Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis K Yamaguchi, L Yang, S McCall, J Huang, XX Yu, SK Pandey, S Bhanot, ... Hepatology 45 (6), 1366-1374, 2007 | 1187 | 2007 |
NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis R Bataller, RF Schwabe, YH Choi, L Yang, YH Paik, J Lindquist, T Qian, ... The Journal of clinical investigation 112 (9), 1383-1394, 2003 | 742 | 2003 |
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans A Omenetti, A Porrello, Y Jung, L Yang, Y Popov, SS Choi, RP Witek, ... The Journal of clinical investigation 118 (10), 3331-3342, 2008 | 441 | 2008 |
A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations ST Magness, R Bataller, L Yang, DA Brenner Hepatology 40 (5), 1151-1159, 2004 | 299 | 2004 |
Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease WK Syn, Y Jung, A Omenetti, M Abdelmalek, CD Guy, L Yang, J Wang, ... Gastroenterology 137 (4), 1478-1488. e8, 2009 | 284 | 2009 |
Vascular endothelial growth factor promotes fibrosis resolution and repair in mice L Yang, J Kwon, Y Popov, GB Gajdos, T Ordog, RA Brekken, ... Gastroenterology 146 (5), 1339-1350. e1, 2014 | 279 | 2014 |
Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers L Yang, Y Jung, A Omenetti, RP Witek, S Choi, HM Vandongen, J Huang, ... Stem cells 26 (8), 2104-2113, 2008 | 270 | 2008 |
Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis SS Choi, A Omenetti, RP Witek, CA Moylan, WK Syn, Y Jung, L Yang, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 297 (6 …, 2009 | 264 | 2009 |
Smoothened is a master regulator of adult liver repair GA Michelotti, G Xie, M Swiderska, SS Choi, G Karaca, L Krüger, ... The Journal of clinical investigation 123 (6), 2380-2394, 2013 | 248 | 2013 |
Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells L Yang, Y Wang, H Mao, S Fleig, A Omenetti, KD Brown, JK Sicklick, YX Li, ... Journal of hepatology 48 (1), 98-106, 2008 | 234 | 2008 |
Hedgehog-mediated mesenchymal–epithelial interactions modulate hepatic response to bile duct ligation A Omenetti, L Yang, YX Li, SJ McCall, Y Jung, JK Sicklick, J Huang, ... Laboratory investigation 87 (5), 499-514, 2007 | 233 | 2007 |
Liver cell–derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells RP Witek, L Yang, R Liu, Y Jung, A Omenetti, WK Syn, SS Choi, ... Gastroenterology 136 (1), 320-330. e2, 2009 | 232 | 2009 |
Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct–ligated rats R Bataller, E Gäbele, CJ Parsons, T Morris, L Yang, R Schoonhoven, ... Hepatology 41 (5), 1046-1055, 2005 | 223 | 2005 |
PPARγ agonists prevent TGFβ1/Smad3-signaling in human hepatic stellate cells C Zhao, W Chen, L Yang, L Chen, SA Stimpson, AM Diehl Biochemical and biophysical research communications 350 (2), 385-391, 2006 | 196 | 2006 |
DNase I–hypersensitive sites enhance α1 (I) collagen gene expression in hepatic stellate cells Y Yata, A Scanga, A Gillan, L Yang, S Reif, M Breindl, DA Brenner, ... Hepatology 37 (2), 267-276, 2003 | 194 | 2003 |
Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans Y Jung, KD Brown, RP Witek, A Omenetti, L Yang, M Vandongen, ... Gastroenterology 134 (5), 1532-1543. e3, 2008 | 190 | 2008 |
Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver R Bataller, E Gabele, R Schoonhoven, T Morris, M Lehnert, L Yang, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 285 (3 …, 2003 | 186 | 2003 |
Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces DA Simonetto, H Yang, M Yin, TM de Assuncao, JH Kwon, M Hilscher, ... Hepatology 61 (2), 648-659, 2015 | 176 | 2015 |
Regulation of peroxisome proliferator-activated receptor-γ in liver fibrosis L Yang, CC Chan, OS Kwon, S Liu, J McGhee, SA Stimpson, LZ Chen, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 291 (5 …, 2006 | 157 | 2006 |
Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice L Yang, R Bataller, J Dulyx, TM Coffman, P Ginès, RA Rippe, DA Brenner Journal of hepatology 43 (2), 317-323, 2005 | 153 | 2005 |