Alexandre ORTHWEIN
Alexandre ORTHWEIN
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A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice
C Escribano-Díaz, A Orthwein, A Fradet-Turcotte, M Xing, JTF Young, ...
Molecular cell 49 (5), 872-883, 2013
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark
A Fradet-Turcotte, MD Canny, C Escribano-Díaz, A Orthwein, CCY Leung, ...
Nature 499 (7456), 50-54, 2013
A mechanism for the suppression of homologous recombination in G1 cells
A Orthwein, SM Noordermeer, MD Wilson, S Landry, RI Enchev, ...
Nature 528 (7582), 422-426, 2015
Mitosis inhibits DNA double-strand break repair to guard against telomere fusions
A Orthwein, A Fradet-Turcotte, SM Noordermeer, MD Canny, CM Brun, ...
Science 344 (6180), 189-193, 2014
A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer
P Polak, J Kim, LZ Braunstein, R Karlic, NJ Haradhavala, G Tiao, ...
Nature genetics 49 (10), 1476, 2017
MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end resection
V Boersma, N Moatti, S Segura-Bayona, MH Peuscher, J Van der Torre, ...
Nature 521 (7553), 537-540, 2015
Active nuclear import and cytoplasmic retention of activation-induced deaminase
AM Patenaude, A Orthwein, Y Hu, VA Campo, B Kavli, A Buschiazzo, ...
Nature structural & molecular biology 16 (5), 517-527, 2009
Productive human immunodeficiency virus type 1 assembly takes place at the plasma membrane
A Finzi, A Orthwein, J Mercier, ÉA Cohen
Journal of virology 81 (14), 7476-7490, 2007
Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency
MD Canny, N Moatti, LCK Wan, A Fradet-Turcotte, D Krasner, ...
Nature biotechnology 36 (1), 95, 2018
Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90
A Orthwein, AM Patenaude, EB Affar, A Lamarre, JC Young, JM Di Noia
Journal of Experimental Medicine 207 (12), 2751-2765, 2010
HELB is a feedback inhibitor of DNA end resection
J Tkáč, G Xu, H Adhikary, JTF Young, D Gallo, C Escribano-Díaz, ...
Molecular cell 61 (3), 405-418, 2016
SHLD 2/FAM 35A co‐operates with REV 7 to coordinate DNA double‐strand break repair pathway choice
S Findlay, J Heath, VM Luo, A Malina, T Morin, Y Coulombe, B Djerir, Z Li, ...
The EMBO journal 37 (18), e100158, 2018
BRCA2 functions: from DNA repair to replication fork stabilization
A Fradet-Turcotte, J Sitz, D Grapton, A Orthwein
Endocr Relat Cancer 23 (10), T1-T17, 2016
Optimal functional levels of activation‐induced deaminase specifically require the Hsp40 DnaJa1
A Orthwein, A Zahn, SP Methot, D Godin, SG Conticello, K Terada, ...
The EMBO journal 31 (3), 679-691, 2012
Activation induced deaminase: how much and where?
A Orthwein, JM Di Noia
Seminars in immunology 24 (4), 246-254, 2012
Functionally null RAD51D missense mutation associates strongly with ovarian carcinoma
B Rivera, M Di Iorio, J Frankum, J Nadaf, S Fahiminiya, SL Arcand, ...
Cancer research 77 (16), 4517-4529, 2017
GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1
C Vadnais, R Chen, J Fraszczak, Z Yu, J Boulais, J Pinder, D Frank, ...
Nature communications 9 (1), 1-14, 2018
CRISPR/Cas9 gene editing: from basic mechanisms to improved strategies for enhanced genome engineering in vivo
J Salsman, JY Masson, A Orthwein, G Dellaire
Current gene therapy 17 (4), 263-274, 2017
HSP90 inhibitors decrease AID levels and activity in mice and in human cells
D Montamat‐Sicotte, LC Litzler, C Abreu, S Safavi, A Zahn, A Orthwein, ...
European journal of immunology 45 (8), 2365-2376, 2015
Mapping global and local coevolution across 600 species to identify novel homologous recombination repair genes
D Sherill-Rofe, D Rahat, S Findlay, A Mellul, I Guberman, M Braun, I Bloch, ...
Genome research 29 (3), 439-448, 2019
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