Jimmy Dikeakos
Jimmy Dikeakos
Associate Professor
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Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53
P Di Lello, LMM Jenkins, TN Jones, BD Nguyen, T Hara, H Yamaguchi, ...
Molecular cell 22 (6), 731-740, 2006
Sending proteins to dense core secretory granules: still a lot to sort out
JD Dikeakos, TL Reudelhuber
The Journal of cell biology 177 (2), 191-196, 2007
Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy
I Ullah, J Prévost, MS Ladinsky, H Stone, M Lu, SP Anand, ...
Immunity 54 (9), 2143-2158. e15, 2021
Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2
R Gasser, M Cloutier, J Prévost, C Fink, É Ducas, S Ding, N Dussault, ...
Cell reports 34 (9), 108790, 2021
Small Molecule Inhibition of HIV-1–Induced MHC-I Down-Regulation Identifies a Temporally Regulated Switch in Nef Action
JD Dikeakos, KM Atkins, L Thomas, L Emert-Sedlak, IJL Byeon, J Jung, ...
Molecular biology of the cell 21 (19), 3279-3292, 2010
An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I
JD Dikeakos, L Thomas, G Kwon, J Elferich, U Shinde, G Thomas
Molecular biology of the cell 23 (11), 2184-2197, 2012
HIV-1 Nef: a master manipulator of the membrane trafficking machinery mediating immune evasion
EN Pawlak, JD Dikeakos
Biochimica et Biophysica Acta (BBA)-General Subjects 1850 (4), 733-741, 2015
HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling
BS Dirk, EN Pawlak, AL Johnson, LR Van Nynatten, RA Jacob, B Heit, ...
Scientific reports 6 (1), 37021, 2016
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster …
NW Werneburg, SF Bronk, ME Guicciardi, L Thomas, JD Dikeakos, ...
Journal of Biological Chemistry 287 (29), 24427-24437, 2012
The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest
KM Atkins, LL Thomas, J Barroso-Gonzalez, L Thomas, S Auclair, J Yin, ...
Cell reports 8 (5), 1545-1557, 2014
KIM-1/TIM-1 is a receptor for SARS-CoV-2 in lung and kidney
T Ichimura, Y Mori, P Aschauer, KM Padmanabha Das, RF Padera, ...
MedRxiv 2020, 2020
Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease
JD Dikeakos, P Di Lello, MJ Lacombe, R Ghirlando, P Legault, ...
Proceedings of the National Academy of Sciences 106 (18), 7408-7413, 2009
MIiSR: molecular interactions in super-resolution imaging enables the analysis of protein interactions, dynamics and formation of multi-protein structures
FA Caetano, BS Dirk, JHK Tam, PC Cavanagh, M Goiko, SSG Ferguson, ...
PLoS computational biology 11 (12), e1004634, 2015
PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism
JD Dikeakos, C Mercure, MJ Lacombe, NG Seidah, TL Reudelhuber
The FEBS journal 274 (16), 4094-4102, 2007
A hydrophobic patch in a charged α-helix is sufficient to target proteins to dense core secretory granules
JD Dikeakos, MJ Lacombe, C Mercure, M Mireuta, TL Reudelhuber
Journal of Biological Chemistry 282 (2), 1136-1143, 2007
The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells
EN Pawlak, BS Dirk, RA Jacob, AL Johnson, JD Dikeakos
Retrovirology 15 (1), 1-22, 2018
Interferon-induced HERC5 is evolving under positive selection and inhibits HIV-1 particle production by a novel mechanism targeting Rev/RRE-dependent RNA nuclear export
MW Woods, JG Tong, SK Tom, PA Szabo, PC Cavanagh, JD Dikeakos, ...
Retrovirology 11 (1), 1-17, 2014
Therapeutic control of leishmaniasis by inhibitors of the mammalian target of rapamycin
F Khadir, CR Shaler, A Oryan, PT Rudak, DM Mazzuca, T Taheri, ...
PLoS Neglected Tropical Diseases 12 (8), e0006701, 2018
Soluble CD93 is an apoptotic cell opsonin recognized by αxβ2
JWD Blackburn, DHC Lau, EY Liu, J Ellins, AM Vrieze, EN Pawlak, ...
European Journal of Immunology 49 (4), 600-610, 2019
HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4+ T Cells
J Prévost, CR Edgar, J Richard, SM Trothen, RA Jacob, MJ Mumby, ...
Journal of Virology 94 (7), e01999-19, 2020
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