Mouse genome editing using the CRISPR/Cas system DW Harms, RM Quadros, D Seruggia, M Ohtsuka, G Takahashi, ... Current protocols in human genetics 83 (1), 15.7. 1-15.7. 27, 2014 | 173 | 2014 |
Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy M Di Pilato, EY Kim, BL Cadilha, JN Prüßmann, MN Nasrallah, ... Nature 570 (7759), 112-116, 2019 | 171 | 2019 |
MIR retrotransposon sequences provide insulators to the human genome J Wang, C Vicente-García, D Seruggia, E Moltó, A Fernandez-Miñán, ... Proceedings of the National Academy of Sciences 112 (32), E4428-E4437, 2015 | 123 | 2015 |
The new CRISPR-Cas system: RNA-guided genome engineering to efficiently produce any desired genetic alteration in animals D Seruggia, L Montoliu Transgenic Research, 2014 | 104 | 2014 |
BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells DN Debruyne, R Dries, S Sengupta, D Seruggia, Y Gao, B Sharma, ... Nature 572 (7771), 676-680, 2019 | 100 | 2019 |
Binary recombinase systems for high-resolution conditional mutagenesis M Hermann, P Stillhard, H Wildner, D Seruggia, V Kapp, ... Nucleic Acids Research 42 (6), 3894-3907, 2014 | 93 | 2014 |
Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis F Sher, M Hossain, D Seruggia, VAC Schoonenberg, Q Yao, P Cifani, ... Nature genetics 51 (7), 1149-1159, 2019 | 92 | 2019 |
Functional validation of mouse tyrosinase non-coding regulatory DNA elements by CRISPR-Cas9-mediated mutagenesis D Seruggia, A Fernández, M Cantero, P Pelczar, L Montoliu Nucleic Acids Research, gkv375, 2015 | 81 | 2015 |
Atomic force microscopy study of DNA conformation in the presence of drugs V Cassina, D Seruggia, GL Beretta, D Salerno, D Brogioli, S Manzini, ... European Biophysics Journal 40, 59-68, 2011 | 76 | 2011 |
Magnetic tweezers measurements of the nanomechanical properties of DNA in the presence of drugs D Salerno, D Brogioli, V Cassina, D Turchi, GL Beretta, D Seruggia, ... Nucleic acids research 38 (20), 7089-7099, 2010 | 70 | 2010 |
JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma E Manieri, C Folgueira, ME Rodríguez, L Leiva-Vega, L Esteban-Lafuente, ... Proceedings of the National Academy of Sciences 117 (28), 16492-16499, 2020 | 52 | 2020 |
The PEG13-DMR and brain-specific enhancers dictate imprinted expression within the 8q24 intellectual disability risk locus F Court, C Camprubi, CV Garcia, A Guillaumet-Adkins, A Sparago, ... Epigenetics & Chromatin 7, 1-13, 2014 | 42 | 2014 |
Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation L LeBlanc, BK Lee, AC Yu, M Kim, AV Kambhampati, SM Dupont, ... Elife 7, e40167, 2018 | 40 | 2018 |
TAF5L and TAF6L maintain self-renewal of embryonic stem cells via the MYC regulatory network D Seruggia, M Oti, P Tripathi, MC Canver, L LeBlanc, DC Di Giammartino, ... Molecular Cell 74 (6), 1148-1163. e7, 2019 | 38 | 2019 |
Enhancer dependence of cell-type–specific gene expression increases with developmental age W Cai, J Huang, Q Zhu, BE Li, D Seruggia, P Zhou, M Nguyen, Y Fujiwara, ... Proceedings of the National Academy of Sciences 117 (35), 21450-21458, 2020 | 34 | 2020 |
The structure and function of the mouse tyrosinase locus D Seruggia, S Josa, A Fernandez, L Montoliu Pigment Cell & Melanoma Research 34 (2), 212-221, 2021 | 25 | 2021 |
Controlled removal of a nonviral episomal vector from transfected cells S Rupprecht, C Hagedorn, D Seruggia, T Magnusson, E Wagner, M Ogris, ... Gene 466 (1-2), 36-42, 2010 | 24 | 2010 |
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells S Mehta, A Buyanbat, Y Kai, O Karayel, SR Goldman, D Seruggia, ... Cell chemical biology 29 (8), 1273-1287. e8, 2022 | 19 | 2022 |
Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity T Shahin, HS Kuehn, MR Shoeb, L Gawriyski, S Giuliani, P Repiscak, ... Science immunology 6 (65), eabe3981, 2021 | 18 | 2021 |
Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer H Singh, D Seruggia, S Madha, M Saxena, AK Nagaraja, Z Wu, J Zhou, ... Genes & Development 36 (1-2), 38-52, 2022 | 12 | 2022 |