Mohamad-Gabriel Alameh
Mohamad-Gabriel Alameh
University of Pennsylvania and Children Hospital of Philadelphia
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Nanomaterial Delivery Systems for mRNA Vaccines
MGADW Michael D. Buschmann 1, *, Manuel J. Carrasco 1, Suman Alishetty 1 ...
Vaccines 9 (65), 2021
D614G spike mutation increases SARS CoV-2 susceptibility to neutralization
D Weissman, MG Alameh, T de Silva, P Collini, H Hornsby, R Brown, ...
Cell host & microbe 29 (1), 23-31. e4, 2021
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
MG Alameh, I Tombácz, E Bettini, K Lederer, S Ndeupen, C Sittplangkoon, ...
Immunity 54 (12), 2877-2892. e7, 2021
An ionizable lipid toolbox for RNA delivery
X Han, H Zhang, K Butowska, KL Swingle, MG Alameh, D Weissman, ...
Nature communications 12 (1), 7233, 2021
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination
J Tang, C Zeng, TM Cox, C Li, YM Son, IS Cheon, Y Wu, S Behl, JJ Taylor, ...
Science immunology 7 (76), eadd4853, 2022
Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration
MJ Carrasco, S Alishetty, MG Alameh, H Said, L Wright, M Paige, ...
Communications biology 4 (1), 956, 2021
Scalable mRNA and siRNA lipid nanoparticle production using a parallelized microfluidic device
SJ Shepherd, CC Warzecha, S Yadavali, R El-Mayta, MG Alameh, ...
Nano letters 21 (13), 5671-5680, 2021
A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes
CP Arevalo, MJ Bolton, V Le Sage, N Ye, C Furey, H Muramatsu, ...
Science 378 (6622), 899-904, 2022
Ionizable lipid nanoparticles for in utero mRNA delivery
RS Riley, MV Kashyap, MM Billingsley, B White, MG Alameh, SK Bose, ...
Science advances 7 (3), eaba1028, 2021
siRNA delivery with chitosan: influence of chitosan molecular weight, degree of deacetylation, and amine to phosphate ratio on in vitro silencing efficiency, hemocompatibility …
M Alameh, M Lavertu, N Tran-Khanh, CY Chang, F Lesage, M Bail, ...
Biomacromolecules 19 (1), 112-131, 2018
Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPs
I Tombácz, D Laczkó, H Shahnawaz, H Muramatsu, A Natesan, ...
Molecular Therapy 29 (11), 3293-3304, 2021
Low molecular weight chitosan nanoparticulate system at low N: P ratio for nontoxic polynucleotide delivery
M Alameh, D DeJesus, M Jean, V Darras, M Thibault, M Lavertu, ...
International journal of nanomedicine, 1399-1414, 2012
Chitosan-based therapeutic nanoparticles for combination gene therapy and gene silencing of in vitro cell lines relevant to type 2 diabetes
M Jean, M Alameh, D De Jesus, M Thibault, M Lavertu, V Darras, M Nelea, ...
European Journal of Pharmaceutical Sciences 45 (1-2), 138-149, 2012
Vaccine technologies and platforms for infectious diseases: Current progress, challenges, and opportunities
M Ghattas, G Dwivedi, M Lavertu, MG Alameh
Vaccines 9 (12), 1490, 2021
Messenger RNA-Based Vaccines Against Infectious Diseases
MG Alameh, D Weissman, N Pardi
Springer, Berlin, Heidelberg, 2020
Effective and safe gene-based delivery of GLP-1 using chitosan/plasmid-DNA therapeutic nanocomplexes in an animal model of type 2 diabetes
M Jean, M Alameh, MD Buschmann, A Merzouki
Gene therapy 18 (8), 807-816, 2011
Dual spike and nucleocapsid mRNA vaccination confer protection against SARS-CoV-2 Omicron and Delta variants in preclinical models
RL Hajnik, JA Plante, Y Liang, MG Alameh, J Tang, SR Bonam, C Zhong, ...
Science translational medicine 14 (662), eabq1945, 2022
Rational design of bisphosphonate lipid-like materials for mRNA delivery to the bone microenvironment
L Xue, N Gong, SJ Shepherd, X Xiong, X Liao, X Han, G Zhao, C Song, ...
Journal of the American Chemical Society 144 (22), 9926-9937, 2022
Chitosanase-based method for RNA isolation from cells transfected with chitosan/siRNA nanocomplexes for real-time RT-PCR in gene silencing
M Alameh, M Jean, D DeJesus, MD Buschmann, A Merzouki
International journal of nanomedicine, 473-481, 2010
Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer
JR Melamed, SS Yerneni, ML Arral, ST LoPresti, N Chaudhary, ...
Science Advances 9 (4), eade1444, 2023
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