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Paul Dutchak
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Year
Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21
T Inagaki, P Dutchak, G Zhao, X Ding, L Gautron, V Parameswara, Y Li, ...
Cell metabolism 5 (6), 415-425, 2007
17122007
Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones
PA Dutchak, T Katafuchi, AL Bookout, JH Choi, TY Ruth, DJ Mangelsdorf, ...
Cell 148 (3), 556-567, 2012
6122012
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ
W Wei, PA Dutchak, X Wang, X Ding, X Wang, AL Bookout, R Goetz, ...
Proceedings of the National Academy of Sciences 109 (8), 3143-3148, 2012
4082012
Metabolic Networks Influencing Skeletal Muscle Fiber Composition
I Bourdeau-Julien, CF Sephton, PA Dutchak
Frontiers in Cell and Developmental Biology 6, 125, 2018
632018
Loss of a negative regulator of mTORC1 induces aerobic glycolysis and altered fiber composition in skeletal muscle
PA Dutchak, SJ Estill-Terpack, AA Plec, X Zhao, C Yang, J Chen, B Ko, ...
Cell reports 23 (7), 1907-1914, 2018
552018
Regulation of hematopoiesis and methionine homeostasis by mTORC1 inhibitor NPRL2
PA Dutchak, S Laxman, SJ Estill, C Wang, Y Wang, Y Wang, GB Bulut, ...
Cell reports 12 (3), 371-379, 2015
482015
FUS contributes to mTOR-dependent inhibition of translation
M Sévigny, IB Julien, JP Venkatasubramani, JB Hui, PA Dutchak, ...
Journal of Biological Chemistry 295 (52), 18459-18473, 2020
332020
Synaptic dysfunction in ALS and FTD: anatomical and molecular changes provide insights into mechanisms of disease
PA Gelon, PA Dutchak, CF Sephton
Frontiers in Molecular Neuroscience, 510, 2022
252022
NPRL2 inhibition of mTORC1 controls sodium channel expression and brain amino acid homeostasis
JB Hui, JCH Silva, MC Pelaez, M Sévigny, JP Venkatasubramani, ...
Eneuro 9 (2), 2022
62022
A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics
G Nicolas, M Sévigny, F Lecoquierre, F Marguet, A Deschênes, ...
Acta neuropathologica communications 10 (1), 20, 2022
62022
Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation
G Aggarwal, S Banerjee, SA Jones, Y Benchaar, J Bélanger, M Sévigny, ...
Journal of Biological Chemistry 299 (12), 2023
22023
GATOR1 Mutations Impair PI3 Kinase-Dependent Growth Factor Signaling Regulation of mTORC1
M Muller, J Bélanger, I Hadj-Aissa, C Zhang, CF Sephton, PA Dutchak
Int. J. Mol. Sci. 25 (4), doi.org/10.3390/ijms25042068, 2024
2024
Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by NF-κB inhibition
CFS Mari Carmen Pelaez, Antoine Desmeules, Pauline A. Gelon, Bastien Glasson ...
Acta Neuropathologica Communications 11, 1-21, 2023
2023
Antisense oligonucleotides targeting miR‐29b binding site increase translation of progranulin protein: potential therapeutic strategy for progranulin‐deficient frontotemporal …
G Aggarwal, S Banerjee, SA Jones, M Pavlack, Y Benchaar, J Bélanger, ...
Alzheimer's & Dementia 18, e067828, 2022
2022
Altering cellular differentiation and energy metabolism by the mTORC1 inhibitor NPRL2
PA Dutchak, SJ Terpack, BP Tu
Molecular Cancer Research 14 (4_Supplement), B08-B08, 2016
2016
Metabolic Regulation by Fibroblast Growth Factor 21
PA Dutchak
2011
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