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| How to improve docking accuracy of AutoDock4. 2: a case study using different electrostatic potentials X Hou, J Du, J Zhang, L Du, H Fang, M Li Journal of Chemical Information and Modeling 53 (1), 188-200, 2013 | 109 | 2013 |
| New techniques and strategies in drug discovery J Du, J Guo, D Kang, Z Li, G Wang, J Wu, Z Zhang, H Fang, X Hou, ... Chinese Chemical Letters 31 (7), 1695-1708, 2020 | 92 | 2020 |
| Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation X Hou, D Rooklin, H Fang, Y Zhang Scientific Reports 6 (1), 38186, 2016 | 90 | 2016 |
| Incorporating explicit water molecules and ligand conformation stability in machine-learning scoring functions J Lu, X Hou, C Wang, Y Zhang Journal of chemical information and modeling 59 (11), 4540-4549, 2019 | 78 | 2019 |
| Design, synthesis and preliminary bioactivity studies of 1, 3, 4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors P Guan, X Hou, F Wang, F Yi, W Xu, H Fang Bioorganic & medicinal chemistry 20 (12), 3865-3872, 2012 | 65 | 2012 |
| Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site C Pan, HD Liu, Z Gong, X Yu, XB Hou, DD Xie, XB Zhu, HW Li, JY Tang, ... Scientific reports 3 (1), 2333, 2013 | 64 | 2013 |
| Selective and noncovalent targeting of RAS mutants for inhibition and degradation KW Teng, ST Tsai, T Hattori, C Fedele, A Koide, C Yang, X Hou, Y Zhang, ... Nature communications 12 (1), 2656, 2021 | 53 | 2021 |
| Improved antiproliferative activity of 1, 3, 4-thiadiazole-containing histone deacetylase (HDAC) inhibitors by introduction of the heteroaromatic surface recognition motif P Guan, L Wang, X Hou, Y Wan, W Xu, W Tang, H Fang Bioorganic & medicinal chemistry 22 (21), 5766-5775, 2014 | 50 | 2014 |
| Design, synthesis and biological evaluation of quinoline derivatives as HDAC class I inhibitors C Chen, X Hou, G Wang, W Pan, X Yang, Y Zhang, H Fang European journal of medicinal chemistry 133, 11-23, 2017 | 47 | 2017 |
| Enhancing the sensitivity of pharmacophore-based virtual screening by incorporating customized ZBG features: a case study using histone deacetylase 8 X Hou, J Du, R Liu, Y Zhou, M Li, W Xu, H Fang Journal of chemical information and modeling 55 (4), 861-871, 2015 | 47 | 2015 |
| Design, synthesis and preliminary bioactivity evaluations of substituted quinoline hydroxamic acid derivatives as novel histone deacetylase (HDAC) inhibitors L Wang, X Hou, H Fu, X Pan, W Xu, W Tang, H Fang Bioorganic & Medicinal Chemistry 23 (15), 4364-4374, 2015 | 40 | 2015 |
| Discovery of peptide boronate derivatives as histone deacetylase and proteasome dual inhibitors for overcoming bortezomib resistance of multiple myeloma Y Zhou, X Liu, J Xue, L Liu, T Liang, W Li, X Yang, X Hou, H Fang Journal of Medicinal Chemistry 63 (9), 4701-4715, 2020 | 38 | 2020 |
| Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors Y Wan, S Wu, G Xiao, T Liu, X Hou, C Chen, P Guan, X Yang, H Fang Bioorganic & medicinal chemistry 23 (9), 1994-2003, 2015 | 33 | 2015 |
| Protein flexibility in docking-based virtual screening: discovery of novel lymphoid-specific tyrosine phosphatase inhibitors using multiple crystal structures X Hou, K Li, X Yu, J Sun, H Fang Journal of chemical information and modeling 55 (9), 1973-1983, 2015 | 31 | 2015 |
| Strategies to overcome drug resistance using SHP2 inhibitors M Liu, S Gao, RM Elhassan, X Hou, H Fang Acta Pharmaceutica Sinica B 11 (12), 3908-3924, 2021 | 28 | 2021 |
| Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors Y Wan, J Wang, M Chen, X Hou, H Fang Bioorganic & medicinal chemistry 23 (24), 7685-7693, 2015 | 27 | 2015 |
| Design, synthesis and preliminary bioactivity studies of imidazolidine-2, 4-dione derivatives as Bcl-2 inhibitors G Wang, Y Wang, L Wang, L Han, X Hou, H Fu, H Fang Bioorganic & medicinal chemistry 23 (23), 7359-7365, 2015 | 26 | 2015 |
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