Lukasz Joachimiak
Lukasz Joachimiak
Verified email at - Homepage
Cited by
Cited by
Computational redesign of protein-protein interaction specificity
T Kortemme, LA Joachimiak, AN Bullock, AD Schuler, BL Stoddard, ...
Nature structural & molecular biology 11 (4), 371-379, 2004
The molecular architecture of the eukaryotic chaperonin TRiC/CCT
A Leitner, LA Joachimiak, A Bracher, L Mönkemeyer, T Walzthoeni, ...
Structure 20 (5), 814-825, 2012
The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation
S Tam, C Spiess, W Auyeung, L Joachimiak, B Chen, MA Poirier, ...
Nature structural & molecular biology 16 (12), 1279-1285, 2009
Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes
A Leitner, LA Joachimiak, P Unverdorben, T Walzthoeni, J Frydman, ...
Proceedings of the National Academy of Sciences 111 (26), 9455-9460, 2014
Inert and seed-competent tau monomers suggest structural origins of aggregation
H Mirbaha, D Chen, OA Morazova, KM Ruff, AM Sharma, X Liu, ...
Elife 7, e36584, 2018
A de novo protein binding pair by computational design and directed evolution
J Karanicolas, JE Corn, I Chen, LA Joachimiak, O Dym, SH Peck, ...
Molecular cell 42 (2), 250-260, 2011
Computational design of a new hydrogen bond network and at least a 300-fold specificity switch at a protein− protein interface
LA Joachimiak, T Kortemme, BL Stoddard, D Baker
Journal of molecular biology 361 (1), 195-208, 2006
The structural basis of substrate recognition by the eukaryotic chaperonin TRiC/CCT
LA Joachimiak, T Walzthoeni, CW Liu, R Aebersold, J Frydman
Cell 159 (5), 1042-1055, 2014
Tau local structure shields an amyloid-forming motif and controls aggregation propensity
D Chen, KW Drombosky, Z Hou, L Sari, OM Kashmer, BD Ryder, ...
Nature communications 10 (1), 2493, 2019
xTract: software for characterizing conformational changes of protein complexes by quantitative cross-linking mass spectrometry
T Walzthoeni, LA Joachimiak, G Rosenberger, HL Röst, L Malmström, ...
Nature methods 12 (12), 1185-1190, 2015
A gradient of ATP affinities generates an asymmetric power stroke driving the chaperonin TRIC/CCT folding cycle
S Reissmann, LA Joachimiak, B Chen, AS Meyer, A Nguyen, J Frydman
Cell reports 2 (4), 866-877, 2012
The chaperonin TRiC/CCT associates with prefoldin through a conserved electrostatic interface essential for cellular proteostasis
D Gestaut, SH Roh, B Ma, G Pintilie, LA Joachimiak, A Leitner, ...
Cell 177 (3), 751-765. e15, 2019
Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes
EM Sontag, LA Joachimiak, Z Tan, A Tomlinson, DE Housman, CG Glabe, ...
Proceedings of the National Academy of Sciences 110 (8), 3077-3082, 2013
Tau strains shape disease
J Vaquer-Alicea, MI Diamond, LA Joachimiak
Acta neuropathologica 142, 57-71, 2021
Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure
J Zhang, B Ma, F DiMaio, NR Douglas, LA Joachimiak, D Baker, ...
Structure 19 (5), 633-639, 2011
Structure and dynamics of the huntingtin exon-1 N-terminus: a solution NMR perspective
M Baias, PES Smith, K Shen, LA Joachimiak, S Zerko, W Kozminski, ...
Journal of the American Chemical Society 139 (3), 1168-1176, 2017
The ATP-powered gymnastics of TRiC/CCT: an asymmetric protein folding machine with a symmetric origin story
D Gestaut, A Limatola, L Joachimiak, J Frydman
Current opinion in structural biology 55, 50-58, 2019
Experimental and computational analyses of the energetic basis for dual recognition of immunity proteins by colicin endonucleases
AH Keeble, LA Joachimiak, MJ Maté, N Meenan, N Kirkpatrick, D Baker, ...
Journal of molecular biology 379 (4), 745-759, 2008
DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation
Z Hou, PM Wydorski, VA Perez, A Mendoza-Oliva, BD Ryder, H Mirbaha, ...
Nature communications 12 (1), 5338, 2021
Conservation of a novel protein associated with an antibiotic efflux operon in Burkholderia cenocepacia
BM Nair, LA Joachimiak, S Chattopadhyay, I Montano, JL Burns
FEMS microbiology letters 245 (2), 337-344, 2005
The system can't perform the operation now. Try again later.
Articles 1–20