| RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR) D Jiang, B Xiao, D Yang, R Wang, P Choi, L Zhang, H Cheng, SRW Chen Proceedings of the National Academy of Sciences 101 (35), 13062-13067, 2004 | 536 | 2004 |
| Inherited Dysfunction of Sarcoplasmic Reticulum Ca2+ Handling and Arrhythmogenesis SG Priori, SRW Chen Circulation research 108 (7), 871-883, 2011 | 488 | 2011 |
| Dantrolene inhibition of ryanodine receptor Ca2+ release channels: molecular mechanism and isoform selectivity F Zhao, P Li, SRW Chen, CF Louis, BR Fruen Journal of Biological Chemistry 276 (17), 13810-13816, 2001 | 411 | 2001 |
| Enhanced Store Overload–Induced Ca2+ Release and Channel Sensitivity to Luminal Ca2+ Activation Are Common Defects of RyR2 Mutations Linked to … D Jiang, R Wang, B Xiao, H Kong, DJ Hunt, P Choi, L Zhang, SRW Chen Circulation research 97 (11), 1173-1181, 2005 | 410 | 2005 |
| Carvedilol and its new analogs suppress arrhythmogenic store overload–induced Ca2+ release Q Zhou, J Xiao, D Jiang, R Wang, K Vembaiyan, A Wang, CD Smith, C Xie, ... Nature medicine 17 (8), 1003-1009, 2011 | 286 | 2011 |
| Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2 W Peng, H Shen, J Wu, W Guo, X Pan, R Wang, SRW Chen, N Yan Science 354 (6310), aah5324, 2016 | 285 | 2016 |
| Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure B Xiao, MT Jiang, M Zhao, D Yang, C Sutherland, FA Lai, MP Walsh, ... Circulation research 96 (8), 847-855, 2005 | 261 | 2005 |
| Enhanced Basal Activity of a Cardiac Ca2+ Release Channel (Ryanodine Receptor) Mutant Associated With Ventricular Tachycardia and Sudden Death D Jiang, B Xiao, L Zhang, SRW Chen Circulation research 91 (3), 218-225, 2002 | 259 | 2002 |
| Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon β-adrenergic stimulation in normal … B Xiao, G Zhong, M Obayashi, D Yang, K Chen, MP Walsh, Y Shimoni, ... Biochemical Journal 396 (1), 7-16, 2006 | 235 | 2006 |
| Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor H Kong, PP Jones, A Koop, L Zhang, HJ Duff, SRW Chen Biochemical Journal 414 (3), 441-452, 2008 | 234 | 2008 |
| Molecular identification of the ryanodine receptor pore-forming segment M Zhao, P Li, X Li, L Zhang, RJ Winkfein, SRW Chen Journal of Biological Chemistry 274 (37), 25971-25974, 1999 | 229 | 1999 |
| Protein Kinase A Phosphorylation at Serine-2808 of the Cardiac Ca2+-Release Channel (Ryanodine Receptor) Does Not Dissociate 12.6-kDa FK506-Binding … B Xiao, C Sutherland, MP Walsh, SRW Chen Circulation research 94 (4), 487-495, 2004 | 213 | 2004 |
| The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias W Chen, R Wang, B Chen, X Zhong, H Kong, Y Bai, Q Zhou, C Xie, ... Nature medicine 20 (2), 184-192, 2014 | 208 | 2014 |
| Functional characterization of the recombinant type 3 Ca2+ release channel (ryanodine receptor) expressed in HEK293 cells SRW Chen, X Li, K Ebisawa, L Zhang Journal of Biological Chemistry 272 (39), 24234-24246, 1997 | 186 | 1997 |
| Red fluorescent genetically encoded Ca2+ indicators for use in mitochondria and endoplasmic reticulum J Wu, DL Prole, Y Shen, Z Lin, A Gnanasekaran, Y Liu, L Chen, H Zhou, ... Biochemical Journal 464 (1), 13-22, 2014 | 160 | 2014 |
| Loss of luminal Ca2+ activation in the cardiac ryanodine receptor is associated with ventricular fibrillation and sudden death D Jiang, W Chen, R Wang, L Zhang, SRW Chen Proceedings of the National Academy of Sciences 104 (46), 18309-18314, 2007 | 157 | 2007 |
| Molecular Basis of Ca2+ Activation of the Mouse Cardiac Ca2+ Release Channel (Ryanodine Receptor) P Li, SRW Chen The Journal of general physiology 118 (1), 33-44, 2001 | 155 | 2001 |
| Molecular identification of the ryanodine receptor Ca2+ sensor SRW Chen, K Ebisawa, X Li, L Zhang Journal of Biological Chemistry 273 (24), 14675-14678, 1998 | 152 | 1998 |
| Divergent functional properties of ryanodine receptor types 1 and 3 expressed in a myogenic cell line JD Fessenden, Y Wang, RA Moore, SRW Chen, PD Allen, IN Pessah Biophysical Journal 79 (5), 2509-2525, 2000 | 144 | 2000 |
| Modulation of cardiac ryanodine receptor 2 by calmodulin D Gong, X Chi, J Wei, G Zhou, G Huang, L Zhang, R Wang, J Lei, ... Nature 572 (7769), 347-351, 2019 | 141 | 2019 |
