Peter Stirling
Peter Stirling
Associate Professor of Medical Genetics, University of British Columbia
Verified email at
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CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
H Xu, M Di Antonio, S McKinney, V Mathew, B Ho, NJ O’Neil, ND Santos, ...
Nature communications 8 (1), 14432, 2017
R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants
PC Stirling, YA Chan, SW Minaker, MJ Aristizabal, I Barrett, ...
Genes & development 26 (2), 163-175, 2012
Genome-wide profiling of yeast DNA: RNA hybrid prone sites with DRIP-chip
YA Chan, MJ Aristizabal, PYT Lu, Z Luo, A Hamza, MS Kobor, PC Stirling, ...
PLoS genetics 10 (4), e1004288, 2014
The interaction network of the chaperonin CCT
C Dekker, PC Stirling, EA McCormack, H Filmore, A Paul, RL Brost, ...
The EMBO journal 27 (13), 1827-1839, 2008
The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components
PC Stirling, MS Bloom, T Solanki-Patil, S Smith, P Sipahimalani, Z Li, ...
PLoS genetics 7 (4), e1002057, 2011
Quality control of cytoskeletal proteins and human disease
VF Lundin, MR Leroux, PC Stirling
Trends in biochemical sciences 35 (5), 288-297, 2010
Mechanisms of genome instability induced by RNA-processing defects
YA Chan, P Hieter, PC Stirling
Trends in Genetics 30 (6), 245-253, 2014
A yeast killer toxin screen provides insights into a/b toxin entry, trafficking, and killing mechanisms
SY Carroll, PC Stirling, HEM Stimpson, E Gießelmann, MJ Schmitt, ...
Developmental cell 17 (4), 552-560, 2009
RECQ-like helicases Sgs1 and BLM regulate R-loop–associated genome instability
EYC Chang, CA Novoa, MJ Aristizabal, Y Coulombe, R Segovia, ...
Journal of Cell Biology 216 (12), 3991-4005, 2017
PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates
PC Stirling, J Cuéllar, GA Alfaro, F El Khadali, CT Beh, JM Valpuesta, ...
Journal of Biological Chemistry 281 (11), 7012-7021, 2006
Convergent evolution of clamp-like binding sites in diverse chaperones
PC Stirling, SF Bakhoum, AB Feigl, MR Leroux
Nature structural & molecular biology 13 (10), 865-870, 2006
Molecular clamp mechanism of substrate binding by hydrophobic coiled-coil residues of the archaeal chaperone prefoldin
VF Lundin, PC Stirling, J Gomez-Reino, JC Mwenifumbo, JM Obst, ...
Proceedings of the National Academy of Sciences 101 (13), 4367-4372, 2004
Divergent substrate-binding mechanisms reveal an evolutionary specialization of eukaryotic prefoldin compared to its archaeal counterpart
J Martín-Benito, J Gomez-Reino, PC Stirling, VF Lundin, ...
Structure 15 (1), 101-110, 2007
Getting a grip on non‐native proteins
PC Stirling, VF Lundin, MR Leroux
EMBO reports 4 (6), 565-570, 2003
MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts
EYC Chang, S Tsai, MJ Aristizabal, JP Wells, Y Coulombe, FF Busatto, ...
Nature communications 10 (1), 4265, 2019
Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression
PC Stirling, M Srayko, KS Takhar, A Pozniakovsky, AA Hyman, MR Leroux
Molecular biology of the cell 18 (6), 2336-2345, 2007
R loops and their composite cancer connections
JP Wells, J White, PC Stirling
Trends in cancer 5 (10), 619-631, 2019
Human prefoldin inhibits amyloid-β (Aβ) fibrillation and contributes to formation of nontoxic Aβ aggregates
KM Sörgjerd, T Zako, M Sakono, PC Stirling, MR Leroux, T Saito, ...
Biochemistry 52 (20), 3532-3542, 2013
ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork
S Kim, N Kang, SH Park, J Wells, T Hwang, E Ryu, B Kim, S Hwang, ...
Nucleic acids research 48 (13), 7218-7238, 2020
Canonical DNA repair pathways influence R-loop-driven genome instability
PC Stirling, P Hieter
Journal of molecular biology 429 (21), 3132-3138, 2017
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