| Nrf2–ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases I Buendia, P Michalska, E Navarro, I Gameiro, J Egea, R Leon Pharmacology & therapeutics 157, 84-104, 2016 | 565 | 2016 |
| Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach A Cuadrado, G Manda, A Hassan, MJ Alcaraz, C Barbas, A Daiber, ... Pharmacological reviews 70 (2), 348-383, 2018 | 536 | 2018 |
| Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's disease R Leon, AG Garcia, J Marco‐Contelles Medicinal research reviews 33 (1), 139-189, 2013 | 467 | 2013 |
| Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection J Egea, I Buendia, E Parada, E Navarro, R Leon, MG Lopez Biochemical pharmacology 97 (4), 463-472, 2015 | 295 | 2015 |
| Tacripyrines, the first tacrine− dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer’s disease J Marco-Contelles, R León, C De Los Ríos, A Samadi, M Bartolini, ... Journal of medicinal chemistry 52 (9), 2724-2732, 2009 | 174 | 2009 |
| Novel Multipotent Tacrine− Dihydropyridine Hybrids with Improved Acetylcholinesterase Inhibitory and Neuroprotective Activities as Potential Drugs for the Treatment of … J Marco-Contelles, R León, C de Los Ríos, A Guglietta, J Terencio, ... Journal of medicinal chemistry 49 (26), 7607-7610, 2006 | 145 | 2006 |
| Catalytic enantioselective assembly of complex molecules containing embedded quaternary stereogenic centres from simple anisidine derivatives R Leon, A Jawalekar, T Redert, MJ Gaunt Chemical Science 2 (8), 1487-1490, 2011 | 127 | 2011 |
| Neuroprotective effect of melatonin against ischemia is partially mediated by alpha‐7 nicotinic receptor modulation and HO‐1 overexpression E Parada, I Buendia, R León, P Negredo, A Romero, A Cuadrado, ... Journal of pineal research 56 (2), 204-212, 2014 | 126 | 2014 |
| The antioxidant additive approach for Alzheimer’s disease therapy: new ferulic (lipoic) acid plus melatonin modified tacrines as cholinesterases inhibitors, direct antioxidants … M Benchekroun, A Romero, J Egea, R León, P Michalska, I Buendía, ... Journal of medicinal chemistry 59 (21), 9967-9973, 2016 | 101 | 2016 |
| New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties R León, C de los Ríos, J Marco-Contelles, O Huertas, X Barril, FJ Luque, ... Bioorganic & medicinal chemistry 16 (16), 7759-7769, 2008 | 95 | 2008 |
| The angiotensin‐(1‐7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation A Romero, Á San Hipólito‐Luengo, LA Villalobos, S Vallejo, I Valencia, ... Aging Cell 18 (3), e12913, 2019 | 92 | 2019 |
| Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1, 8-naphthyridine derivatives C De Los Ríos, J Egea, J Marco-Contelles, R León, A Samadi, I Iriepa, ... Journal of medicinal chemistry 53 (14), 5129-5143, 2010 | 80 | 2010 |
| Synthesis, acetylcholinesterase inhibition and neuroprotective activity of new tacrine analogues R León, J Marco-Contelles, AG García, M Villarroya Bioorganic & medicinal chemistry 13 (4), 1167-1175, 2005 | 78 | 2005 |
| Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer’s disease I Gameiro, P Michalska, G Tenti, Á Cores, I Buendia, AI Rojo, ... Scientific reports 7 (1), 45701, 2017 | 71 | 2017 |
| A step further towards multitarget drugs for Alzheimer and neuronal vascular diseases: targeting the cholinergic system, amyloid-β aggregation and Ca2++ dyshomeostasis R Leon, J Marco-Contelles Current medicinal chemistry 18 (4), 552-576, 2011 | 70 | 2011 |
| New multipotent tetracyclic tacrines with neuroprotective activity J Marco-Contelles, R León, C de los Ríos, AG García, MG López, ... Bioorganic & medicinal chemistry 14 (24), 8176-8185, 2006 | 67 | 2006 |
| Synthesis and biological evaluation of new 4H-pyrano [2, 3-b] quinoline derivatives that block acetylcholinesterase and cell calcium signals, and cause neuroprotection against … J Marco-Contelles, R León, MG López, AG García, M Villarroya European journal of medicinal chemistry 41 (12), 1464-1469, 2006 | 62 | 2006 |
| When it comes to an end: oxidative stress crosstalk with protein aggregation and neuroinflammation induce neurodegeneration P Michalska, R León Antioxidants 9 (8), 740, 2020 | 61 | 2020 |
| NRF2 regulation processes as a source of potential drug targets against neurodegenerative diseases Á Cores, M Piquero, M Villacampa, R León, JC Menéndez Biomolecules 10 (6), 904, 2020 | 61 | 2020 |
| Pharmacological doses of melatonin impede cognitive decline in tau‐related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux E Luengo, I Buendia, C Fernández‐Mendívil, P Trigo‐Alonso, P Negredo, ... Journal of Pineal Research 67 (1), e12578, 2019 | 61 | 2019 |
Manuela G. Lopez (Manuela García L...Universidad Autonoma de MadridVerified email at uam.es
