Rama Khokha
Rama Khokha
Professor, University of Toronto, Ontario cancer institute
Verified email at
Cited by
Cited by
Regulation of cancer cell migration and bone metastasis by RANKL
DH Jones, T Nakashima, OH Sanchez, I Kozieradzki, SV Komarova, ...
Nature 440 (7084), 692-696, 2006
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development
JE Fata, YY Kong, J Li, T Sasaki, J Irie-Sasaki, RA Moorehead, R Elliott, ...
Cell 103 (1), 41-50, 2000
Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression
IS Harris, AE Treloar, S Inoue, M Sasaki, C Gorrini, KC Lee, KY Yung, ...
Cancer cell 27 (2), 211-222, 2015
Progesterone induces adult mammary stem cell expansion
PA Joshi, HW Jackson, AG Beristain, MA Di Grappa, PA Mote, CL Clarke, ...
Nature 465 (7299), 803-807, 2010
Suppression of tumor growth and metastasis in Mgat5-deficient mice
M Granovsky, J Fata, J Pawling, WJ Muller, R Khokha, JW Dennis
Nature medicine 6 (3), 306-312, 2000
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer
D Schramek, A Leibbrandt, V Sigl, L Kenner, JA Pospisilik, HJ Lee, ...
Nature 468 (7320), 98-102, 2010
Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.
KJ Leco, R Khokha, N Pavloff, SP Hawkes, DR Edwards
Journal of Biological Chemistry 269 (12), 9352-9360, 1994
Metalloproteinases and their natural inhibitors in inflammation and immunity
R Khokha, A Murthy, A Weiss
Nature Reviews Immunology 13 (9), 649-665, 2013
Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells
R Khokha, P Waterhouse, S Yagel, PK Lala, CM Overall, G Norton, ...
Science 243 (4893), 947-950, 1989
Tumor necrosis factor-α mediates cardiac remodeling and ventricular dysfunction after pressure overload state
M Sun, M Chen, F Dawood, U Zurawska, JY Li, T Parker, Z Kassiri, ...
Circulation 115 (11), 1398-1407, 2007
The association of measured breast tissue characteristics with mammographic density and other risk factors for breast cancer
T Li, L Sun, N Miller, T Nicklee, J Woo, L Hulse-Smith, MS Tsao, R Khokha, ...
Cancer Epidemiology Biomarkers & Prevention 14 (2), 343-349, 2005
TIMPs: versatile extracellular regulators in cancer
HW Jackson, V Defamie, P Waterhouse, R Khokha
Nature Reviews Cancer 17 (1), 38-53, 2017
RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis
A Hakem, O Sanchez-Sweatman, A You-Ten, G Duncan, A Wakeham, ...
Genes & development 19 (17), 1974-1979, 2005
iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS
DR McIlwain, PA Lang, T Maretzky, K Hamada, K Ohishi, SK Maney, ...
Science 335 (6065), 229-232, 2012
Molecular mechanisms of tumor invasion and metastasis: an integrated view
RA Cairns, R Khokha, RP Hill
Current molecular medicine 3 (7), 659-671, 2003
Steps in tumor metastasis: new concepts from intravital videomicroscopy
AF Chambers, IC MacDonald, EE Schmidt, S Koop, VL Morris, R Khokha, ...
Cancer and Metastasis Reviews 14, 279-301, 1995
Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution
S Schenk, E Hintermann, M Bilban, N Koshikawa, C Hojilla, R Khokha, ...
The Journal of cell biology 161 (1), 197-209, 2003
Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3)
KJ Leco, P Waterhouse, OH Sanchez, KLM Gowing, AR Poole, ...
The Journal of clinical investigation 108 (6), 817-829, 2001
Abnormal TNF activity in Timp3−/− mice leads to chronic hepatic inflammation and failure of liver regeneration
FF Mohammed, DS Smookler, SEM Taylor, B Fingleton, Z Kassiri, ...
Nature genetics 36 (9), 969-977, 2004
Matrix metalloproteinases and their tissue inhibitors direct cell fate during cancer development
CV Hojilla, FF Mohammed, R Khokha
British journal of cancer 89 (10), 1817-1821, 2003
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