Bruno David Fonseca
Bruno David Fonseca
NanoVation Therapeutics
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mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs
RJO Dowling, I Topisirovic, T Alain, M Bidinosti, BD Fonseca, ...
Science 328 (5982), 1172-1176, 2010
Dissecting the role of mTOR: lessons from mTOR inhibitors
RJO Dowling, I Topisirovic, BD Fonseca, N Sonenberg
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1804 (3), 433-439, 2010
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling
AD Balgi, BD Fonseca, E Donohue, TCF Tsang, P Lajoie, CG Proud, ...
PloS one 4 (9), e7124, 2009
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
BD Fonseca, EM Smith, VHY Lee, C MacKintosh, CG Proud
Journal of Biological Chemistry 282 (34), 24514-24524, 2007
La-related protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1)
BD Fonseca, C Zakaria, JJ Jia, TE Graber, Y Svitkin, S Tahmasebi, ...
Journal of Biological Chemistry 290 (26), 15996-16020, 2015
Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling
X Wang, BD Fonseca, H Tang, R Liu, A Elia, MJ Clemens, UA Bommer, ...
Journal of Biological Chemistry 283 (45), 30482-30492, 2008
Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1
J Averous, BD Fonseca, CG Proud
Oncogene 27 (8), 1106-1113, 2008
A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development
M Morita, LW Ler, MR Fabian, N Siddiqui, M Mullin, VC Henderson, ...
Molecular and cellular biology, 2012
La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs
RM Lahr, BD Fonseca, GE Ciotti, HA Al-Ashtal, JJ Jia, MR Niklaus, ...
Elife 6, e24146, 2017
eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies
T Alain, M Morita, BD Fonseca, A Yanagiya, N Siddiqui, M Bhat, D Zammit, ...
Cancer research 72 (24), 6468-6476, 2012
Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling
BD Fonseca, GH Diering, MA Bidinosti, K Dalal, T Alain, AD Balgi, ...
Journal of Biological Chemistry 287 (21), 17530-17545, 2012
The ever-evolving role of mTOR in translation
BD Fonseca, EM Smith, N Yelle, T Alain, M Bushell, A Pause
Seminars in cell & developmental biology 36, 102-112, 2014
Regulation of mTORC1 signaling by pH
AD Balgi, GH Diering, E Donohue, KKY Lam, BD Fonseca, C Zimmerman, ...
PloS one 6 (6), e21549, 2011
Calpain activity is generally elevated during transformation but has oncogene-specific biological functions
NO Carragher, BD Fonseca, MC Frame
Neoplasia 6 (1), 53-73, 2004
S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3
F Wang, T Alain, KJ Szretter, K Stephenson, JG Pol, MJ Atherton, ...
Nature immunology 17 (5), 514-522, 2016
LARP1 on TOP of ribosome production
BD Fonseca, RM Lahr, CK Damgaard, T Alain, AJ Berman
Wiley Interdisciplinary Reviews: RNA 9 (5), e1480, 2018
mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1
JJ Jia, RM Lahr, MT Solgaard, BJ Moraes, R Pointet, AD Yang, G Celucci, ...
Nucleic acids research 49 (6), 3461-3489, 2021
Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3
Y Tsukumo, T Alain, BD Fonseca, R Nadon, N Sonenberg
Nature communications 7 (1), 11776, 2016
Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated …
BD Fonseca, T Alain, LK Finestone, BPH Huang, M Rolfe, T Jiang, Z Yao, ...
Journal of Biological Chemistry 286 (31), 27111-27122, 2011
Analysis of the regulatory motifs in eukaryotic initiation factor 4E‐binding protein 1
VHY Lee, T Healy, BD Fonseca, A Hayashi, CG Proud
The FEBS journal 275 (9), 2185-2199, 2008
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