| Accurate prediction of protein structures and interactions using a three-track neural network M Baek, F DiMaio, I Anishchenko, J Dauparas, S Ovchinnikov, GR Lee, ... Science 373 (6557), 871-876, 2021 | 3350 | 2021 |
| Ras binder induces a modified switch-II pocket in GTP and GDP states DR Gentile, MK Rathinaswamy, ML Jenkins, SM Moss, BD Siempelkamp, ... Cell chemical biology 24 (12), 1455-1466. e14, 2017 | 92 | 2017 |
| Conformational sampling of membranes by Akt controls its activation and inactivation I Lučić, MK Rathinaswamy, L Truebestein, DJ Hamelin, JE Burke, ... Proceedings of the National Academy of Sciences 115 (17), E3940-E3949, 2018 | 83 | 2018 |
| Class I phosphoinositide 3-kinase (PI3K) regulatory subunits and their roles in signaling and disease MK Rathinaswamy, JE Burke Advances in Biological Regulation 75, 100657, 2020 | 74 | 2020 |
| Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas BD Siempelkamp, MK Rathinaswamy, ML Jenkins, JE Burke Journal of Biological Chemistry 292 (29), 12256-12266, 2017 | 68 | 2017 |
| Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation MK Rathinaswamy, U Dalwadi, KD Fleming, C Adams, JTB Stariha, ... Science Advances 7 (35), eabj4282, 2021 | 25 | 2021 |
| Disease related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors MK Rathinaswamy, Z Gaieb, KD Fleming, C Borsari, NJ Harris, BJ Moeller, ... Elife 10, e64691, 2021 | 25 | 2021 |
| Neolymphostin A is a covalent phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitor that employs an unusual electrophilic vinylogous ester G Castro-Falcón, GS Seiler, O Demir, MK Rathinaswamy, D Hamelin, ... Journal of medicinal chemistry 61 (23), 10463-10472, 2018 | 21 | 2018 |
| Defining how oncogenic and developmental mutations of PIK3R1 alter the regulation of class IA phosphoinositide 3-kinases GL Dornan, JTB Stariha, MK Rathinaswamy, CJ Powell, MJ Boulanger, ... Structure 28 (2), 145-156. e5, 2020 | 15 | 2020 |
| Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus ML Jenkins, H Ranga-Prasad, MAH Parson, NJ Harris, MK Rathinaswamy, ... Nature Communications 14 (1), 181, 2023 | 12 | 2023 |
| HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases MK Rathinaswamy, KD Fleming, U Dalwadi, E Pardon, NJ Harris, CK Yip, ... Structure 29 (12), 1371-1381. e6, 2021 | 9 | 2021 |
| Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs MK Rathinaswamy, ML Jenkins, BR Duewell, X Zhang, NJ Harris, ... Cell Reports 42 (3), 2023 | 6 | 2023 |
| Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain NJ Harris, ML Jenkins, SE Nam, MK Rathinaswamy, MAH Parson, ... Elife 12, RP88058, 2023 | 1 | 2023 |
| Molecular basis for the regulation of phosphoinositide 3-kinase γ (PI3Kγ) MK Rathinaswamy | | 2021 |
