| Critically ill patients with 2009 influenza A (H1N1) infection in Canada A Kumar, R Zarychanski, R Pinto, DJ Cook, J Marshall, J Lacroix, T Stelfox, ... Jama 302 (17), 1872-1879, 2009 | 1716 | 2009 |
| Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis M Briel, M Meade, A Mercat, RG Brower, D Talmor, SD Walter, AS Slutsky, ... Jama 303 (9), 865-873, 2010 | 1469 | 2010 |
| Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research AIR Maas, DK Menon, PD Adelson, N Andelic, MJ Bell, A Belli, P Bragge, ... The Lancet Neurology 16 (12), 987-1048, 2017 | 959 | 2017 |
| High-frequency oscillation in early acute respiratory distress syndrome ND Ferguson, DJ Cook, GH Guyatt, S Mehta, L Hand, P Austin, Q Zhou, ... New England Journal of Medicine 368 (9), 795-805, 2013 | 858 | 2013 |
| Failure to engage hospitalized elderly patients and their families in advance care planning DK Heyland, D Barwich, D Pichora, P Dodek, F Lamontagne, JJ You, ... JAMA internal medicine 173 (9), 778-787, 2013 | 460 | 2013 |
| Clinical presentation of patients with Ebola virus disease in Conakry, Guinea EI Bah, MC Lamah, T Fletcher, ST Jacob, DM Brett-Major, AA Sall, ... New England Journal of Medicine 372 (1), 40-47, 2015 | 434 | 2015 |
| Impact of emergency colectomy on survival of patients with fulminant Clostridium difficile colitis during an epidemic caused by a hypervirulent strain F Lamontagne, AC Labbé, O Haeck, O Lesur, M Lalancette, C Patino, ... Annals of surgery 245 (2), 267, 2007 | 416 | 2007 |
| Drug treatments for covid-19: living systematic review and network meta-analysis RAC Siemieniuk, JJ Bartoszko, L Ge, D Zeraatkar, A Izcovich, E Kum, ... Bmj 370, 2020 | 394 | 2020 |
| Interleukin-6 receptor antagonists in critically ill patients with Covid-19. AC Gordon, PR Mouncey, F Al-Beidh, KM Rowan, AD Nichol, YM Arabi, ... The New England journal of medicine, 2021 | 380 | 2021 |
| Effect of hydrocortisone on mortality and organ support in patients with severe COVID-19: the REMAP-CAP COVID-19 corticosteroid domain randomized clinical trial DC Angus, L Derde, F Al-Beidh, D Annane, Y Arabi, A Beane, ... Jama 324 (13), 1317-1329, 2020 | 365 | 2020 |
| Barriers to goals of care discussions with seriously ill hospitalized patients and their families: a multicenter survey of clinicians JJ You, J Downar, RA Fowler, F Lamontagne, IWY Ma, D Jayaraman, ... JAMA internal medicine 175 (4), 549-556, 2015 | 293 | 2015 |
| One-year outcomes in caregivers of critically ill patients JI Cameron, LM Chu, A Matte, G Tomlinson, L Chan, C Thomas, ... New England Journal of Medicine 374 (19), 1831-1841, 2016 | 277 | 2016 |
| Caring for critically ill patients with Ebola virus disease. Perspectives from West Africa RA Fowler, T Fletcher, WA Fischer, F Lamontagne, S Jacob, D Brett-Major, ... American journal of respiratory and critical care medicine 190 (7), 733-737, 2014 | 259 | 2014 |
| Prevalence, characteristics, and publication of discontinued randomized trials B Kasenda, E Von Elm, J You, A Blümle, Y Tomonaga, R Saccilotto, ... Jama 311 (10), 1045-1052, 2014 | 251 | 2014 |
| Potential impact on estimated treatment effects of information lost to follow-up in randomised controlled trials (LOST-IT): systematic review EA Akl, M Briel, JJ You, X Sun, BC Johnston, JW Busse, S Mulla, ... Bmj 344, 2012 | 247 | 2012 |
| The RECOVER program: disability risk groups and 1-year outcome after 7 or more days of mechanical ventilation MS Herridge, LM Chu, A Matte, G Tomlinson, L Chan, C Thomas, ... American journal of respiratory and critical care medicine 194 (7), 831-844, 2016 | 232 | 2016 |
| Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury R Wald, NKJ Adhikari, OM Smith, MA Weir, K Pope, A Cohen, K Thorpe, ... Kidney international 88 (4), 897-904, 2015 | 197 | 2015 |
| Thrombocytopenia in critically ill patients receiving thromboprophylaxis: frequency, risk factors, and outcomes DR Williamson, M Albert, D Heels-Ansdell, DM Arnold, F Lauzier, ... Chest 144 (4), 1207-1215, 2013 | 157 | 2013 |
| Rationale and design of the left atrial appendage occlusion study (LAAOS) III R Whitlock, J Healey, J Vincent, K Brady, K Teoh, A Royse, P Shah, Y Guo, ... Annals of cardiothoracic surgery 3 (1), 45, 2014 | 149 | 2014 |
| Inconsistent definitions for intention-to-treat in relation to missing outcome data: systematic review of the methods literature M Alshurafa, M Briel, EA Akl, T Haines, P Moayyedi, SJ Gentles, L Rios, ... PLoS One 7 (11), e49163, 2012 | 143 | 2012 |
