| Oral IDN‐6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C PJ Pockros, ER Schiff, ML Shiffman, JG McHutchison, RG Gish, NH Afdhal, ... Hepatology 46 (2), 324-329, 2007 | 230 | 2007 |
| Correlating Hydration Shell Structure with Amino Acid Hydrophobicity D Hecht, L Tadesse, L Walters Journal of the American Chemical Society 115, 3336-3337, 1993 | 96 | 1993 |
| CUREs in biochemistry—where we are and where we should go JK Bell, TT Eckdahl, DA Hecht, PJ Killion, J Latzer, TL Mans, JJ Provost, ... Biochemistry and Molecular Biology Education 45 (1), 7-12, 2017 | 70 | 2017 |
| Exploiting atropisomerism to increase the target selectivity of kinase inhibitors DE Smith, I Marquez, ME Lokensgard, AL Rheingold, DA Hecht, ... Angewandte Chemie 127 (40), 11920-11925, 2015 | 69 | 2015 |
| Computational intelligence methods for docking scores D Hecht, GB Fogel Current Computer-Aided Drug Design 5 (1), 56-68, 2009 | 51 | 2009 |
| QSAR using evolved neural networks for the inhibition of mutant PfDHFR by pyrimethamine derivatives D Hecht, M Cheung, GB Fogel Biosystems 92 (1), 10-15, 2008 | 44 | 2008 |
| A Novel In Silico Approach to Drug Discovery via Computational Intelligence D Hecht, GB Fogel Journal of chemical information and modeling 49 (4), 1105-1121, 2009 | 39 | 2009 |
| Defining Hydrophobicity: Probing the Structure of Solute-Induced Hydration Shells by Fourier Transform Infrared Spectroscopy D Hecht, L Tadesse, L Walters Journal of the American Chemical Society 114, 4336-4339, 1992 | 38 | 1992 |
| Applications of machine learning and computational intelligence to drug discovery and development D Hecht Drug Development Research 72 (1), 53-65, 2011 | 31 | 2011 |
| In silico screening against wild-type and mutant Plasmodium falciparum dihydrofolate reductase GB Fogel, M Cheung, E Pittman, D Hecht Journal of Molecular Graphics and Modelling 26 (7), 1145-1152, 2008 | 29 | 2008 |
| Modeling the inhibition of quadruple mutant Plasmodium falciparum dihydrofolate reductase by pyrimethamine derivatives GB Fogel, M Cheung, E Pittman, D Hecht Journal of Computer-Aided Molecular Design 22, 29-38, 2008 | 26 | 2008 |
| High-throughput ligand screening via preclustering and evolved neural networks D Hecht, G Fogel IEEE/ACM Transactions on Computational Biology and Bioinformatics 4 (3), 476-484, 2007 | 23 | 2007 |
| Structural-based analysis of dihydrofolate reductase evolution D Hecht, J Tran, GB Fogel Molecular phylogenetics and evolution 61 (1), 212-230, 2011 | 19 | 2011 |
| Computational intelligence methods for ADMET prediction D Hecht, GB Fogel Front Drug Des Discov 4 (27), 351-377, 2009 | 18 | 2009 |
| On the relationship between GC content and the number of predicted microRNA binding sites by MicroInspector N Davis, N Biddlecom, D Hecht, GB Fogel Computational Biology and Chemistry 32 (3), 222-226, 2008 | 15 | 2008 |
| Activity of selected nucleoside analogue protides against zika virus in human neural stem cells JA Bernatchez, M Coste, S Beck, GA Wells, LA Luna, AE Clark, Z Zhu, ... Viruses 11 (4), 365, 2019 | 13 | 2019 |
| Using SCDL for integrating tools and data for complex biomedical applications S Wang, RM Hu, HCW Hsiao, DA Hecht, KL Ng, RM Chen, PCY Sheu, ... International Journal of Semantic Computing 2 (02), 291-308, 2008 | 13 | 2008 |
| Modeling the structural origins of drug resistance to isoniazid via key mutations in Mycobacterium tuberculosis catalase-peroxidase, KatG MW Marney, RP Metzger, D Hecht, F Valafar Tuberculosis 108, 155-162, 2018 | 12 | 2018 |
| Modeling the evolution of drug resistance in malaria D Hecht, GB Fogel Journal of computer-aided molecular design 26, 1343-1353, 2012 | 12 | 2012 |
| Docking scores and QSAR using evolved neural networks for the pan-inhibition of wild-type and mutant PfDHFR by cycloguanil derivatives D Hecht, M Cheung, GB Fogel 2009 IEEE Congress on Evolutionary Computation, 262-269, 2009 | 10 | 2009 |
