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Mohamad-Gabriel Alameh
Mohamad-Gabriel Alameh
University of Pennsylvania and Children Hospital of Philadelphia
Adresse e-mail validée de pennmedicine.upenn.edu - Page d'accueil
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Nanomaterial Delivery Systems for mRNA Vaccines
MGADW Michael D. Buschmann 1, *, Manuel J. Carrasco 1, Suman Alishetty 1 ...
Vaccines 9 (65), 2021
4312021
D614G spike mutation increases SARS CoV-2 susceptibility to neutralization
D Weissman, MG Alameh, T de Silva, P Collini, H Hornsby, R Brown, ...
Cell host & microbe 29 (1), 23-31. e4, 2021
3672021
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
MG Alameh, I Tombácz, E Bettini, K Lederer, S Ndeupen, C Sittplangkoon, ...
Immunity 54 (12), 2877-2892. e7, 2021
3622021
An ionizable lipid toolbox for RNA delivery
X Han, H Zhang, K Butowska, KL Swingle, MG Alameh, D Weissman, ...
Nature communications 12 (1), 7233, 2021
2732021
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination
J Tang, C Zeng, TM Cox, C Li, YM Son, IS Cheon, Y Wu, S Behl, JJ Taylor, ...
Science immunology 7 (76), eadd4853, 2022
2172022
Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration
MJ Carrasco, S Alishetty, MG Alameh, H Said, L Wright, M Paige, ...
Communications biology 4 (1), 956, 2021
2082021
A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes
CP Arevalo, MJ Bolton, V Le Sage, N Ye, C Furey, H Muramatsu, ...
Science 378 (6622), 899-904, 2022
1622022
Scalable mRNA and siRNA lipid nanoparticle production using a parallelized microfluidic device
SJ Shepherd, CC Warzecha, S Yadavali, R El-Mayta, MG Alameh, ...
Nano letters 21 (13), 5671-5680, 2021
1572021
Ionizable lipid nanoparticles for in utero mRNA delivery
RS Riley, MV Kashyap, MM Billingsley, B White, MG Alameh, SK Bose, ...
Science advances 7 (3), eaba1028, 2021
1352021
siRNA delivery with chitosan: influence of chitosan molecular weight, degree of deacetylation, and amine to phosphate ratio on in vitro silencing efficiency, hemocompatibility …
M Alameh, M Lavertu, N Tran-Khanh, CY Chang, F Lesage, M Bail, ...
Biomacromolecules 19 (1), 112-131, 2018
1242018
Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPs
I Tombácz, D Laczkó, H Shahnawaz, H Muramatsu, A Natesan, ...
Molecular Therapy 29 (11), 3293-3304, 2021
1202021
Low molecular weight chitosan nanoparticulate system at low N: P ratio for nontoxic polynucleotide delivery
M Alameh, D DeJesus, M Jean, V Darras, M Thibault, M Lavertu, ...
International journal of nanomedicine, 1399-1414, 2012
1082012
Vaccine technologies and platforms for infectious diseases: Current progress, challenges, and opportunities
M Ghattas, G Dwivedi, M Lavertu, MG Alameh
Vaccines 9 (12), 1490, 2021
942021
Chitosan-based therapeutic nanoparticles for combination gene therapy and gene silencing of in vitro cell lines relevant to type 2 diabetes
M Jean, M Alameh, D De Jesus, M Thibault, M Lavertu, V Darras, M Nelea, ...
European Journal of Pharmaceutical Sciences 45 (1-2), 138-149, 2012
912012
Messenger RNA-Based Vaccines Against Infectious Diseases
MG Alameh, D Weissman, N Pardi
Springer, Berlin, Heidelberg, 2020
852020
Dual spike and nucleocapsid mRNA vaccination confer protection against SARS-CoV-2 Omicron and Delta variants in preclinical models
RL Hajnik, JA Plante, Y Liang, MG Alameh, J Tang, SR Bonam, C Zhong, ...
Science translational medicine 14 (662), eabq1945, 2022
742022
Rational design of bisphosphonate lipid-like materials for mRNA delivery to the bone microenvironment
L Xue, N Gong, SJ Shepherd, X Xiong, X Liao, X Han, G Zhao, C Song, ...
Journal of the American Chemical Society 144 (22), 9926-9937, 2022
722022
Effective and safe gene-based delivery of GLP-1 using chitosan/plasmid-DNA therapeutic nanocomplexes in an animal model of type 2 diabetes
M Jean, M Alameh, MD Buschmann, A Merzouki
Gene therapy 18 (8), 807-816, 2011
702011
Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer
JR Melamed, SS Yerneni, ML Arral, ST LoPresti, N Chaudhary, ...
Science Advances 9 (4), eade1444, 2023
642023
Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy
KL Swingle, HC Safford, HC Geisler, AG Hamilton, AS Thatte, ...
Journal of the American Chemical Society 145 (8), 4691-4706, 2023
602023
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