|Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells|
A Rezania, JE Bruin, P Arora, A Rubin, I Batushansky, A Asadi, S O'dwyer, ...
Nature biotechnology 32 (11), 1121, 2014
|Maturation of human embryonic stem cell–derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice|
A Rezania, JE Bruin, MJ Riedel, M Mojibian, A Asadi, J Xu, R Gauvin, ...
Diabetes 61 (8), 2016-2029, 2012
|Long-term consequences of fetal and neonatal nicotine exposure: a critical review|
JE Bruin, HC Gerstein, AC Holloway
Toxicological sciences 116 (2), 364-374, 2010
|Enrichment of human embryonic stem cell‐derived NKX6. 1‐expressing pancreatic progenitor cells accelerates the maturation of insulin‐secreting cells in vivo|
A Rezania, JE Bruin, J Xu, K Narayan, JK Fox, JJ O'Neil, TJ Kieffer
Stem cells 31 (11), 2432-2442, 2013
|Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice|
JE Bruin, A Rezania, J Xu, K Narayan, JK Fox, JJ O’Neil, TJ Kieffer
Diabetologia 56 (9), 1987-1998, 2013
|Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells|
JE Bruin, S Erener, J Vela, X Hu, JD Johnson, HT Kurata, FC Lynn, ...
Stem cell research 12 (1), 194-208, 2014
|Reduced insulin production relieves endoplasmic reticulum stress and induces β cell proliferation|
M Szabat, MM Page, E Panzhinskiy, S Skovsų, M Mojibian, ...
Cell metabolism 23 (1), 179-193, 2016
|Maternal nicotine exposure increases oxidative stress in the offspring|
JE Bruin, MA Petre, MA Lehman, S Raha, HC Gerstein, KM Morrison, ...
Free Radical Biology and Medicine 44 (11), 1919-1925, 2008
|Fetal and neonatal nicotine exposure and postnatal glucose homeostasis: identifying critical windows of exposure|
JE Bruin, LD Kellenberger, HC Gerstein, KM Morrison, AC Holloway
Journal of Endocrinology 194 (1), 171-178, 2007
|Increased pancreatic beta-cell apoptosis following fetal and neonatal exposure to nicotine is mediated via the mitochondria|
JE Bruin, HC Gerstein, KM Morrison, AC Holloway
Toxicological Sciences 103 (2), 362-370, 2008
|Fetal and neonatal nicotine exposure in Wistar rats causes progressive pancreatic mitochondrial damage and beta cell dysfunction|
JE Bruin, MA Petre, S Raha, KM Morrison, HC Gerstein, AC Holloway
PloS one 3 (10), e3371, 2008
|Treating diet-induced diabetes and obesity with human embryonic stem cell-derived pancreatic progenitor cells and antidiabetic drugs|
JE Bruin, N Saber, N Braun, JK Fox, M Mojibian, A Asadi, C Drohan, ...
Stem cell reports 4 (4), 605-620, 2015
|Accelerated maturation of human stem cell-derived pancreatic progenitor cells into insulin-secreting cells in immunodeficient rats relative to mice|
JE Bruin, A Asadi, JK Fox, S Erener, A Rezania, TJ Kieffer
Stem cell reports 5 (6), 1081-1096, 2015
|The role of dysregulated glucose metabolism in epithelial ovarian cancer|
LD Kellenberger, JE Bruin, J Greenaway, NE Campbell, RA Moorehead, ...
Journal of oncology 2010, 2010
|Replacing and safeguarding pancreatic β cells for diabetes|
JE Bruin, A Rezania, TJ Kieffer
Science translational medicine 7 (316), 316ps23-316ps23, 2015
|Differentiation of human pluripotent stem cells into β-cells: Potential and challenges|
N Quiskamp, JE Bruin, TJ Kieffer
Best Practice & research Clinical endocrinology & metabolism 29 (6), 833-847, 2015
|Implanted islets in the anterior chamber of the eye are prone to autoimmune attack in a mouse model of diabetes|
M Mojibian, B Harder, A Hurlburt, JE Bruin, A Asadi, TJ Kieffer
Diabetologia 56 (10), 2213-2221, 2013
|Rosiglitazone prevents diabetes by increasing beta‐cell mass in an animal model of type 2 diabetes characterized by reduced beta‐cell mass at birth|
AC Holloway, JJ Petrik, JE Bruin, HC Gerstein
Diabetes, Obesity and Metabolism 10 (9), 763-771, 2008
|Characterization of antibodies to products of proinsulin processing using immunofluorescence staining of pancreas in multiple species|
A Asadi, JE Bruin, TJ Kieffer
Journal of Histochemistry & Cytochemistry 63 (8), 646-662, 2015
|Effect of in utero and lactational nicotine exposure on the male reproductive tract in peripubertal and adult rats|
A Lagunov, M Anzar, JC Sadeu, MIR Khan, JE Bruin, AK Woynillowicz, ...
Reproductive toxicology 31 (4), 418-423, 2011