| Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021 | 13164* | 2021 |
| Potential therapeutic applications of autophagy DC Rubinsztein, JE Gestwicki, LO Murphy, DJ Klionsky Nature reviews Drug discovery 6 (4), 304-312, 2007 | 1245 | 2007 |
| Synthetic multivalent ligands as probes of signal transduction LL Kiessling, JE Gestwicki, LE Strong Angewandte Chemie International Edition 45 (15), 2348-2368, 2006 | 1009 | 2006 |
| Influencing receptor− ligand binding mechanisms with multivalent ligand architecture JE Gestwicki, CW Cairo, LE Strong, KA Oetjen, LL Kiessling Journal of the American Chemical Society 124 (50), 14922-14933, 2002 | 909 | 2002 |
| Synthetic multivalent ligands in the exploration of cell-surface interactions LL Kiessling, JE Gestwicki, LE Strong Current opinion in chemical biology 4 (6), 696-703, 2000 | 750 | 2000 |
| Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate EB Bertelsen, L Chang, JE Gestwicki, ERP Zuiderweg Proceedings of the National Academy of Sciences 106 (21), 8471-8476, 2009 | 566 | 2009 |
| Heat shock protein 70 (hsp70) as an emerging drug target CG Evans, L Chang, JE Gestwicki Journal of medicinal chemistry 53 (12), 4585-4602, 2010 | 498 | 2010 |
| Heat shock proteins 70 and 90 inhibit early stages of amyloid β-(1–42) aggregation in vitro CG Evans, S Wisén, JE Gestwicki Journal of Biological Chemistry 281 (44), 33182-33191, 2006 | 485 | 2006 |
| Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits SW Min, X Chen, TE Tracy, Y Li, Y Zhou, C Wang, K Shirakawa, ... Nature medicine 21 (10), 1154-1162, 2015 | 479 | 2015 |
| Control of multivalent interactions by binding epitope density CW Cairo, JE Gestwicki, M Kanai, LL Kiessling Journal of the American Chemical Society 124 (8), 1615-1619, 2002 | 471 | 2002 |
| Structure–activity Relationships of amyloid beta‐aggregation inhibitors based on curcumin: influence of linker length and flexibility AA Reinke, JE Gestwicki Chemical biology & drug design 70 (3), 206-215, 2007 | 394 | 2007 |
| A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis CP Chang, JR Neilson, JH Bayle, JE Gestwicki, A Kuo, K Stankunas, ... Cell 118 (5), 649-663, 2004 | 373 | 2004 |
| Inter-receptor communication through arrays of bacterial chemoreceptors JE Gestwicki, LL Kiessling Nature 415 (6867), 81-84, 2002 | 330 | 2002 |
| Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo EE Congdon, JW Wu, N Myeku, YH Figueroa, M Herman, PS Marinec, ... Autophagy 8 (4), 609-622, 2012 | 322 | 2012 |
| Features of protein–protein interactions that translate into potent inhibitors: topology, surface area and affinity MC Smith, JE Gestwicki Expert reviews in molecular medicine 14, e16, 2012 | 303 | 2012 |
| Chemical manipulation of hsp70 ATPase activity regulates tau stability UK Jinwal, Y Miyata, J Koren, JR Jones, JH Trotter, L Chang, J O'Leary, ... Journal of neuroscience 29 (39), 12079-12088, 2009 | 272 | 2009 |
| Defining Hsp70 subnetworks in dengue virus replication reveals key vulnerability in flavivirus infection S Taguwa, K Maringer, X Li, D Bernal-Rubio, JN Rauch, JE Gestwicki, ... Cell 163 (5), 1108-1123, 2015 | 262 | 2015 |
| Harnessing chaperones to generate small-molecule inhibitors of amyloid ß aggregation JE Gestwicki, GR Crabtree, IA Graef Science 306 (5697), 865-869, 2004 | 245 | 2004 |
| Pharmacological chaperone for α-crystallin partially restores transparency in cataract models LN Makley, KA McMenimen, BT DeVree, JW Goldman, BN McGlasson, ... Science 350 (6261), 674-677, 2015 | 244 | 2015 |
| Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity JH Bayle, JS Grimley, K Stankunas, JE Gestwicki, TJ Wandless, ... Chemistry & biology 13 (1), 99-107, 2006 | 243 | 2006 |
Laura L. KiesslingMassachusetts Institute of TechnologyVerified email at mit.edu
