Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma RE Davis, VN Ngo, G Lenz, P Tolar, RM Young, PB Romesser, ... Nature 463 (7277), 88-92, 2010 | 1883 | 2010 |
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses D Anastasiou, G Poulogiannis, JM Asara, MB Boxer, J Jiang, M Shen, ... Science 334 (6060), 1278-1283, 2011 | 1217 | 2011 |
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages EM Palsson-McDermott, AM Curtis, G Goel, MAR Lauterbach, FJ Sheedy, ... Cell metabolism 21 (1), 65-80, 2015 | 1102 | 2015 |
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ... Nature chemical biology 8 (10), 839-847, 2012 | 771 | 2012 |
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells LA Mathews Griner, R Guha, P Shinn, RM Young, JM Keller, D Liu, ... Proceedings of the National Academy of Sciences 111 (6), 2349-2354, 2014 | 404 | 2014 |
Evaluation of Substituted N,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase MB Boxer, J Jiang, MG Vander Heiden, M Shen, AP Skoumbourdis, ... Journal of medicinal chemistry 53 (3), 1048-1055, 2010 | 188 | 2010 |
Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion J Feng, CD Petersen, DH Coy, JK Jiang, CJ Thomas, MR Pollak, ... Proceedings of the National Academy of Sciences 107 (41), 17791-17796, 2010 | 151 | 2010 |
Evaluation of thieno [3, 2-b] pyrrole [3, 2-d] pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase J Jiang, MB Boxer, MG Vander Heiden, M Shen, AP Skoumbourdis, ... Bioorganic & medicinal chemistry letters 20 (11), 3387-3393, 2010 | 146 | 2010 |
Examining the Chirality, Conformation and Selective Kinase Inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3 … J Jiang, K Ghoreschi, F Deflorian, Z Chen, M Perreira, M Pesu, J Smith, ... Journal of medicinal chemistry 51 (24), 8012-8018, 2008 | 143 | 2008 |
Selective targeting of ITK blocks multiple steps of HIV replication JA Readinger, GM Schiralli, JK Jiang, CJ Thomas, A August, ... Proceedings of the National Academy of Sciences 105 (18), 6684-6689, 2008 | 134 | 2008 |
A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin … H Jäschke, S Neumann, S Moore, CJ Thomas, AO Colson, S Costanzi, ... Journal of Biological Chemistry 281 (15), 9841-9844, 2006 | 116 | 2006 |
A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism S Neumann, G Kleinau, S Costanzi, S Moore, J Jiang, BM Raaka, ... Endocrinology 149 (12), 5945-5950, 2008 | 113 | 2008 |
TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation R Nayar, M Enos, A Prince, HM Shin, S Hemmers, J Jiang, U Klein, ... Proceedings of the National Academy of Sciences 109 (41), E2794-E2802, 2012 | 110 | 2012 |
A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+ J Hu, SJ McLarnon, S Mora, J Jiang, C Thomas, KA Jacobson, ... Journal of Biological Chemistry 280 (6), 5113-5120, 2005 | 109 | 2005 |
Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure− activity relationships and selective … S Moore, H Jaeschke, G Kleinau, S Neumann, S Costanzi, J Jiang, ... Journal of medicinal chemistry 49 (13), 3888-3896, 2006 | 104 | 2006 |
Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity G Lu, E Lomonosova, X Cheng, EA Moran, MJ Meyers, SFJ Le Grice, ... Antimicrobial agents and chemotherapy 59 (2), 1070-1079, 2015 | 93 | 2015 |
Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H S Chung, DM Himmel, JK Jiang, K Wojtak, JD Bauman, JW Rausch, ... Journal of medicinal chemistry 54 (13), 4462-4473, 2011 | 90 | 2011 |
“Reversine” and Its 2-Substituted Adenine Derivatives as Potent and Selective A3 Adenosine Receptor Antagonists M Perreira, J Jiang, AM Klutz, ZG Gao, A Shainberg, C Lu, CJ Thomas, ... Journal of medicinal chemistry 48 (15), 4910-4918, 2005 | 88 | 2005 |
RUC-4: a novel αIIbβ3 antagonist for prehospital therapy of myocardial infarction J Li, S Vootukuri, Y Shang, A Negri, J Jiang, M Nedelman, TG Diacovo, ... Arteriosclerosis, thrombosis, and vascular biology 34 (10), 2321-2329, 2014 | 85 | 2014 |
CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP W Ju, M Zhang, J Jiang, CJ Thomas, U Oh, BR Bryant, J Chen, N Sato, ... Blood, The Journal of the American Society of Hematology 117 (6), 1938-1946, 2011 | 80 | 2011 |