Bruno David Fonseca

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Tommy AlainChildren's Hospital of Eastern Ontario Research Institute and University of OttawaAdresse e-mail validée de arc.cheo.ca
Christopher ProudDistinguished Fellow, SAHMRIAdresse e-mail validée de sahmri.com
Nahum SonenbergGilman Cheney Professor in BiochemistryAdresse e-mail validée de mcgill.ca
ivan topisirovicProfessor, McGill, Lady Davis InstituteAdresse e-mail validée de mcgill.ca
Ewan SmithPostdoctoral researcher, Beatson InstituteAdresse e-mail validée de beatson.gla.ac.uk
Andrea J. BermanAssociate Professor of Biological Sciences, University of PittsburghAdresse e-mail validée de pitt.edu
Roni LahrUniversity of PittsburghAdresse e-mail validée de pitt.edu
Ola LarssonAssociate professor, Karolinska InstitutetAdresse e-mail validée de ki.se
Christian Kroun DamgaardAssociate Professor, Department of Molecular Biology and Genetics, Aarhus UniversityAdresse e-mail validée de mbg.au.dk
Tyson GraberChildren's Hospital of Eastern Ontario Research InstituteAdresse e-mail validée de arc.cheo.ca
Masahiro MoritaTenure-Track Assistant Professor (principal investigator), Department of Molecular Medicine andAdresse e-mail validée de uthscsa.edu
Michel RobergeUniversity of British ColumbiaAdresse e-mail validée de mail.ubc.ca
Hoàng DũngPostdoctoral Fellow, Children's Hospital of Eastern Ontario Research InstituteAdresse e-mail validée de uottawa.ca
Greco HernándezP.I. Instituto Nacional de CancerologíaAdresse e-mail validée de incan.edu.mx
Akiko YanagiyaAdresse e-mail validée de oist.jp
Graham H. DieringAssistant professor Cell Biology and Physiology, University of North CarolinaAdresse e-mail validée de med.unc.edu
xuemin wangSAHMRIAdresse e-mail validée de sahmri.com
Patrick LajoieAssociate Professor, The University of Western OntarioAdresse e-mail validée de uwo.ca
Carol MacKintoshProfessor of Molecular Signalling, University of Dundee, ScotlandAdresse e-mail validée de dundee.ac.uk
Edna Patricia Matta-CamachoHealth CanadaAdresse e-mail validée de mail.mcgill.ca

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Bruno David Fonseca

NanoVation Therapeutics

Adresse e-mail validée de primergen.group

Drug Discovery mTOR LARP1 Rapamycin Niclosamide


Titre Trier par citations Trier par année Trier par titre	Citée par Citée par	Année
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs RJO Dowling, I Topisirovic, T Alain, M Bidinosti, BD Fonseca, ... Science 328 (5982), 1172-1176, 2010	824	2010
Dissecting the role of mTOR: lessons from mTOR inhibitors RJO Dowling, I Topisirovic, BD Fonseca, N Sonenberg Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1804 (3), 433-439, 2010	564	2010
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling AD Balgi, BD Fonseca, E Donohue, TCF Tsang, P Lajoie, CG Proud, ... PloS one 4 (9), e7124, 2009	371	2009
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex BD Fonseca, EM Smith, VHY Lee, C MacKintosh, CG Proud Journal of Biological Chemistry 282 (34), 24514-24524, 2007	295	2007
La-related protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1) BD Fonseca, C Zakaria, JJ Jia, TE Graber, Y Svitkin, S Tahmasebi, ... Journal of Biological Chemistry 290 (26), 15996-16020, 2015	261	2015
Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling X Wang, BD Fonseca, H Tang, R Liu, A Elia, MJ Clemens, UA Bommer, ... Journal of Biological Chemistry 283 (45), 30482-30492, 2008	238	2008
Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1 J Averous, BD Fonseca, CG Proud Oncogene 27 (8), 1106-1113, 2008	226	2008
A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development M Morita, LW Ler, MR Fabian, N Siddiqui, M Mullin, VC Henderson, ... Molecular and cellular biology 32 (17), 3585-3593, 2012	216	2012
La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs RM Lahr, BD Fonseca, GE Ciotti, HA Al-Ashtal, JJ Jia, MR Niklaus, ... Elife 6, e24146, 2017	189	2017
eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies T Alain, M Morita, BD Fonseca, A Yanagiya, N Siddiqui, M Bhat, D Zammit, ... Cancer research 72 (24), 6468-6476, 2012	185	2012
Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling BD Fonseca, GH Diering, MA Bidinosti, K Dalal, T Alain, AD Balgi, ... Journal of Biological Chemistry 287 (21), 17530-17545, 2012	161	2012
The ever-evolving role of mTOR in translation BD Fonseca, EM Smith, N Yelle, T Alain, M Bushell, A Pause Seminars in cell & developmental biology 36, 102-112, 2014	126	2014
Regulation of mTORC1 signaling by pH AD Balgi, GH Diering, E Donohue, KKY Lam, BD Fonseca, C Zimmerman, ... PloS one 6 (6), e21549, 2011	124	2011
Calpain activity is generally elevated during transformation but has oncogene-specific biological functions NO Carragher, BD Fonseca, MC Frame Neoplasia 6 (1), 53-73, 2004	90	2004
S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3 F Wang, T Alain, KJ Szretter, K Stephenson, JG Pol, MJ Atherton, ... Nature immunology 17 (5), 514-522, 2016	86	2016
LARP1 on TOP of ribosome production BD Fonseca, RM Lahr, CK Damgaard, T Alain, AJ Berman Wiley Interdisciplinary Reviews: RNA 9 (5), e1480, 2018	76	2018
mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1 JJ Jia, RM Lahr, MT Solgaard, BJ Moraes, R Pointet, AD Yang, G Celucci, ... Nucleic acids research 49 (6), 3461-3489, 2021	61	2021
Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3 Y Tsukumo, T Alain, BD Fonseca, R Nadon, N Sonenberg Nature communications 7 (1), 11776, 2016	55	2016
Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated … BD Fonseca, T Alain, LK Finestone, BPH Huang, M Rolfe, T Jiang, Z Yao, ... Journal of Biological Chemistry 286 (31), 27111-27122, 2011	51	2011
Analysis of the regulatory motifs in eukaryotic initiation factor 4E‐binding protein 1 VHY Lee, T Healy, BD Fonseca, A Hayashi, CG Proud The FEBS journal 275 (9), 2185-2199, 2008	50	2008

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