Jimmy Dikeakos
Jimmy Dikeakos
Associate Professor
Verified email at uwo.ca
Cited by
Cited by
Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53
P Di Lello, LMM Jenkins, TN Jones, BD Nguyen, T Hara, H Yamaguchi, ...
Molecular cell 22 (6), 731-740, 2006
Sending proteins to dense core secretory granules: still a lot to sort out
JD Dikeakos, TL Reudelhuber
The Journal of cell biology 177 (2), 191-196, 2007
Small Molecule Inhibition of HIV-1–Induced MHC-I Down-Regulation Identifies a Temporally Regulated Switch in Nef Action
JD Dikeakos, KM Atkins, L Thomas, L Emert-Sedlak, IJL Byeon, J Jung, ...
Molecular biology of the cell 21 (19), 3279-3292, 2010
An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I
JD Dikeakos, L Thomas, G Kwon, J Elferich, U Shinde, G Thomas
Molecular biology of the cell 23 (11), 2184-2197, 2012
HIV-1 Nef: a master manipulator of the membrane trafficking machinery mediating immune evasion
EN Pawlak, JD Dikeakos
Biochimica et Biophysica Acta (BBA)-General Subjects 1850 (4), 733-741, 2015
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster …
NW Werneburg, SF Bronk, ME Guicciardi, L Thomas, JD Dikeakos, ...
Journal of Biological Chemistry 287 (29), 24427-24437, 2012
HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling
BS Dirk, EN Pawlak, AL Johnson, LR Van Nynatten, RA Jacob, B Heit, ...
Scientific reports 6 (1), 1-13, 2016
The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest
KM Atkins, LL Thomas, J Barroso-González, L Thomas, S Auclair, J Yin, ...
Cell reports 8 (5), 1545-1557, 2014
Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease
JD Dikeakos, P Di Lello, MJ Lacombe, R Ghirlando, P Legault, ...
Proceedings of the National Academy of Sciences 106 (18), 7408-7413, 2009
Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2
R Gasser, M Cloutier, J Prévost, C Fink, É Ducas, S Ding, N Dussault, ...
Cell reports 34 (9), 108790, 2021
PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism
JD Dikeakos, C Mercure, MJ Lacombe, NG Seidah, TL Reudelhuber
The FEBS journal 274 (16), 4094-4102, 2007
A hydrophobic patch in a charged α-helix is sufficient to target proteins to dense core secretory granules
JD Dikeakos, MJ Lacombe, C Mercure, M Mireuta, TL Reudelhuber
Journal of Biological Chemistry 282 (2), 1136-1143, 2007
MIiSR: molecular interactions in super-resolution imaging enables the analysis of protein interactions, dynamics and formation of multi-protein structures
FA Caetano, BS Dirk, JHK Tam, PC Cavanagh, M Goiko, SSG Ferguson, ...
PLoS computational biology 11 (12), e1004634, 2015
Modulation of secretory granule-targeting efficiency by cis and trans compounding of sorting signals
MJ Lacombe, C Mercure, JD Dikeakos, TL Reudelhuber
Journal of Biological Chemistry 280 (6), 4803-4807, 2005
Interferon-induced HERC5 is evolving under positive selection and inhibits HIV-1 particle production by a novel mechanism targeting Rev/RRE-dependent RNA nuclear export
MW Woods, JG Tong, SK Tom, PA Szabo, PC Cavanagh, JD Dikeakos, ...
Retrovirology 11 (1), 1-17, 2014
The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells
EN Pawlak, BS Dirk, RA Jacob, AL Johnson, JD Dikeakos
Retrovirology 15 (1), 1-22, 2018
Therapeutic control of leishmaniasis by inhibitors of the mammalian target of rapamycin
F Khadir, CR Shaler, A Oryan, PT Rudak, DM Mazzuca, T Taheri, ...
PLoS neglected tropical diseases 12 (8), e0006701, 2018
The C‐terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro
N Rabah, D Gauthier, JD Dikeakos, TL Reudelhuber, C Lazure
The FEBS journal 274 (13), 3482-3491, 2007
Antagonistic coevolution of MER tyrosine kinase expression and function
AL Evans, JWD Blackburn, K Taruc, A Kipp, BS Dirk, NR Hunt, SD Barr, ...
Molecular biology and evolution 34 (7), 1613-1628, 2017
Viral bimolecular fluorescence complementation: a novel tool to study intracellular vesicular trafficking pathways
BS Dirk, RA Jacob, AL Johnson, EN Pawlak, PC Cavanagh, ...
PLoS One 10 (4), e0125619, 2015
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