Jennifer E Bruin
Jennifer E Bruin
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Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
A Rezania, JE Bruin, P Arora, A Rubin, I Batushansky, A Asadi, S O'dwyer, ...
Nature biotechnology 32 (11), 1121-1133, 2014
Maturation of human embryonic stem cell–derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice
A Rezania, JE Bruin, MJ Riedel, M Mojibian, A Asadi, J Xu, R Gauvin, ...
Diabetes 61 (8), 2016-2029, 2012
Long-term consequences of fetal and neonatal nicotine exposure: a critical review
JE Bruin, HC Gerstein, AC Holloway
Toxicological sciences 116 (2), 364-374, 2010
Enrichment of human embryonic stem cell-derived NKX6. 1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo
A Rezania, JE Bruin, J Xu, K Narayan, JK Fox, JJ O'Neil, TJ Kieffer
Stem cells 31 (11), 2432-2442, 2013
Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice
JE Bruin, A Rezania, J Xu, K Narayan, JK Fox, JJ O’Neil, TJ Kieffer
Diabetologia 56, 1987-1998, 2013
Reduced insulin production relieves endoplasmic reticulum stress and induces β cell proliferation
M Szabat, MM Page, E Panzhinskiy, S Skovsų, M Mojibian, ...
Cell metabolism 23 (1), 179-193, 2016
Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells
JE Bruin, S Erener, J Vela, X Hu, JD Johnson, HT Kurata, FC Lynn, ...
Stem cell research 12 (1), 194-208, 2014
Fetal and neonatal nicotine exposure and postnatal glucose homeostasis: identifying critical windows of exposure
JE Bruin, LD Kellenberger, HC Gerstein, KM Morrison, AC Holloway
Journal of Endocrinology 194 (1), 171-178, 2007
Fetal and neonatal nicotine exposure in Wistar rats causes progressive pancreatic mitochondrial damage and beta cell dysfunction
JE Bruin, MA Petre, S Raha, KM Morrison, HC Gerstein, AC Holloway
PloS one 3 (10), e3371, 2008
Maternal nicotine exposure increases oxidative stress in the offspring
JE Bruin, MA Petre, MA Lehman, S Raha, HC Gerstein, KM Morrison, ...
Free Radical Biology and Medicine 44 (11), 1919-1925, 2008
Increased pancreatic beta-cell apoptosis following fetal and neonatal exposure to nicotine is mediated via the mitochondria
JE Bruin, HC Gerstein, KM Morrison, AC Holloway
Toxicological Sciences 103 (2), 362-370, 2008
Treating diet-induced diabetes and obesity with human embryonic stem cell-derived pancreatic progenitor cells and antidiabetic drugs
JE Bruin, N Saber, N Braun, JK Fox, M Mojibian, A Asadi, C Drohan, ...
Stem cell reports 4 (4), 605-620, 2015
Accelerated maturation of human stem cell-derived pancreatic progenitor cells into insulin-secreting cells in immunodeficient rats relative to mice
JE Bruin, A Asadi, JK Fox, S Erener, A Rezania, TJ Kieffer
Stem cell reports 5 (6), 1081-1096, 2015
The role of dysregulated glucose metabolism in epithelial ovarian cancer
LD Kellenberger, JE Bruin, J Greenaway, NE Campbell, RA Moorehead, ...
Journal of oncology 2010, 2010
Differentiation of human pluripotent stem cells into β-cells: Potential and challenges
N Quiskamp, JE Bruin, TJ Kieffer
Best Practice & research Clinical endocrinology & metabolism 29 (6), 833-847, 2015
Replacing and safeguarding pancreatic β cells for diabetes
JE Bruin, A Rezania, TJ Kieffer
Science translational medicine 7 (316), 316ps23-316ps23, 2015
Sex Differences in Maturation of Human Embryonic Stem Cell–Derived β Cells in Mice
N Saber, JE Bruin, S O’Dwyer, H Schuster, A Rezania, TJ Kieffer
Endocrinology 159 (4), 1827-1841, 2018
Implanted islets in the anterior chamber of the eye are prone to autoimmune attack in a mouse model of diabetes
M Mojibian, B Harder, A Hurlburt, JE Bruin, A Asadi, TJ Kieffer
Diabetologia 56, 2213-2221, 2013
Functional cytochrome P450 1A enzymes are induced in mouse and human islets following pollutant exposure
M Ibrahim, EM MacFarlane, G Matteo, MP Hoyeck, KRC Rick, S Farokhi, ...
Diabetologia 63, 162-178, 2020
Hypothyroidism impairs human stem cell–derived pancreatic progenitor cell maturation in mice
JE Bruin, N Saber, S O’Dwyer, JK Fox, M Mojibian, P Arora, A Rezania, ...
Diabetes 65 (5), 1297-1309, 2016
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