Laurence Yang
Laurence Yang
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EMILiO: a fast algorithm for genome-scale strain design
L Yang, WR Cluett, R Mahadevan
Metabolic engineering 13 (3), 272-281, 2011
Dynamic strain scanning optimization: an efficient strain design strategy for balanced yield, titer, and productivity. DySScO strategy for strain design
K Zhuang, L Yang, WR Cluett, R Mahadevan
BMC biotechnology 13 (1), 8, 2013
Characterizing Strain Variation in Engineered E. coli Using a Multi-Omics-Based Workflow
E Brunk, KW George, J Alonso-Gutierrez, M Thompson, E Baidoo, ...
Cell systems 2 (5), 335-346, 2016
COBRAme: A computational framework for genome-scale models of metabolism and gene expression
CJ Lloyd, A Ebrahim, L Yang, ZA King, E Catoiu, EJ O’Brien, JK Liu, ...
PLoS computational biology 14 (7), e1006302, 2018
Global transcriptional regulatory network for Escherichia coli robustly connects gene expression to transcription factor activities
X Fang, A Sastry, N Mih, D Kim, J Tan, JT Yurkovich, CJ Lloyd, Y Gao, ...
Proceedings of the National Academy of Sciences 114 (38), 10286-10291, 2017
solveME: fast and reliable solution of nonlinear ME models
L Yang, D Ma, A Ebrahim, CJ Lloyd, MA Saunders, BO Palsson
BMC Bioinformatics 17 (1), 391, 2016
Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance
ES Kavvas, E Catoiu, N Mih, JT Yurkovich, Y Seif, N Dillon, D Heckmann, ...
Nature communications 9 (1), 1-9, 2018
Systems biology definition of the core proteome of metabolism and expression is consistent with high-throughput data
L Yang, J Tan, EJ O’Brien, JM Monk, D Kim, HJ Li, P Charusanti, ...
Proceedings of the National Academy of Sciences 112 (34), 10810-10815, 2015
Reliable and efficient solution of genome-scale models of Metabolism and macromolecular Expression
D Ma, L Yang, RMT Fleming, I Thiele, BO Palsson, MA Saunders
Scientific Reports 7, 40863, 2017
Thermosensitivity of growth is determined by chaperone-mediated proteome reallocation
K Chen, Y Gao, N Mih, EJ O’Brien, L Yang, BO Palsson
Proceedings of the National Academy of Sciences 114 (43), 11548-11553, 2017
Quantitative time-course metabolomics in human red blood cells reveal the temperature dependence of human metabolic networks
JT Yurkovich, DC Zielinski, L Yang, G Paglia, O Rolfsson, ...
Journal of Biological Chemistry 292 (48), 19556-19564, 2017
Principles of proteome allocation are revealed using proteomic data and genome-scale models
L Yang, JT Yurkovich, CJ Lloyd, A Ebrahim, MA Saunders, BO Palsson
Scientific reports 6, 36734, 2016
A bilevel optimization algorithm to identify enzymatic capacity constraints in metabolic networks
L Yang, R Mahadevan, WR Cluett
Computers & Chemical Engineering 32 (9), 2072-2085, 2008
Systematic discovery of uncharacterized transcription factors in Escherichia coli K-12 MG1655
Y Gao, JT Yurkovich, SW Seo, I Kabimoldayev, A Dräger, K Chen, ...
Nucleic acids research 46 (20), 10682-10696, 2018
Thermodynamic analysis of regulation in metabolic networks using constraint-based modeling
S Garg, L Yang, R Mahadevan
BMC research notes 3 (1), 125, 2010
Characterizing metabolic pathway diversification in the context of perturbation size
L Yang, S Srinivasan, R Mahadevan, WR Cluett
Metabolic engineering 28, 114-122, 2015
The Escherichia coli transcriptome mostly consists of independently regulated modules
AV Sastry, Y Gao, R Szubin, Y Hefner, S Xu, D Kim, KS Choudhary, ...
Nature communications 10 (1), 1-14, 2019
DynamicME: dynamic simulation and refinement of integrated models of metabolism and protein expression
L Yang, A Ebrahim, CJ Lloyd, MA Saunders, BO Palsson
BMC systems biology 13 (1), 2, 2019
Modeling the multi-scale mechanisms of macromolecular resource allocation
L Yang, JT Yurkovich, ZA King, BO Palsson
Current opinion in microbiology 45, 8-15, 2018
Biomarkers are used to predict quantitative metabolite concentration profiles in human red blood cells
JT Yurkovich, L Yang, BO Palsson
PLoS computational biology 13 (3), e1005424, 2017
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