| Structural basis of substrate specificity in the serine proteases JJ Perona, CS Craik Protein Science 4 (3), 337-360, 1995 | 934 | 1995 |
| Lysosomal cysteine proteases: more than scavengers B Turk, D Turk, V Turk Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular …, 2000 | 929 | 2000 |
| Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries JL Harris, BJ Backes, F Leonetti, S Mahrus, JA Ellman, CS Craik Proceedings of the National Academy of Sciences 97 (14), 7754-7759, 2000 | 530 | 2000 |
| Global landscape of HIV–human protein complexes S Jaeger, P Cimermancic, N Gulbahce, JR Johnson, KE McGovern, ... Nature 481 (7381), 365, 2012 | 507 | 2012 |
| Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates T Takeuchi, JL Harris, W Huang, KW Yan, SR Coughlin, CS Craik Journal of Biological Chemistry 275 (34), 26333-26342, 2000 | 481 | 2000 |
| Redesigning trypsin: alteration of substrate specificity CS Craik, C Largman, T Fletcher, S Roczniak, PJ Barr, R Fletterick, ... Science 228 (4697), 291-297, 1985 | 428 | 1985 |
| Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin-and antibody-stimulated glucose uptake and receptor kinase activity Y Ebina, E Araki, M Taira, F Shimada, M Mori, CS Craik, K Siddle, ... Proceedings of the National Academy of Sciences 84 (3), 704-708, 1987 | 426 | 1987 |
| Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold JJ Perona, CS Craik Journal of Biological Chemistry 272 (48), 29987-29990, 1997 | 348 | 1997 |
| The catalytic role of the active site aspartic acid in serine proteases CS Craik, S Roczniak, C Largman, WJ Rutter Science 237 (4817), 909-913, 1987 | 346 | 1987 |
| Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities Y Choe, F Leonetti, DC Greenbaum, F Lecaille, M Bogyo, D Brömme, ... Journal of Biological Chemistry 281 (18), 12824-12832, 2006 | 336 | 2006 |
| Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease RL DesJarlais, GL Seibel, ID Kuntz, PS Furth, JC Alvarez, ... Proceedings of the National Academy of Sciences 87 (17), 6644-6648, 1990 | 321 | 1990 |
| The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi. AE Eakin, AA Mills, G Harth, JH McKerrow, CS Craik Journal of Biological Chemistry 267 (11), 7411-7420, 1992 | 315 | 1992 |
| Cathepsin G activates protease-activated receptor-4 in human platelets GR Sambrano, W Huang, T Faruqi, S Mahrus, C Craik, SR Coughlin Journal of Biological Chemistry 275 (10), 6819-6823, 2000 | 311 | 2000 |
| Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection S Jäger, DY Kim, JF Hultquist, K Shindo, RS LaRue, E Kwon, M Li, ... Nature 481 (7381), 371, 2012 | 301 | 2012 |
| Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and … T Takeuchi, MA Shuman, CS Craik Proceedings of the National Academy of Sciences 96 (20), 11054-11061, 1999 | 287 | 1999 |
| The crystal structure of cruzain: a therapeutic target for Chagas' disease ME McGrath, AE Eakin, JC Engel, JH McKerrow, CS Craik, RJ Fletterick Journal of molecular biology 247 (2), 251-259, 1995 | 278 | 1995 |
| Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin BJ Backes, JL Harris, F Leonetti, CS Craik, JA Ellman Nature biotechnology 18 (2), 187, 2000 | 271 | 2000 |
| Splice junctions: association with variation in protein structure CS Craik, WJ Rutter, R Fletterick Science 220 (4602), 1125-1129, 1983 | 265 | 1983 |
| The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis S Sprang, T Standing, RJ Fletterick, RM Stroud, J Finer-Moore, NH Xuong, ... Science 237 (4817), 905-909, 1987 | 243 | 1987 |
| Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family. P Vanderslice, SM Ballinger, EK Tam, SM Goldstein, CS Craik, ... Proceedings of the National Academy of Sciences 87 (10), 3811-3815, 1990 | 242 | 1990 |