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Christopher R Faehnle
Christopher R Faehnle
Pfizer La Jolla
Verified email at pfizer.com
Title
Cited by
Cited by
Year
The making of a slicer: activation of human Argonaute-1
CR Faehnle, E Elkayam, AD Haase, GJ Hannon, L Joshua-Tor
Cell reports 3 (6), 1901-1909, 2013
1682013
Mechanism of Dis3l2 substrate recognition in the Lin28–let-7 pathway
CR Faehnle, J Walleshauser, L Joshua-Tor
Nature 514 (7521), 252-256, 2014
1422014
Argonautes confront new small RNAs
CR Faehnle, L Joshua-Tor
Current opinion in chemical biology 11 (5), 569-577, 2007
1252007
PTEN functions by recruitment to cytoplasmic vesicles
A Naguib, G Bencze, H Cho, W Zheng, A Tocilj, E Elkayam, CR Faehnle, ...
Molecular cell 58 (2), 255-268, 2015
1052015
Multivalent recruitment of human argonaute by GW182
E Elkayam, CR Faehnle, M Morales, J Sun, H Li, L Joshua-Tor
Molecular cell 67 (4), 646-658. e3, 2017
1022017
Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis
CR Faehnle, J Walleshauser, L Joshua-Tor
Nature structural & molecular biology 24 (8), 658-665, 2017
532017
Examination of key intermediates in the catalytic cycle of aspartate-β-semialdehyde dehydrogenase from a Gram-positive infectious bacteria
CR Faehnle, J Le Coq, X Liu, RE Viola
Journal of Biological Chemistry 281 (41), 31031-31040, 2006
522006
A new branch in the family: structure of aspartate-β-semialdehyde dehydrogenase from Methanococcus jannaschii
CR Faehnle, JF Ohren, RE Viola
Journal of molecular biology 353 (5), 1055-1068, 2005
472005
Purification and preliminary characterization of brain aspartoacylase
RA Moore, J Le Coq, CR Faehnle, RE Viola
Archives of biochemistry and biophysics 413 (1), 1-8, 2003
422003
The initial step in the archaeal aspartate biosynthetic pathway catalyzed by a monofunctional aspartokinase
CR Faehnle, X Liu, A Pavlovsky, RE Viola
Acta Crystallographica Section F: Structural Biology and Crystallization …, 2006
362006
The catalytic machinery of a key enzyme in amino Acid biosynthesis
RE Viola, CR Faehnle, J Blanco, RA Moore, X Liu, BT Arachea, ...
Journal of amino acids 2011, 2011
352011
A rapid method for the purification of methanol dehydrogenase from Methylobacterium extorquens
Q Liu, JR Kirchhoff, CR Faehnle, RE Viola, RA Hudson
Protein expression and purification 46 (2), 316-320, 2006
352006
Critical catalytic functional groups in the mechanism of aspartate-β-semialdehyde dehydrogenase
J Blanco, RA Moore, CR Faehnle, RE Viola
Acta Crystallographica Section D: Biological Crystallography 60 (10), 1808-1815, 2004
302004
Structural characterization of inhibitors with selectivity against members of a homologous enzyme family
AG Pavlovsky, X Liu, CR Faehnle, N Potente, RE Viola
Chemical biology & drug design 79 (1), 128-136, 2012
292012
Argonaute MID domain takes centre stage
CR Faehnle, L Joshua‐Tor
EMBO reports 11 (8), 564-565, 2010
272010
The role of substrate-binding groups in the mechanism of aspartate-β-semialdehyde dehydrogenase
J Blanco, RA Moore, CR Faehnle, DM Coe, RE Viola
Acta Crystallographica Section D: Biological Crystallography 60 (8), 1388-1395, 2004
272004
Structural basis for discrimination between oxyanion substrates or inhibitors in aspartate-β-semialdehyde dehydrogenase
CR Faehnle, J Blanco, RE Viola
Acta Crystallographica Section D: Biological Crystallography 60 (12), 2320-2324, 2004
26*2004
The structure of a redundant enzyme: a second isoform of aspartate β-semialdehyde dehydrogenase in Vibrio cholerae
RE Viola, X Liu, JF Ohren, CR Faehnle
Acta Crystallographica Section D: Biological Crystallography 64 (3), 321-330, 2008
242008
Abstract LB-063: PTEN function is controlled by recruitment to cytoplasmic vesicles
A Naguib, G Bencze, H Cho, W Zheng, A Tocilj, E Elkayam, CR Faehnle, ...
Cancer Research 75 (15_Supplement), LB-063-LB-063, 2015
2015
Upstream activation of PTEN.
A Naguib, G Bencze, CR Faehnle, T Schalch, Z Lazar, CI Ruse, ...
Cancer Research 73 (8_Supplement), 5156-5156, 2013
2013
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