| Structure of C3b in complex with CRIg gives insights into regulation of complement activation C Wiesmann, KJ Katschke, JP Yin, KY Helmy, M Steffek, WJ Fairbrother, ... Nature 444 (7116), 217-220, 2006 | 283 | 2006 |
| Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab L Rougé, N Chiang, M Steffek, C Kugel, TI Croll, C Tam, A Estevez, ... Science 367 (6483), 1224-1230, 2020 | 119 | 2020 |
| ATP-dependent L-cysteine: 1D-myo-inosityl 2-amino-2-deoxy-α-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases D Sareen, M Steffek, GL Newton, RC Fahey Biochemistry 41 (22), 6885-6890, 2002 | 111 | 2002 |
| A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis KJ Katschke Jr, KY Helmy, M Steffek, H Xi, JP Yin, WP Lee, P Gribling, ... The Journal of experimental medicine 204 (6), 1319-1325, 2007 | 107 | 2007 |
| Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors JJ Kulagowski, W Blair, RJ Bull, C Chang, G Deshmukh, HJ Dyke, ... Journal of Medicinal Chemistry 55 (12), 5901-5921, 2012 | 103 | 2012 |
| Small molecule dysregulation of TEAD lipidation induces a dominant-negative inhibition of hippo pathway signaling JK Holden, JJ Crawford, CL Noland, S Schmidt, JR Zbieg, JA Lacap, ... Cell reports 31 (12), 2020 | 87 | 2020 |
| Discovery of novel pyrazolo [1, 5-a] pyrimidines as potent pan-Pim inhibitors by structure-and property-based drug design X Wang, S Magnuson, R Pastor, E Fan, H Hu, V Tsui, W Deng, J Murray, ... Bioorganic & medicinal chemistry letters 23 (11), 3149-3153, 2013 | 84 | 2013 |
| Complement receptor of the Ig superfamily enhances complement-mediated phagocytosis in a subpopulation of tissue resident macrophages NN Gorgani, JQ He, KJ Katschke, KY Helmy, H Xi, M Steffek, PE Hass, ... The Journal of Immunology 181 (11), 7902-7908, 2008 | 84 | 2008 |
| Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2 M Zak, CA Hurley, SI Ward, P Bergeron, K Barrett, M Balazs, WS Blair, ... Journal of medicinal chemistry 56 (11), 4764-4785, 2013 | 77 | 2013 |
| Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase M Steffek, GL Newton, Y Av-Gay, RC Fahey Biochemistry 42 (41), 12067-12076, 2003 | 77 | 2003 |
| Structural and functional analysis of a C3b-specific antibody that selectively inhibits the alternative pathway of complement KJ Katschke, S Stawicki, J Yin, M Steffek, H Xi, L Sturgeon, PE Hass, ... Journal of biological chemistry 284 (16), 10473-10479, 2009 | 70 | 2009 |
| Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization NPD Liau, TJ Wendorff, JG Quinn, M Steffek, W Phung, P Liu, J Tang, ... Nature structural & molecular biology 27 (2), 134-141, 2020 | 68 | 2020 |
| Targeted Mutagenesis of the Mycobacterium smegmatis mca Gene, Encoding a Mycothiol-Dependent Detoxification Protein M Rawat, M Uppal, G Newton, M Steffek, RC Fahey, Y Av-Gay Journal of bacteriology 186 (18), 6050-6058, 2004 | 68 | 2004 |
| Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2 M Zak, R Mendonca, M Balazs, K Barrett, P Bergeron, WS Blair, C Chang, ... Journal of Medicinal Chemistry 55 (13), 6176-6193, 2012 | 58 | 2012 |
| Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling AH Phillips, Y Zhang, CN Cunningham, L Zhou, WF Forrest, PS Liu, ... Proceedings of the National Academy of Sciences 110 (28), 11379-11384, 2013 | 53 | 2013 |
| Prevention and treatment of complement-associated eye conditions P Hass, Y Jianping, K Katschke, M Steffek, C Wiesmann, MVL Campagne US Patent 8,007,791, 2011 | 45 | 2011 |
| Prevention and treatment of complement-associated eye conditions P Hass, Y Jianping, K Katschke, M Steffek, C Wiesmann, MVL Campagne US Patent 8,007,791, 2011 | 45 | 2011 |
| Prevention and treatment of complement-associated eye conditions P Hass, Y Jianping, K Katschke, M Steffek, C Wiesmann, MVL Campagne US Patent 8,007,791, 2011 | 45 | 2011 |
| Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6 CE Heise, J Murray, KE Augustyn, B Bravo, P Chugha, F Cohen, ... PLoS One 7 (12), e50864, 2012 | 44 | 2012 |
| Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization K Stanger, M Steffek, L Zhou, CD Pozniak, C Quan, Y Franke, J Tom, ... Nature chemical biology 8 (7), 655-660, 2012 | 41 | 2012 |
