Robert A. Saxton
Robert A. Saxton
Verified email at stanford.edu
Title
Cited by
Cited by
Year
mTOR signaling in growth, metabolism, and disease
RA Saxton, DM Sabatini
Cell 168 (6), 960-976, 2017
43652017
Sestrin2 is a leucine sensor for the mTORC1 pathway
RL Wolfson, L Chantranupong, RA Saxton, K Shen, SM Scaria, JR Cantor, ...
Science 351 (6268), 43-48, 2016
7642016
The CASTOR proteins are arginine sensors for the mTORC1 pathway
L Chantranupong, SM Scaria, RA Saxton, MP Gygi, K Shen, GA Wyant, ...
Cell 165 (1), 153-164, 2016
5052016
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
L Chantranupong, RL Wolfson, JM Orozco, RA Saxton, SM Scaria, ...
Cell reports 9 (1), 1-8, 2014
3412014
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
RA Saxton, KE Knockenhauer, RL Wolfson, L Chantranupong, ME Pacold, ...
Science 351 (6268), 53-58, 2016
3072016
SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway
X Gu, JM Orozco, RA Saxton, KJ Condon, GY Liu, PA Krawczyk, ...
Science 358 (6364), 813-818, 2017
2692017
Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
RA Saxton, L Chantranupong, KE Knockenhauer, TU Schwartz, ...
Nature 536 (7615), 229-233, 2016
2002016
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
K Mohan, G Ueda, AR Kim, KM Jude, JA Fallas, Y Guo, M Hafer, Y Miao, ...
Science 364 (6442), 2019
442019
Dimerization quality control ensures neuronal development and survival
EL Mena, RAS Kjolby, RA Saxton, A Werner, BG Lew, JM Boyle, ...
Science 362 (6411), 2018
392018
The apo-structure of the leucine sensor Sestrin2 is still elusive
RA Saxton, KE Knockenhauer, TU Schwartz, DM Sabatini
Science signaling 9 (446), ra92-ra92, 2016
222016
Structure-based decoupling of the pro-and anti-inflammatory functions of interleukin-10
RA Saxton, N Tsutsumi, LL Su, GC Abhiraman, K Mohan, LT Henneberg, ...
Science 371 (6535), 2021
102021
The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design
RA Saxton, LT Henneberg, M Calafiore, L Su, KM Jude, AM Hanash, ...
Immunity 54 (4), 660-672. e9, 2021
62021
METHODS OF IDENTIFYING MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USE OF SAME TO MODULATE mTORC1
DM Sabatini, L Chantranupong, RL Wolfson, J Orozco, RA Saxton, ...
22016
Cryo‐EM structure of the IL‐10 receptor complex provides a blueprint for ligand engineering
RA Saxton, KC Garcia
The FEBS Journal, 2021
2021
Methods of identifying modulators of CASTOR1-GATOR2 interaction and use of same to modulate mTORC1
DM Sabatini, L Chantranupong, RA Saxton, SP Gygi, MP Gygi
US Patent 11,092,608, 2021
2021
Mechanisms of amino acid sensing by the mTORC1 pathway
RA Saxton
Massachusetts Institute of Technology, 2018
2018
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