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Alex J Bott
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Oncogenic Myc induces expression of glutamine synthetase through promoter demethylation
AJ Bott, IC Peng, Y Fan, B Faubert, L Zhao, J Li, S Neidler, Y Sun, N Jaber, ...
Cell metabolism 22 (6), 1068-1077, 2015
2312015
TRIM21 ubiquitylates SQSTM1/p62 and suppresses protein sequestration to regulate redox homeostasis
JA Pan, Y Sun, YP Jiang, AJ Bott, N Jaber, Z Dou, B Yang, JS Chen, ...
Molecular cell 61 (5), 720-733, 2016
2222016
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure
AA Cluntun, R Badolia, S Lettlova, KM Parnell, TS Shankar, NA Diakos, ...
Cell metabolism 33 (3), 629-648. e10, 2021
1482021
Glutamine anabolism plays a critical role in pancreatic cancer by coupling carbon and nitrogen metabolism
AJ Bott, J Shen, C Tonelli, L Zhan, N Sivaram, YP Jiang, X Yu, V Bhatt, ...
Cell reports 29 (5), 1287-1298. e6, 2019
1332019
Regulation of tumor initiation by the mitochondrial pyruvate carrier
CL Bensard, DR Wisidagama, KA Olson, JA Berg, NM Krah, JC Schell, ...
Cell metabolism 31 (2), 284-300. e7, 2020
1242020
The pleiotropic effects of glutamine metabolism in cancer
AJ Bott, S Maimouni, WX Zong
Cancers 11 (6), 770, 2019
1032019
SCCA1/SERPINB3 promotes oncogenesis and epithelial–mesenchymal transition via the unfolded protein response and IL6 signaling
N Sheshadri, JM Catanzaro, AJ Bott, Y Sun, E Ullman, EI Chen, JA Pan, ...
Cancer research 74 (21), 6318-6329, 2014
762014
Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase
KG Hicks, AA Cluntun, HL Schubert, SR Hackett, JA Berg, PG Leonard, ...
Science 379 (6636), 996-1003, 2023
352023
Glutamine synthetase limits β-catenin–mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1
W Dai, J Shen, J Yan, AJ Bott, S Maimouni, HQ Daguplo, Y Wang, ...
The Journal of clinical investigation 132 (24), 2022
182022
XPRESSyourself: Enhancing, standardizing, and automating ribosome profiling computational analyses yields improved insight into data
JA Berg, JR Belyeu, JT Morgan, Y Ouyang, AJ Bott, AR Quinlan, J Gertz, ...
PLOS Computational Biology 16 (1), e1007625, 2020
152020
Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2–dependent glutaminolysis pathway
P Wei, AJ Bott, AA Cluntun, JT Morgan, CN Cunningham, JC Schell, ...
Science Advances 8 (39), eabq0117, 2022
132022
SREBP1 regulates mitochondrial metabolism in oncogenic KRAS expressing NSCLC
CF Ruiz, ED Montal, JA Haley, AJ Bott, JD Haley
FASEB journal: official publication of the Federation of American Societies …, 2020
132020
Maestro of the SereNADe: SLC25A51 orchestrates mitochondrial NAD+
Y Ouyang, AJ Bott, J Rutter
Trends in biochemical sciences 46 (5), 348-350, 2021
72021
Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction
JM Winter, HL Fresenius, CN Cunningham, P Wei, HR Keys, J Berg, ...
Elife 11, e82860, 2022
62022
Spectrophotometric determination of glutamine synthetase activity in cultured cells
IC Peng, AJ Bott, WX Zong
Bio-protocol 6 (19), e1959-e1959, 2016
42016
XPRESSyourself: enhancing and automating the ribosome profiling and RNA-Seq analysis toolkit
JA Berg, JR Belyeu, JT Morgan, AJ Bott, Y Ouyang, AR Quinlan, J Gertz, ...
bioRxiv, 704320, 2019
22019
Abstract 2440 Regulation of the Mitochondrial Pyruvate Carrier by the Wnt/beta-catenin pathway
L Cedeño-Rosario, N Abdi, A Bott, J Youngs, J Rutter
Journal of Biological Chemistry 300 (3), 2024
2024
Abstract C058: Identifying cell-intrinsic drivers of transcriptional plasticity in pancreatic cancer
YE Tong, WE Katan, A Bott, J Joung, AK Shalek, PS Winter, S Raghavan
Cancer Research 84 (2_Supplement), C058-C058, 2024
2024
Mitochondrial pyruvate supports lymphoma proliferation by fueling a non-canonical glutamine metabolism pathway
P Wei, AJ Bott, AA Cluntun, JT Morgan, CN Cunningham, JC Schell, ...
bioRxiv, 2021.08. 26.457847, 2021
2021
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