| Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro I Malet, O Delelis, MA Valantin, B Montes, C Soulie, M Wirden, ... Antimicrobial agents and chemotherapy 52 (4), 1351-1358, 2008 | 346 | 2008 |
| Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells K Mekouar, JF Mouscadet, D Desmaële, F Subra, H Leh, D Savouré, ... Journal of medicinal chemistry 41 (15), 2846-2857, 1998 | 336 | 1998 |
| Integrase and integration: biochemical activities of HIV-1 integrase O Delelis, K Carayon, A Saïb, E Deprez, JF Mouscadet Retrovirology 5, 1-13, 2008 | 321 | 2008 |
| Synthesis and biological evaluation of substituted quinolines: potential treatment of protozoal and retroviral co-infections MA Fakhfakh, A Fournet, E Prina, JF Mouscadet, X Franck, ... Bioorganic & medicinal chemistry 11 (23), 5013-5023, 2003 | 246 | 2003 |
| Structure− activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture F Zouhiri, JF Mouscadet, K Mekouar, D Desmaële, D Savouré, H Leh, ... Journal of medicinal chemistry 43 (8), 1533-1540, 2000 | 218 | 2000 |
| Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection C Séror, MT Melki, F Subra, SQ Raza, M Bras, H Saïdi, R Nardacci, ... Journal of Experimental Medicine 208 (9), 1823-1834, 2011 | 206 | 2011 |
| Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity E Guiot, K Carayon, O Delelis, F Simon, P Tauc, E Zubin, M Gottikh, ... Journal of Biological Chemistry 281 (32), 22707-22719, 2006 | 192 | 2006 |
| Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy E Deprez, P Tauc, H Leh, JF Mouscadet, C Auclair, JC Brochon Biochemistry 39 (31), 9275-9284, 2000 | 172 | 2000 |
| The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation O Delelis, I Malet, L Na, L Tchertanov, V Calvez, AG Marcelin, F Subra, ... Nucleic Acids Research 37 (4), 1193-1201, 2009 | 164 | 2009 |
| Determinants of Mg2+-dependent activities of recombinant human immunodeficiency virus type 1 integrase H Leh, P Brodin, J Bischerour, E Deprez, P Tauc, JC Brochon, E LeCam, ... Biochemistry 39 (31), 9285-9294, 2000 | 162 | 2000 |
| Human immunodeficiency virus type 1 nucleocapsid protein specifically stimulates Mg2+-dependent DNA integration in vitro S Carteau, SC Batson, L Poljak, JF Mouscadet, H de Rocquigny, JL Darlix, ... Journal of virology 71 (8), 6225-6229, 1997 | 160 | 1997 |
| Design, Synthesis, and Biological Evaluation of a Series of 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as Dual Inhibitors of Human Immunodeficiency Virus Type 1 … M Billamboz, F Bailly, ML Barreca, L De Luca, JF Mouscadet, C Calmels, ... Journal of medicinal chemistry 51 (24), 7717-7730, 2008 | 149 | 2008 |
| Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity C Bénard, F Zouhiri, M Normand-Bayle, M Danet, D Desmaële, H Leh, ... Bioorganic & medicinal chemistry letters 14 (10), 2473-2476, 2004 | 143 | 2004 |
| Use of the Kohonen neural network for rapid screening of ex vivo anti-HIV activity of styrylquinolines J Polanski, F Zouhiri, L Jeanson, D Desmaële, J d'Angelo, JF Mouscadet, ... Journal of medicinal chemistry 45 (21), 4647-4654, 2002 | 138 | 2002 |
| HIV-1 replication inhibitors of the styrylquinoline class: Introduction of an additional carboxyl group at the C-5 position of the quinoline F Zouhiri, M Danet, C Bénard, M Normand-Bayle, JF Mouscadet, H Leh, ... Tetrahedron Letters 46 (13), 2201-2205, 2005 | 124 | 2005 |
| Structural basis for HIV‐1 DNA integration in the human genome, role of the LEDGF/P75 cofactor F Michel, C Crucifix, F Granger, S Eiler, JF Mouscadet, S Korolev, ... The EMBO journal 28 (7), 980-991, 2009 | 120 | 2009 |
| Mechanism of HIV-1 integrase inhibition by styrylquinoline derivatives in vitro E Deprez, S Barbe, M Kolaski, H Leh, F Zouhiri, C Auclair, JC Brochon, ... Molecular pharmacology 65 (1), 85-98, 2004 | 117 | 2004 |
| Styrylquinolines, integrase inhibitors acting prior to integration: a new mechanism of action for anti-integrase agents S Bonnenfant, CM Thomas, C Vita, F Subra, E Deprez, F Zouhiri, ... Journal of virology 78 (11), 5728-5736, 2004 | 115 | 2004 |
| DNA binding induces dissociation of the multimeric form of HIV-1 integrase: a time-resolved fluorescence anisotropy study E Deprez, P Tauc, H Leh, JF Mouscadet, C Auclair, ME Hawkins, ... Proceedings of the National Academy of Sciences 98 (18), 10090-10095, 2001 | 115 | 2001 |
| HIV-1 integrase inhibition of biscoumarin analogues CX Su, JF Mouscadet, CC Chiang, HJ Tsai, LY Hsu Chemical and pharmaceutical bulletin 54 (5), 682-686, 2006 | 113 | 2006 |
Christian AuclairProfesseur de biologie cellulaire et pharmacologie, Ecole Normale supérieure de Cachan, Faculté deVerified email at ens-cachan.fr
