Finding the missing heritability of complex diseases TA Manolio, FS Collins, NJ Cox, DB Goldstein, LA Hindorff, DJ Hunter, ... Nature 461 (7265), 747-753, 2009 | 9999 | 2009 |
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes SFA Grant, G Thorleifsson, I Reynisdottir, R Benediktsson, A Manolescu, ... Nature genetics 38 (3), 320-323, 2006 | 2886 | 2006 |
Variant of TREM2 Associated with the Risk of Alzheimer's Disease T Jonsson, H Stefansson, S Steinberg, I Jonsdottir, PV Jonsson, ... New England Journal of Medicine 368 (2), 107-116, 2013 | 2805 | 2013 |
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk J Dupuis, C Langenberg, I Prokopenko, R Saxena, N Soranzo, ... Nature genetics 42 (2), 105-116, 2010 | 2589 | 2010 |
Rate of de novo mutations and the importance of father’s age to disease risk A Kong, ML Frigge, G Masson, S Besenbacher, P Sulem, G Magnusson, ... Nature 488 (7412), 471-475, 2012 | 2568 | 2012 |
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes E Zeggini, LJ Scott, R Saxena, BF Voight, JL Marchini, T Hu, ... Nature genetics 40 (5), 638-645, 2008 | 2318 | 2008 |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease H Schunkert, IR König, S Kathiresan, MP Reilly, TL Assimes, H Holm, ... Nature genetics 43 (4), 333-338, 2011 | 2260 | 2011 |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC ... Nature genetics 44 (9), 981-990, 2012 | 2210 | 2012 |
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis BF Voight, LJ Scott, V Steinthorsdottir, AP Morris, C Dina, RP Welch, ... Nature genetics 42 (7), 579-589, 2010 | 2204 | 2010 |
A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline T Jonsson, JK Atwal, S Steinberg, J Snaedal, PV Jonsson, S Bjornsson, ... Nature 488 (7409), 96-99, 2012 | 2182 | 2012 |
Neuregulin 1 and susceptibility to schizophrenia H Stefansson, H Petursson, E Sigurdsson, V Steinthorsdottir, ... The American Journal of Human Genetics 71 (4), 877-892, 2002 | 2108 | 2002 |
Missing heritability and strategies for finding the underlying causes of complex disease EE Eichler, J Flint, G Gibson, A Kong, SM Leal, JH Moore, JH Nadeau Nature reviews genetics 11 (6), 446-450, 2010 | 2083 | 2010 |
Large recurrent microdeletions associated with schizophrenia H Stefansson, D Rujescu, S Cichon, OPH Pietiläinen, A Ingason, ... nature 455 (7210), 232, 2008 | 2056 | 2008 |
A high-resolution recombination map of the human genome A Kong, DF Gudbjartsson, J Sainz, GM Jonsdottir, SA Gudjonsson, ... Nature genetics 31 (3), 241-247, 2002 | 2038 | 2002 |
A common variant on chromosome 9p21 affects the risk of myocardial infarction A Helgadottir, G Thorleifsson, A Manolescu, S Gretarsdottir, T Blondal, ... Science 316 (5830), 1491-1493, 2007 | 1973 | 2007 |
Common variants conferring risk of schizophrenia H Stefansson, RA Ophoff, S Steinberg, OA Andreassen, S Cichon, ... Nature 460 (7256), 744, 2009 | 1968 | 2009 |
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease TE Thorgeirsson, F Geller, P Sulem, T Rafnar, A Wiste, KP Magnusson, ... Nature 452 (7187), 638-642, 2008 | 1686 | 2008 |
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity G Thorleifsson, GB Walters, DF Gudbjartsson, V Steinthorsdottir, P Sulem, ... Nature genetics 41 (1), 18-24, 2009 | 1666 | 2009 |
Sequential imputations and Bayesian missing data problems A Kong, JS Liu, WH Wong Journal of the American statistical association 89 (425), 278-288, 1994 | 1635 | 1994 |
Genetics of gene expression and its effect on disease V Emilsson, G Thorleifsson, B Zhang, AS Leonardson, F Zink, J Zhu, ... Nature 452 (7186), 423-428, 2008 | 1619 | 2008 |