sensitive aβ oligomer assay discriminates Alzheimer's and aged control cerebrospinal fluid MJ Savage, J Kalinina, A Wolfe, K Tugusheva, R Korn, T Cash-Mason, ... Journal of Neuroscience 34 (8), 2884-2897, 2014 | 186 | 2014 |
| Discovery and development of orexin receptor antagonists as therapeutics for insomnia CJ Winrow, JJ Renger British journal of pharmacology 171 (2), 283-293, 2014 | 167 | 2014 |
| Pharmacological characterization of MK-6096–a dual orexin receptor antagonist for insomnia CJ Winrow, AL Gotter, CD Cox, PL Tannenbaum, SL Garson, SM Doran, ... Neuropharmacology 62 (2), 978-987, 2012 | 160 | 2012 |
| Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors J Yin, K Babaoglu, CA Brautigam, L Clark, Z Shao, TH Scheuermann, ... Nature Structural & Molecular Biology 23 (4), 293-299, 2016 | 152 | 2016 |
| Design, Synthesis, and Evaluation of a Novel 4-Aminomethyl-4-fluoropiperidine as a T-Type Ca2+ Channel Antagonist WD Shipe, JC Barrow, ZQ Yang, CW Lindsley, FV Yang, KAS Schlegel, ... Journal of medicinal chemistry 51 (13), 3692-3695, 2008 | 143 | 2008 |
| Calcineurin signaling mediates activity-dependent relocation of the axon initial segment MD Evans, RP Sammons, S Lebron, AS Dumitrescu, TBK Watkins, ... Journal of Neuroscience 33 (16), 6950-6963, 2013 | 138 | 2013 |
| Discovery of [(2R,5R)‐5‐{[(5‐Fluoropyridin‐2‐yl)oxy]methyl}‐2‐methylpiperidin‐1‐yl][5‐methyl‐2‐(pyrimidin‐2‐yl)phenyl]methanone (MK‐6096): A Dual Orexin … PJ Coleman, JD Schreier, CD Cox, MJ Breslin, DB Whitman, MJ Bogusky, ... ChemMedChem 7 (3), 415-424, 2012 | 138 | 2012 |
| Discovery of a 3-(4-pyrimidinyl) indazole (MLi-2), an orally available and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor that reduces brain kinase activity JD Scott, DE DeMong, TJ Greshock, K Basu, X Dai, J Harris, A Hruza, ... Journal of medicinal chemistry 60 (7), 2983-2992, 2017 | 132 | 2017 |
| State-dependent properties of a new T-type calcium channel blocker enhance CaV3. 2 selectivity and support analgesic effects A Francois, N Kerckhove, M Meleine, A Alloui, C Barrere, A Gelot, ... Pain 154 (2), 283-293, 2013 | 132 | 2013 |
| Concomitant alterations of physiological and developmental plasticity in Drosophila CaM kinase II-inhibited synapses J Wang, JI Renger, LC Griffith, RJ Greenspan, CF Wu Neuron 13 (6), 1373-1384, 1994 | 132 | 1994 |
Christopher WinrowCyclerion TherapeuticsVerified email at cyclerion.com
