Bruce Verchere
Bruce Verchere
Professor of Medicine University of British Columbia and Child & Family Research Institute
Verified email at - Homepage
TitleCited byYear
Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.
SE Kahn, S Andrikopoulos, CB Verchere
Diabetes 48 (2), 241-253, 1999
β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment
LR Brunham, JK Kruit, TD Pape, JM Timmins, AQ Reuwer, Z Vasanji, ...
Nature medicine 13 (3), 340-347, 2007
Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide
CB Verchere, DA D'Alessio, RD Palmiter, GC Weir, S Bonner-Weir, ...
Proceedings of the National Academy of Sciences 93 (8), 3492-3496, 1996
Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood
JD Trudeau, C Kelly-Smith, CB Verchere, JF Elliott, JP Dutz, DT Finegood, ...
The Journal of clinical investigation 111 (2), 217-223, 2003
The flavanol (−)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP …
F Meng, A Abedini, A Plesner, CB Verchere, DP Raleigh
Biochemistry 49 (37), 8127-8133, 2010
Islet amyloid polypeptide and type 2 diabetes
L Marzban, K Park, CB Verchere
Experimental gerontology 38 (4), 347-351, 2003
Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?
S Zraika, RL Hull, CB Verchere, A Clark, KJ Potter, PE Fraser, DP Raleigh, ...
Diabetologia 53 (6), 1046-1056, 2010
Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts
KJ Potter, A Abedini, P Marek, AM Klimek, S Butterworth, M Driscoll, ...
Proceedings of the National Academy of Sciences 107 (9), 4305-4310, 2010
IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction
C Westwell-Roper, DL Dai, G Soukhatcheva, KJ Potter, N van Rooijen, ...
The journal of immunology 187 (5), 2755-2765, 2011
A multi-year analysis of islet transplantation compared with intensive medical therapy on progression of complications in type 1 diabetes
GL Warnock, DM Thompson, RM Meloche, RJ Shapiro, Z Ao, P Keown, ...
Transplantation 86 (12), 1762-1766, 2008
Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets
JD Johnson, Z Ao, P Ao, H Li, LJ Dai, Z He, M Tee, KJ Potter, AM Klimek, ...
Cell transplantation 18 (8), 833-845, 2009
Cholesterol in islet dysfunction and type 2 diabetes
LR Brunham, JK Kruit, CB Verchere, MR Hayden
The Journal of clinical investigation 118 (2), 403-408, 2008
HDL and LDL cholesterol significantly influence β-cell function in type 2 diabetes mellitus
JK Kruit, LR Brunham, CB Verchere, MR Hayden
Current opinion in lipidology 21 (3), 178-185, 2010
miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets
N Wijesekara, L Zhang, MH Kang, T Abraham, A Bhattacharjee, ...
Diabetes 61 (3), 653-658, 2012
Resident macrophages mediate islet amyloid polypeptide–induced islet IL-1β production and β-cell dysfunction
CY Westwell-Roper, JA Ehses, CB Verchere
Diabetes 63 (5), 1698-1711, 2014
Increased dietary fat promotes islet amyloid formation and β-cell secretory dysfunction in a transgenic mouse model of islet amyloid
RL Hull, S Andrikopoulos, CB Verchere, J Vidal, F Wang, M Cnop, ...
Diabetes 52 (2), 372-379, 2003
Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice
S Ghosh, M Khazaei, F Moien-Afshari, LS Ang, DJ Granville, CB Verchere, ...
American Journal of Physiology-Renal Physiology 296 (4), F700-F708, 2009
The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site
J Wang, J Xu, J Finnerty, M Furuta, DF Steiner, CB Verchere
Diabetes 50 (3), 534-539, 2001
Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function …
JK Kruit, PHC Kremer, L Dai, R Tang, P Ruddle, W de Haan, LR Brunham, ...
Diabetologia 53 (6), 1110-1119, 2010
Role of β-cell prohormone convertase (PC) 1/3 in processing of pro-islet amyloid polypeptide
L Marzban, G Trigo-Gonzalez, X Zhu, CJ Rhodes, PA Halban, DF Steiner, ...
Diabetes 53 (1), 141-148, 2004
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