| Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration B Oosthuyse, L Moons, E Storkebaum, H Beck, D Nuyens, K Brusselmans, ... Nature genetics 28 (2), 131-138, 2001 | 1373 | 2001 |
| Neuroblastoma× spinal cord (NSC) hybrid cell lines resemble developing motor neurons NR Cashman, HD Durham, JK Blusztajn, K Oda, T Tabira, IT Shaw, ... Developmental dynamics 194 (3), 209-221, 1992 | 835 | 1992 |
| Neurologic sequelae of domoic acid intoxication due to the ingestion of contaminated mussels JS Teitelbaum, RJ Zatorre, S Carpenter, D Gendron, AC Evans, A Gjedde, ... New England Journal of Medicine 322 (25), 1781-1787, 1990 | 734 | 1990 |
| Iatrogenic Creutzfeldt–Jakob disease at the millennium P Brown, M Preece, JP Brandel, T Sato, L McShane, I Zerr, A Fletcher, ... Neurology 55 (8), 1075-1081, 2000 | 713 | 2000 |
| Nearly ubiquitous tissue distribution of the scrapie agent precursor protein PE Bendheim, HR Brown, RD Rudelli, LJ Scala, NL Goller, GY Wen, ... Neurology 42 (1), 149-149, 1992 | 548 | 1992 |
| Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis NJ Rutherford, YJ Zhang, M Baker, JM Gass, NCA Finch, YF Xu, ... PLoS genetics 4 (9), e1000193, 2008 | 545 | 2008 |
| Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and-independent mechanisms LI Grad, JJ Yerbury, BJ Turner, WC Guest, E Pokrishevsky, MA O’Neill, ... Proceedings of the National Academy of Sciences 111 (9), 3620-3625, 2014 | 471 | 2014 |
| Multiple sclerosis: Fas signaling in oligodendrocyte cell death SD D'Souza, B Bonetti, V Balasingam, NR Cashman, PA Barker, AB Troutt, ... The Journal of experimental medicine 184 (6), 2361-2370, 1996 | 465 | 1996 |
| Cellular isoform of the scrapie agent protein participates in lymphocyte activation NR Cashman, R Loertscher, J Nalbantoglu, I Shaw, RJ Kascsak, ... Cell 61 (1), 185-192, 1990 | 446 | 1990 |
| Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis R Rakhit, P Cunningham, A Furtos-Matei, S Dahan, XF Qi, JP Crow, ... Journal of Biological Chemistry 277 (49), 47551-47556, 2002 | 417 | 2002 |
| Monomeric Cu, Zn-superoxide Dismutase Is a Common Misfolding Intermediate in the Oxidation Models of Sporadic and Familial Amyotrophic Lateral Sclerosis*[boxs] R Rakhit, JP Crow, JR Lepock, LH Kondejewski, NR Cashman, ... Journal of Biological Chemistry 279 (15), 15499-15504, 2004 | 409 | 2004 |
| A double‐blind placebo‐controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis ALS CNTF Treatment Study Group Neurology 46 (5), 1244-1244, 1996 | 377 | 1996 |
| A prion protein epitope selective for the pathologically misfolded conformation E Paramithiotis, M Pinard, T Lawton, S LaBoissiere, VL Leathers, WQ Zou, ... Nature medicine 9 (7), 893-899, 2003 | 355 | 2003 |
| Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria C Vande Velde, TM Miller, NR Cashman, DW Cleveland Proceedings of the National Academy of Sciences 105 (10), 4022-4027, 2008 | 342 | 2008 |
| A controlled trial of recombinant methionyl human BDNF in ALS BDNF Study Group (Phase III) Neurology 52 (7), 1427-1427, 1999 | 339* | 1999 |
| Post‐poliomyelitis syndrome DA Trojan, NR Cashman Muscle & Nerve: Official Journal of the American Association of …, 2005 | 317 | 2005 |
| Clinical spectrum of amyotrophic lateral sclerosis (ALS) LI Grad, GA Rouleau, J Ravits, NR Cashman Cold Spring Harbor perspectives in medicine 7 (8), a024117, 2017 | 314 | 2017 |
| Intermolecular transmission of superoxide dismutase 1 misfolding in living cells LI Grad, WC Guest, A Yanai, E Pokrishevsky, MA O'Neill, E Gibbs, ... Proceedings of the National Academy of Sciences 108 (39), 16398-16403, 2011 | 311 | 2011 |
| An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS R Rakhit, J Robertson, CV Velde, P Horne, DM Ruth, J Griffin, ... Nature medicine 13 (6), 754-759, 2007 | 296 | 2007 |
| Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers IRA Mackenzie, P Frick, FA Grässer, TF Gendron, L Petrucelli, ... Acta neuropathologica 130, 845-861, 2015 | 284 | 2015 |
Steven PlotkinProfessor of Physics, Faculty of Cell and Developmental Biology, University of British ColumbiaVerified email at phas.ubc.ca
