| CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours H Xu, M Di Antonio, S McKinney, V Mathew, B Ho, NJ O’Neil, ND Santos, ... Nature communications 8 (1), 14432, 2017 | 538 | 2017 |
| R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants PC Stirling, YA Chan, SW Minaker, MJ Aristizabal, I Barrett, ... Genes & development 26 (2), 163-175, 2012 | 277 | 2012 |
| Genome-wide profiling of yeast DNA: RNA hybrid prone sites with DRIP-chip YA Chan, MJ Aristizabal, PYT Lu, Z Luo, A Hamza, MS Kobor, PC Stirling, ... PLoS genetics 10 (4), e1004288, 2014 | 263 | 2014 |
| The interaction network of the chaperonin CCT C Dekker, PC Stirling, EA McCormack, H Filmore, A Paul, RL Brost, ... The EMBO journal 27 (13), 1827-1839, 2008 | 235 | 2008 |
| The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components PC Stirling, MS Bloom, T Solanki-Patil, S Smith, P Sipahimalani, Z Li, ... PLoS genetics 7 (4), e1002057, 2011 | 205 | 2011 |
| Quality control of cytoskeletal proteins and human disease VF Lundin, MR Leroux, PC Stirling Trends in biochemical sciences 35 (5), 288-297, 2010 | 129 | 2010 |
| Mechanisms of genome instability induced by RNA-processing defects YA Chan, P Hieter, PC Stirling Trends in Genetics 30 (6), 245-253, 2014 | 128 | 2014 |
| RECQ-like helicases Sgs1 and BLM regulate R-loop–associated genome instability EYC Chang, CA Novoa, MJ Aristizabal, Y Coulombe, R Segovia, ... Journal of Cell Biology 216 (12), 3991-4005, 2017 | 110 | 2017 |
| A yeast killer toxin screen provides insights into a/b toxin entry, trafficking, and killing mechanisms SY Carroll, PC Stirling, HEM Stimpson, E Gießelmann, MJ Schmitt, ... Developmental cell 17 (4), 552-560, 2009 | 110 | 2009 |
| PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates PC Stirling, J Cuéllar, GA Alfaro, F El Khadali, CT Beh, JM Valpuesta, ... Journal of Biological Chemistry 281 (11), 7012-7021, 2006 | 97 | 2006 |
| Convergent evolution of clamp-like binding sites in diverse chaperones PC Stirling, SF Bakhoum, AB Feigl, MR Leroux Nature structural & molecular biology 13 (10), 865-870, 2006 | 84 | 2006 |
| R loops and their composite cancer connections JP Wells, J White, PC Stirling Trends in cancer 5 (10), 619-631, 2019 | 79 | 2019 |
| Molecular clamp mechanism of substrate binding by hydrophobic coiled-coil residues of the archaeal chaperone prefoldin VF Lundin, PC Stirling, J Gomez-Reino, JC Mwenifumbo, JM Obst, ... Proceedings of the National Academy of Sciences 101 (13), 4367-4372, 2004 | 74 | 2004 |
| MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts EYC Chang, S Tsai, MJ Aristizabal, JP Wells, Y Coulombe, FF Busatto, ... Nature communications 10 (1), 4265, 2019 | 73 | 2019 |
| Divergent substrate-binding mechanisms reveal an evolutionary specialization of eukaryotic prefoldin compared to its archaeal counterpart J Martín-Benito, J Gomez-Reino, PC Stirling, VF Lundin, ... Structure 15 (1), 101-110, 2007 | 72 | 2007 |
| ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork S Kim, N Kang, SH Park, J Wells, T Hwang, E Ryu, B Kim, S Hwang, ... Nucleic acids research 48 (13), 7218-7238, 2020 | 67 | 2020 |
| Getting a grip on non‐native proteins PC Stirling, VF Lundin, MR Leroux EMBO reports 4 (6), 565-570, 2003 | 66 | 2003 |
| ARID1A regulates R-loop associated DNA replication stress S Tsai, LA Fournier, EY Chang, JP Wells, SW Minaker, YD Zhu, ... PLoS Genetics 17 (4), e1009238, 2021 | 65 | 2021 |
| Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression PC Stirling, M Srayko, KS Takhar, A Pozniakovsky, AA Hyman, MR Leroux Molecular biology of the cell 18 (6), 2336-2345, 2007 | 63 | 2007 |
| Human prefoldin inhibits amyloid-β (Aβ) fibrillation and contributes to formation of nontoxic Aβ aggregates KM Sörgjerd, T Zako, M Sakono, PC Stirling, MR Leroux, T Saito, ... Biochemistry 52 (20), 3532-3542, 2013 | 60 | 2013 |
