Lesley Ann Howell
Lesley Ann Howell
Lecturer in Pharmaceutical/Medicinal Chemistry, Queen Mary, University of London
Verified email at - Homepage
Cited by
Cited by
Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors
X Viñals, E Moreno, L Lanfumey, A Cordomí, A Pastor, R de La Torre, ...
PLoS biology 13 (7), e1002194, 2015
Orexin–corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine
G Navarro, C Quiroz, D Moreno-Delgado, A Sierakowiak, K McDowell, ...
Journal of Neuroscience 35 (17), 6639-6653, 2015
Singular location and signaling profile of adenosine A2A-cannabinoid CB1 receptor heteromers in the dorsal striatum
E Moreno, A Chiarlone, M Medrano, M Puigdellívol, L Bibic, LA Howell, ...
Neuropsychopharmacology 43 (5), 964-977, 2018
Design and characterization of superpotent bivalent ligands targeting oxytocin receptor dimers via a channel-like structure
M Busnelli, G Kleinau, M Muttenthaler, S Stoev, M Manning, L Bibic, ...
Journal of medicinal chemistry 59 (15), 7152-7166, 2016
Small‐molecule and peptide inhibitors of the pro‐survival protein Mcl‐1
AM Beekman, LA Howell
ChemMedChem 11 (8), 802-813, 2016
A small molecule that induces assembly of a four way DNA junction at low temperature
LA Howell, ZAE Waller, R Bowater, M O'Connell, M Searcey
Chemical Communications 47 (29), 8262-8264, 2011
Design and synthesis of threading intercalators to target DNA
LA Howell, R Gulam, A Mueller, MA O’Connell, M Searcey
Bioorganic & medicinal chemistry letters 20 (23), 6956-6959, 2010
Synthesis of small molecules targeting multiple DNA structures using click chemistry
LA Howell, RA Bowater, MA O'Connell, AP Reszka, S Neidle, M Searcey
ChemMedChem 7 (5), 792-804, 2012
Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry
LA Howell, A Howman, MA O’Connell, A Mueller, M Searcey
Bioorganic & medicinal chemistry letters 19 (20), 5880-5883, 2009
Rac1 plays a role in CXCL12 but not CCL3-induced chemotaxis and Rac1 GEF inhibitor NSC23766 has off target effects on CXCR4
SC Mills, L Howell, A Beekman, L Stokes, A Mueller
Cellular signalling 42, 88-96, 2018
Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin
MMD Cominetti, SA Goffin, E Raffel, KD Turner, JC Ramoutar, ...
Bioorganic & Medicinal Chemistry Letters 25 (21), 4878-4880, 2015
Design and development of stapled transmembrane peptides that disrupt the activity of G-protein–coupled receptor oligomers
J Botta, L Bibic, P Killoran, PJ McCormick, LA Howell
Journal of Biological Chemistry 294 (45), 16587-16603, 2019
Targeting higher-order DNA: beyond the G-quadruplex
L Howell, M Searcey
ChemBioChem 10 (13), 2139-2143, 2009
Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease
D Moreno-Delgado, M Puigdellívol, E Moreno, M Rodríguez-Ruiz, J Botta, ...
Elife 9, e51093, 2020
Identification of Small‐Molecule Inhibitors of the Antiapoptotic Protein Myeloid Cell Leukaemia‐1 (Mcl‐1)
AM Beekman, MA O'Connell, LA Howell
ChemMedChem 11 (8), 840-844, 2016
Solid-phase synthesis of duocarmycin analogues and the effect of C-terminal substitution on biological activity
MJ Stephenson, LA Howell, MA O’connell, KR Fox, C Adcock, J Kingston, ...
The Journal of organic chemistry 80 (19), 9454-9467, 2015
A natural product inspired fragment-based approach towards the development of novel anti-bacterial agents
MJ Austin, SJ Hearnshaw, LA Mitchenall, PJ McDermott, LA Howell, ...
MedChemComm 7 (7), 1387-1391, 2016
Identification and characterisation of a G-quadruplex forming sequence in the promoter region of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)
ZAE Waller, LA Howell, CJ MacDonald, MA O’Connell, M Searcey
Biochemical and Biophysical Research Communications 447 (1), 128-132, 2014
Unveiling the “Three‐Finger Pharmacophore” Required for p53–MDM2 Inhibition by Saturation‐Transfer Difference (STD) NMR Initial Growth‐Rates Approach
J Angulo, SA Goffin, D Gandhi, M Searcey, LA Howell
Chemistry–A European Journal 22 (17), 5858-5862, 2016
Peptide‐Directed Binding for the Discovery of Modulators of α‐Helix‐Mediated Protein–Protein Interactions: Proof‐of‐Concept Studies with the Apoptosis Regulator Mcl‐1
AM Beekman, MA O'Connell, LA Howell
Angewandte Chemie 129 (35), 10582-10586, 2017
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