Gianni M. Castiglione

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Belinda S W ChangProfessor of Ecology and Evolutionary Biology & Cell and Systems Biology, University of TorontoVerified email at utoronto.ca
Elia DuhJohns Hopkins University School of MedicineVerified email at jhmi.edu
Frances E. HauserNSERC Postdoctoral Fellow, University of Toronto ScarboroughVerified email at utoronto.ca
Ryan K SchottDepartment of Biology, York UniversityVerified email at yorku.ca
Lingli ZhouPostdoctoral Research Fellow, Johns Hopkins UniversityVerified email at jhmi.edu
Alexander Van NynattenPostdoctoral fellow, Department of Biology, University of VictoriaVerified email at mail.utoronto.ca
charles eberhartProfessor of Pathology, Ophthalmology and Oncology, Johns Hopkins University School of MedicineVerified email at jhmi.edu
James M. MorrowForensic Scientist, Ministry of the Solicitor General, Toronto, Ontario, CanadaVerified email at utoronto.ca
Nihar BhattacharyyaPost-doctoral fellow, University College LondonVerified email at mail.utoronto.ca
Sarah Z. DunganUniversity of TorontoVerified email at mail.utoronto.ca
Eduardo de Almeida GutierrezResearch associate, University of TorontoVerified email at mail.utoronto.ca
Hernán López-FernándezAssociate Professor and Associate Curator of Fishes, University of Michigan Museum of ZoologyVerified email at umich.edu
Nathan K. LujanAssociate Curator of Fishes, Royal Ontario Musuem; Assistant Professor, University of TorontoVerified email at rom.on.ca
Dinesh ChristendatProfessor of Cell and Systems Biology, University of TorontoVerified email at utoronto.ca

Gianni M. Castiglione

Assistant Professor, Vanderbilt University

Verified email at vanderbilt.edu

Vision Protein Structure Function Molecular Evolution


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ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection L Zhou, Z Xu, GM Castiglione, US Soiberman, CG Eberhart, EJ Duh The ocular surface 18 (4), 537-544, 2020	367	2020
Accelerated evolution and functional divergence of the dim light visual pigment accompanies cichlid colonization of Central America FE Hauser, KL Ilves, RK Schott, GM Castiglione, H López-Fernández, ... Molecular biology and evolution 34 (10), 2650-2664, 2017	52	2017
Evolution of nonspectral rhodopsin function at high altitudes GM Castiglione, FE Hauser, BS Liao, NK Lujan, A Van Nynatten, ... Proceedings of the National Academy of Sciences 114 (28), 7385-7390, 2017	35	2017
Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds GM Castiglione, Z Xu, L Zhou, EJ Duh Nature communications 11 (1), 2476, 2020	34	2020
Functional shifts in bat dim-light visual pigment are associated with differing echolocation abilities and reveal molecular adaptation to photic-limited environments EA Gutierrez, GM Castiglione, JM Morrow, RK Schott, LO Loureiro, ... Molecular Biology and Evolution 35 (10), 2422-2434, 2018	30	2018
Functional trade-offs and environmental variation shaped ancient trajectories in the evolution of dim-light vision GM Castiglione, BSW Chang Elife 7, e35957, 2018	26	2018
Convergent selection pressures drive the evolution of rhodopsin kinetics at high altitudes via nonparallel mechanisms GM Castiglione, RK Schott, FE Hauser, BSW Chang Evolution 72 (1), 170-186, 2018	25	2018
An experimental comparison of human and bovine rhodopsin provides insight into the molecular basis of retinal disease JM Morrow, GM Castiglione, SZ Dungan, PL Tang, N Bhattacharyya, ... FEBS letters 591 (12), 1720-1731, 2017	21	2017
Isolation and molecular characterization of the shikimate dehydrogenase domain from the Toxoplasma gondii AROM complex J Peek, G Castiglione, T Shi, D Christendat Molecular and Biochemical Parasitology 194 (1-2), 16-19, 2014	16	2014
Recreated ancestral opsin associated with marine to freshwater croaker invasion reveals kinetic and spectral adaptation A Van Nynatten, GM Castiglione, E de A. Gutierrez, NR Lovejoy, ... Molecular Biology and Evolution 38 (5), 2076-2087, 2021	14	2021
Evolutionary pathways to SARS-CoV-2 resistance are opened and closed by epistasis acting on ACE2 GM Castiglione, L Zhou, Z Xu, Z Neiman, CF Hung, EJ Duh PLoS biology 19 (12), e3001510, 2021	9	2021
In vivo characterization of emerging SARS-CoV-2 variant infectivity and human antibody escape potential B Lam, YJ Kung, J Lin, SH Tseng, YC Tsai, L He, G Castiglione, E Egbert, ... Cell reports 37 (3), 2021	7	2021
Comparative sequence analyses of rhodopsin and RPE65 reveal patterns of selective constraint across hereditary retinal disease mutations FE Hauser, RK Schott, GM Castiglione, A Van Nynatten, A Kosyakov, ... Visual Neuroscience 33, E002, 2016	7	2016
Convergent evolution of dim light vision in owls and deep-diving whales GM Castiglione, YLI Chiu, EA Gutierrez, A Van Nynatten, FE Hauser, ... Current Biology 33 (21), 4733-4740. e4, 2023	2	2023
Adaptation of Antarctic icefish vision to extreme environments GM Castiglione, FE Hauser, A Van Nynatten, BSW Chang Molecular Biology and Evolution 40 (4), msad030, 2023	2	2023

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