An updated evolutionary classification of CRISPR–Cas systems KS Makarova, YI Wolf, OS Alkhnbashi, F Costa, SA Shah, SJ Saunders, ... Nature reviews microbiology 13 (11), 722-736, 2015 | 2835 | 2015 |
GraphProt: modeling binding preferences of RNA-binding proteins D Maticzka, SJ Lange, F Costa, R Backofen Genome biology 15, 1-18, 2014 | 266 | 2014 |
Global or local? Predicting secondary structure and accessibility in mRNAs SJ Lange, D Maticzka, M Möhl, JN Gagnon, CM Brown, R Backofen Nucleic acids research 40 (12), 5215-5226, 2012 | 161 | 2012 |
CRISPRmap: an automated classification of repeat conservation in prokaryotic adaptive immune systems SJ Lange, OS Alkhnbashi, D Rose, S Will, R Backofen Nucleic acids research 41 (17), 8034-8044, 2013 | 160 | 2013 |
CRISPR-Cas systems in the cyanobacterium Synechocystis sp. PCC6803 exhibit distinct processing pathways involving at least two Cas6 and a Cmr2 protein I Scholz, SJ Lange, S Hein, WR Hess, R Backofen PloS one 8 (2), e56470, 2013 | 139 | 2013 |
Partitioning biological data with transitivity clustering T Wittkop, D Emig, S Lange, S Rahmann, M Albrecht, JH Morris, S Böcker, ... Nature methods 7 (6), 419-420, 2010 | 131 | 2010 |
Characterizing leader sequences of CRISPR loci OS Alkhnbashi, SA Shah, RA Garrett, SJ Saunders, F Costa, R Backofen Bioinformatics 32 (17), i576-i585, 2016 | 100 | 2016 |
A complex of Cas proteins 5, 6, and 7 is required for the biogenesis and stability of clustered regularly interspaced short palindromic repeats (crispr)-derived rnas (crrnas … J Brendel, B Stoll, SJ Lange, K Sharma, C Lenz, AE Stachler, LK Maier, ... Journal of Biological Chemistry 289 (10), 7164-7177, 2014 | 87 | 2014 |
CRISPRstrand: predicting repeat orientations to determine the crRNA-encoding strand at CRISPR loci OS Alkhnbashi, F Costa, SA Shah, RA Garrett, SJ Saunders, R Backofen Bioinformatics 30 (17), i489-i496, 2014 | 69 | 2014 |
Essential requirements for the detection and degradation of invaders by the Haloferax volcanii CRISPR/Cas system IB LK Maier, SJ Lange, B Stoll, KA Haas, SM Fischer, E Fischer, ... RNA biology 10 (5), 865-874, 2013 | 67 | 2013 |
Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells M Hölzer, V Krähling, F Amman, E Barth, SH Bernhart, VAO Carmelo, ... Scientific reports 6 (1), 34589, 2016 | 63 | 2016 |
Two CRISPR-Cas systems in Methanosarcina mazei strain Gö1 display common processing features despite belonging to different types I and III L Nickel, K Weidenbach, D Jäger, R Backofen, SJ Lange, N Heidrich, ... RNA biology 10 (5), 779-791, 2013 | 60 | 2013 |
Critical review of European health-economic guidelines for the health technology assessment of medical devices M Blüher, SJ Saunders, V Mittard, R Torrejon Torres, JA Davis, ... Frontiers in medicine 6, 278, 2019 | 59 | 2019 |
Qupe—a rich internet application to take a step forward in the analysis of mass spectrometry-based quantitative proteomics experiments SP Albaum, H Neuweger, B Fränzel, S Lange, D Mertens, C Trötschel, ... Bioinformatics 25 (23), 3128-3134, 2009 | 40 | 2009 |
Structural constraints and enzymatic promiscuity in the Cas6-dependent generation of crRNAs V Reimann, OS Alkhnbashi, SJ Saunders, I Scholz, S Hein, R Backofen, ... Nucleic Acids Research 45 (2), 915-925, 2017 | 33 | 2017 |
An active immune defense with a minimal CRISPR (clustered regularly interspaced short palindromic repeats) RNA and without the Cas6 protein LK Maier, AE Stachler, SJ Saunders, R Backofen, A Marchfelder Journal of Biological Chemistry 290 (7), 4192-4201, 2015 | 32 | 2015 |
IMS2–An integrated medical software system for early lung cancer detection using ion mobility spectrometry data of human breath J Baumbach, A Bunkowski, S Lange, T Oberwahrenbrock, N Kleinbölting, ... Journal of Integrative Bioinformatics 4 (3), 186-197, 2007 | 31 | 2007 |
IMS2–An integrated medical software system for early lung cancer detection using ion mobility spectrometry data of human breath J Baumbach, A Bunkowski, S Lange, T Oberwahrenbrock, N Kleinbölting, ... Journal of Integrative Bioinformatics 4 (3), 186-197, 2007 | 31 | 2007 |
Comparative analysis of Cas6b processing and CRISPR RNA stability H Richter, SJ Lange, R Backofen, L Randau RNA biology 10 (5), 700-707, 2013 | 26 | 2013 |
Combinatorial ensemble miRNA target prediction of co-regulation networks with non-prediction data JA Davis, SJ Saunders, M Mann, R Backofen Nucleic acids research 45 (15), 8745-8757, 2017 | 22 | 2017 |