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Robert Harkness
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Stabilization of i-motif structures by 2′-β-fluorination of DNA
HA Assi, RW Harkness, N Martin-Pintado, CJ Wilds, R Campos-Olivas, ...
Nucleic Acids Research 44 (11), 4998-5009, 2016
652016
G-quadruplex dynamics.
RW Harkness, AK Mittermaier
Biochimica et Biophysica acta. Proteins and Proteomics 1865 (11 Pt B), 1544-1554, 2017
552017
G-register exchange dynamics in guanine quadruplexes
RW Harkness, AK Mittermaier
Nucleic Acids Research 44 (8), 3481-3494, 2016
392016
Oligomeric assembly regulating mitochondrial HtrA2 function as examined by methyl-TROSY NMR
Y Toyama, RW Harkness, TYT Lee, JT Maynes, LE Kay
Proceedings of the National Academy of Sciences 118 (11), e2025022118, 2021
322021
Mapping the energy landscapes of supramolecular assembly by thermal hysteresis
RW Harkness, N Avakyan, HF Sleiman, AK Mittermaier
Nature communications 9 (1), 3152, 2018
302018
Conformational dynamics of strand register shifts in DNA G-quadruplexes
JT Grün, C Hennecker, DP Klötzner, RW Harkness, I Bessi, A Heckel, ...
Journal of the American Chemical Society 142 (1), 264-273, 2019
242019
Rapid characterization of folding and binding interactions with thermolabile ligands by DSC
RW Harkness, S Slavkovic, PE Johnson, AK Mittermaier
Chemical communications 52 (92), 13471-13474, 2016
182016
Competing stress-dependent oligomerization pathways regulate self-assembly of the periplasmic protease-chaperone DegP
RW Harkness, Y Toyama, ZA Ripstein, H Zhao, AIM Sever, Q Luan, ...
Proceedings of the National Academy of Sciences 118 (32), e2109732118, 2021
132021
Dissecting the role of interprotomer cooperativity in the activation of oligomeric high-temperature requirement A2 protein
Y Toyama, RW Harkness, LE Kay
Proceedings of the National Academy of Sciences 118 (35), e2111257118, 2021
122021
Parallel reaction pathways accelerate folding of a guanine quadruplex
RW Harkness, C Hennecker, JT Grün, A Blümler, A Heckel, H Schwalbe, ...
Nucleic acids research 49 (3), 1247-1262, 2021
122021
Correlating histone acetylation with nucleosome core particle dynamics and function
TH Kim, ML Nosella, N Bolik-Coulon, RW Harkness, SK Huang, LE Kay
Proceedings of the National Academy of Sciences 120 (15), e2301063120, 2023
112023
Less is more: A simple methyl-TROSY based pulse scheme offers improved sensitivity in applications to high molecular weight complexes
N Bolik-Coulon, AIM Sever, RW Harkness, JM Aramini, Y Toyama, ...
Journal of Magnetic Resonance 346, 107326, 2023
82023
Structural basis of protein substrate processing by human mitochondrial high-temperature requirement A2 protease
Y Toyama, RW Harkness, LE Kay
Proceedings of the National Academy of Sciences 119 (17), e2203172119, 2022
72022
Global multi-method analysis of interaction parameters for reversibly self-associating macromolecules at high concentrations
A Parupudi, SK Chaturvedi, R Adão, RW Harkness, S Dragulin-Otto, ...
Scientific Reports 11 (1), 5741, 2021
62021
Analyzing multi-step ligand binding reactions for oligomeric proteins by NMR: Theoretical and computational considerations
RW Harkness, Y Toyama, LE Kay
Journal of Magnetic Resonance 318, 106802, 2020
62020
Experimental and computational determination of Brønsted coefficients for equilibrium transfer of the O,O‐dimethyl phosphorothioyl group between oxyanion …
DR Edwards, CI Maxwell, RW Harkness, AA Neverov, NJ Mosey, ...
Journal of Physical Organic Chemistry 25 (3), 258-266, 2012
52012
Flexible client-dependent cages in the assembly landscape of the periplasmic protease-chaperone DegP
RW Harkness, ZA Ripstein, JM Di Trani, LE Kay
Journal of the American Chemical Society 145 (24), 13015-13026, 2023
32023
Poly (ADP-ribosyl) ation enhances nucleosome dynamics and organizes DNA damage repair components within biomolecular condensates
ML Nosella, TH Kim, SK Huang, RW Harkness, M Goncalves, A Pan, ...
Molecular Cell 84 (3), 429-446. e17, 2024
22024
Measuring Biomolecular DSC Profiles with Thermolabile Ligands to Rapidly Characterize Folding and Binding Interactions
RW Harkness, PE Johnson, AK Mittermaier
JoVE (Journal of Visualized Experiments), e55959, 2017
22017
Activation of caspase-9 on the apoptosome as studied by methyl-TROSY NMR
AIM Sever, TR Alderson, E Rennella, JM Aramini, ZH Liu, RW Harkness, ...
Proceedings of the National Academy of Sciences 120 (51), e2310944120, 2023
12023
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Articles 1–20