| Identification of RIP1 kinase as a specific cellular target of necrostatins A Degterev, J Hitomi, M Germscheid, IL Ch'en, O Korkina, X Teng, ... Nature chemical biology 4 (5), 313-321, 2008 | 2133 | 2008 |
| The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO DW Abbott, A Wilkins, JM Asara, LC Cantley Current biology 14 (24), 2217-2227, 2004 | 470 | 2004 |
| The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape CM Kang, DW Abbott, ST Park, CC Dascher, LC Cantley, RN Husson Genes & development 19 (14), 1692-1704, 2005 | 457 | 2005 |
| Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis JK Rathkey, J Zhao, Z Liu, Y Chen, J Yang, HC Kondolf, BL Benson, ... Science immunology 3 (26), eaat2738, 2018 | 417 | 2018 |
| A rapid method for determining protein kinase phosphorylation specificity JE Hutti, ET Jarrell, JD Chang, DW Abbott, P Storz, A Toker, LC Cantley, ... Nature methods 1 (1), 27-29, 2004 | 405 | 2004 |
| N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis M Karmakar, M Minns, EN Greenberg, J Diaz-Aponte, K Pestonjamasp, ... Nature communications 11 (1), 2212, 2020 | 323 | 2020 |
| BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair DW Abbott, ME Thompson, C Robinson-Benion, G Tomlinson, RA Jensen, ... Journal of Biological Chemistry 274 (26), 18808-18812, 1999 | 315 | 1999 |
| Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity RD Dorand, J Nthale, JT Myers, DS Barkauskas, S Avril, SM Chirieleison, ... Science 353 (6297), 399-403, 2016 | 308 | 2016 |
| Homophilic CD44 interactions mediate tumor cell aggregation and polyclonal metastasis in patient-derived breast cancer models X Liu, R Taftaf, M Kawaguchi, YF Chang, W Chen, D Entenberg, Y Zhang, ... Cancer discovery 9 (1), 96-113, 2019 | 305 | 2019 |
| Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2 BD Manning, MN Logsdon, AI Lipovsky, D Abbott, DJ Kwiatkowski, ... Genes & development 19 (15), 1773-1778, 2005 | 291 | 2005 |
| NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2 Y Yang, C Yin, A Pandey, D Abbott, C Sassetti, MA Kelliher Journal of Biological Chemistry 282 (50), 36223-36229, 2007 | 282 | 2007 |
| Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells DW Abbott, JT Holt, ML Freeman Journal of the National Cancer Institute 90 (13), 978-985, 1998 | 280 | 1998 |
| Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKɛ promotes cell transformation JE Hutti, RR Shen, DW Abbott, AY Zhou, KM Sprott, JM Asara, WC Hahn, ... Molecular cell 34 (4), 461-472, 2009 | 270 | 2009 |
| Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains DW Abbott, Y Yang, JE Hutti, S Madhavarapu, MA Kelliher, LC Cantley Molecular and cellular biology 27 (17), 6012-6025, 2007 | 223 | 2007 |
| Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses JT Tigno-Aranjuez, JM Asara, DW Abbott Genes & development 24 (23), 2666-2677, 2010 | 221 | 2010 |
| IκB kinase β phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-κB pathway JE Hutti, BE Turk, JM Asara, A Ma, LC Cantley, DW Abbott Molecular and cellular biology 27 (21), 7451-7461, 2007 | 205 | 2007 |
| Crystal structures of the full-length murine and human gasdermin D reveal mechanisms of autoinhibition, lipid binding, and oligomerization Z Liu, C Wang, J Yang, B Zhou, R Yang, R Ramachandran, DW Abbott, ... Immunity 51 (1), 43-49. e4, 2019 | 177 | 2019 |
| Active caspase-1 induces plasma membrane pores that precede pyroptotic lysis and are blocked by lanthanides HM Russo, J Rathkey, A Boyd-Tressler, MA Katsnelson, DW Abbott, ... The Journal of Immunology 197 (4), 1353-1367, 2016 | 175 | 2016 |
| Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation DW Abbott, JT Holt Journal of Biological Chemistry 274 (5), 2732-2742, 1999 | 168 | 1999 |
| ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways MF Tao, PC Scacheri, JM Marinis, EW Harhaj, LE Matesic, DW Abbott Current Biology 19 (15), 1255-1263, 2009 | 159 | 2009 |
