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John J Kelly, Ph.D.
John J Kelly, Ph.D.
Research Associate II, Western University
Adresse e-mail validée de uwo.ca
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Alström Syndrome protein ALMS1 localizes to basal bodies of cochlear hair cells and regulates cilium-dependent planar cell polarity
D Jagger, G Collin, J Kelly, E Towers, G Nevill, C Longo-Guess, J Benson, ...
Human molecular genetics 20 (3), 466-481, 2011
1022011
Mechanisms linking connexin mutations to human diseases
JJ Kelly, J Simek, DW Laird
Cell and tissue research 360 (3), 701-721, 2015
902015
A Germline Variant in the PANX1 Gene Has Reduced Channel Function and Is Associated with Multisystem Dysfunction
Q Shao, K Lindstrom, R Shi, J Kelly, A Schroeder, J Juusola, KL Levine, ...
Journal of Biological Chemistry 291 (24), 12432-12443, 2016
822016
Panx1 regulates cellular properties of keratinocytes and dermal fibroblasts in skin development and wound healing
S Penuela, JJ Kelly, JM Churko, KJ Barr, AC Berger, DW Laird
Journal of Investigative Dermatology 134 (7), 2026-2035, 2014
772014
Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss
J Chen, N Ingham, J Kelly, S Jadeja, D Goulding, J Pass, VB Mahajan, ...
PLoS Genet 10 (10), e1004688, 2014
622014
Mutations in Cx30 that are linked to skin disease and non-syndromic hearing loss exhibit several distinct cellular pathologies
AC Berger, JJ Kelly, P Lajoie, Q Shao, DW Laird
Journal of cell science 127 (8), 1751-1764, 2014
552014
Safe harbor-targeted CRISPR-Cas9 homology-independent targeted integration for multimodality reporter gene-based cell tracking
JJ Kelly, M Saee-Marand, NN Nyström, MM Evans, Y Chen, FM Martinez, ...
Science advances 7 (4), eabc3791, 2021
502021
Connexin30-mediated intercellular communication plays an essential role in epithelial repair in the cochlea
A Forge, DJ Jagger, JJ Kelly, RR Taylor
Journal of cell science 126 (7), 1703-1712, 2013
402013
Caprin-1 is a target of the deafness gene Pou4f3 and is recruited to stress granules in cochlear hair cells in response to ototoxic damage
ER Towers, JJ Kelly, R Sud, JE Gale, SJ Dawson
Journal of cell science 124 (7), 1145-1155, 2011
342011
Development of gap junctional intercellular communication within the lateral wall of the rat cochlea
JJ Kelly, A Forge, DJ Jagger
Neuroscience 180, 360-369, 2011
302011
Double deletion of Panx1 and Panx3 affects skin and bone but not hearing
JM Abitbol, BL O’Donnell, CB Wakefield, E Jewlal, JJ Kelly, K Barr, ...
Journal of Molecular Medicine 97 (5), 723-736, 2019
272019
Pannexin 1 regulates adipose stromal cell differentiation and fat accumulation
VR Lee, KJ Barr, JJ Kelly, D Johnston, CFC Brown, KP Robb, ...
Scientific reports 8 (1), 1-14, 2018
272018
Differential effects of pannexins on noise-induced hearing loss
JM Abitbol, JJ Kelly, K Barr, AL Schormans, DW Laird, BL Allman
Biochemical Journal 473 (24), 4665-4680, 2016
272016
Specific functional pathologies of Cx43 mutations associated with oculodentodigital dysplasia
JJ Kelly, JL Esseltine, Q Shao, EW Jabs, J Sampson, M Auranen, D Bai, ...
Molecular biology of the cell 27 (14), 2172-2185, 2016
272016
Cx30 exhibits unique characteristics including a long half-life when assembled into gap junctions
JJ Kelly, Q Shao, DJ Jagger, DW Laird
Journal of cell science 128 (21), 3947-3960, 2015
262015
Contractility in type III cochlear fibrocytes is dependent on non-muscle myosin II and intercellular gap junctional coupling
JJ Kelly, A Forge, DJ Jagger
Journal of the Association for Research in Otolaryngology 13 (4), 473-484, 2012
252012
The G60S Cx43 mutant enhances keratinocyte proliferation and differentiation
JM Churko, JJ Kelly, A MacDonald, J Lee, J Sampson, D Bai, DW Laird
Experimental dermatology 21 (8), 612-618, 2012
222012
Induction of cell death and gain-of-function properties of connexin26 mutants predict severity of skin disorders and hearing loss
ER Press, Q Shao, JJ Kelly, K Chin, A Alaga, DW Laird
Journal of Biological Chemistry 292 (23), 9721-9732, 2017
212017
Engineering Circulating Tumor Cells as Novel Cancer Theranostics
KM Parkins, VP Dubois, JJ Kelly, Y Chen, NN Knier, PJ Foster, JA Ronald
Theranostics 10 (17), 7925, 2020
152020
Mice harbouring an oculodentodigital dysplasia-linked Cx43 G60S mutation have severe hearing loss
JM Abitbol, JJ Kelly, KJ Barr, BL Allman, DW Laird
Journal of Cell Science 131 (9), jcs214635, 2018
152018
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