| Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality J Ishizawa, SF Zarabi, RE Davis, O Halgas, T Nii, Y Jitkova, R Zhao, ... Cancer cell 35 (5), 721-737. e9, 2019 | 247 | 2019 |
| E1 Enzymes as Therapeutic Targets in Cancer SH Barghout, AD Schimmer Pharmacological Reviews 73 (1), 1-56, 2021 | 72 | 2021 |
| Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia SH Barghout, PS Patel, X Wang, GW Xu, S Kavanagh, O Halgas, ... Leukemia 33 (1), 37, 2019 | 66 | 2019 |
| Disrupting mitochondrial copper distribution inhibits leukemic stem cell self-renewal RP Singh, DV Jeyaraju, V Voisin, R Hurren, C Xu, JR Hawley, ... Cell Stem Cell 26 (6), 926-937. e10, 2020 | 43 | 2020 |
| Elevated β-catenin activity contributes to carboplatin resistance in A2780cp ovarian cancer cells SH Barghout, N Zepeda, Z Xu, H Steed, CH Lee, YX Fu Biochemical and biophysical research communications 468 (1-2), 173-8, 2015 | 43 | 2015 |
| RUNX3 contributes to carboplatin resistance in epithelial ovarian cancer cells SH Barghout, N Zepeda, K Vincent, AK Azad, Z Xu, C Yang, H Steed, ... Gynecologic oncology 138 (3), 647-655, 2015 | 34 | 2015 |
| A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity SH Barghout, A Aman, K Nouri, Z Blatman, K Arevalo, GE Thomas, ... JCI insight 6 (5), 2021 | 22 | 2021 |
| The thymidine dideoxynucleoside analog, alovudine, inhibits the mitochondrial DNA polymerase γ, impairs oxidative phosphorylation and promotes monocytic differentiation in … D Yehudai, SU Liyanage, R Hurren, B Rizoska, M Albertella, M Gronda, ... haematologica 104 (5), 963, 2019 | 17 | 2019 |
| The ubiquitin-activating enzyme, UBA1, as a novel therapeutic target for AML SH Barghout, AD Schimmer Oncotarget 9 (76), 34198-34199, 2018 | 17 | 2018 |
| PRMT5 regulates ATF4 transcript splicing and oxidative stress response MM Szewczyk, GM Luciani, V Vu, A Murison, D Dilworth, SH Barghout, ... Redox biology 51, 102282, 2022 | 16 | 2022 |
| Chemical biology and pharmacology of histone lysine methylation inhibitors SH Barghout, RAC Machado, D Barsyte-Lovejoy Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1865 (6), 194840, 2022 | 15 | 2022 |
| Targeting the ubiquitin-proteasome system using the UBA1 inhibitor TAK-243 is a potential therapeutic strategy for small cell lung cancer S Majeed, MK Aparnathi, KCJ Nixon, V Venkatasubramanian, F Rahman, ... Clinical Cancer Research 28 (9), 1966–1978, 2022 | 14 | 2022 |
| Targeted Protein Degradation: An Emerging Therapeutic Strategy in Cancer SH Barghout Anti-cancer Agents in Medicinal Chemistry, 2020 | 12 | 2020 |
| AML refractory to primary induction with Ida-FLAG has a poor clinical outcome S Kavanagh, E Heath, R Hurren, M Gronda, SH Barghout, SU Liyanage, ... Leukemia Research 68, 22-28, 2018 | 7 | 2018 |
| Combined Targeting of the Glutathione and Thioredoxin Antioxidant Systems in Pancreatic Cancer F Fazzari, S Chow, M Cheung, SH Barghout, AD Schimmer, Q Chang, ... ACS Pharmacology & Translational Science, 1-9, 2022 | 4 | 2022 |
| New frontiers in the discovery and development of PROTACs SH Barghout Anti-cancer Agents in Medicinal Chemistry, 2022 | 4 | 2022 |
| Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism RP Singh, DV Jeyaraju, V Voisin, C Xu, SH Barghout, DH Khan, R Hurren, ... Blood 132 (Suppl 1), 1339-1339, 2018 | 4 | 2018 |
| Combinatorial anticancer drug screen identifies off-target effects of epigenetic chemical probes SH Barghout, MK Mann, A Aman, Y Yu, MG Alteen, AD Schimmer, ... ACS Chemical Biology 17 (10), 2801-2816, 2022 | 3 | 2022 |
| HiBiT Cellular Thermal Shift Assay (HiBiT CETSA) S Ramachandran, M Szewczyk, SH Barghout, A Ciulli, D Barsyte-Lovejoy, ... Chemogenomics: Methods and Protocols, 149-165, 2023 | 2 | 2023 |
| A Genome-Wide CRISPR/Cas9 Knockout Screen Identifies BEND3 As a Determinant of Sensitivity to UBA1 Inhibition in Acute Myeloid Leukemia SH Barghout, N MacLean, GW Xu, G Thomas, Z Blatman, R Hurren, ... Blood 132 (Suppl 1), 1350-1350, 2018 | 2 | 2018 |
aaron schimmerVerified email at uhn.ca
