Sunil Laxman
Sunil Laxman
Institute for Stem Cell Science and Regenerative Medicine (inStem), UT Southwestern, U Washington
Verified email at - Homepage
Cited by
Cited by
Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A
BM Sutter, X Wu, S Laxman, BP Tu
Cell 154 (2), 403-415, 2013
Sulfur amino acids regulate translational capacity and metabolic homeostasis through modulation of tRNA thiolation
S Laxman, BM Sutter, X Wu, S Kumar, X Guo, DC Trudgian, H Mirzaei, ...
Cell 154 (2), 416-429, 2013
Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms
S Laxman, A Riechers, M Sadilek, F Schwede, JA Beavo
Proceedings of the National Academy of Sciences 103 (50), 19194-19199, 2006
Cyclic nucleotide signaling mechanisms in trypanosomes: possible targets for therapeutic agents
S Laxman, JA Beavo
Molecular interventions 7 (4), 203, 2007
Cyclic nucleotide specific phosphodiesterases of the kinetoplastida: a unified nomenclature
S Kunz, JA Beavo, MA D’Angelo, MM Flawia, SH Francis, A Johner, ...
Mol. Biochem. Parasitol 145 (1), 133-135, 2006
Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase
SC Tso, X Qi, WJ Gui, JL Chuang, LK Morlock, AL Wallace, K Ahmed, ...
Proceedings of the National Academy of Sciences 110 (24), 9728-9733, 2013
Npr2 regulates cellular utilization of glutamine for biosynthesis of nitrogen-containing metabolites through TORC1
S Laxman, BM Sutter, L Shi, BP Tu
Science signaling 7 (356), ra120, 2014
Methionine is a signal of amino acid sufficiency that inhibits autophagy through the methylation of PP2A
S Laxman, BM Sutter, BP Tu
Autophagy 10 (2), 386-387, 2014
The glyoxylate shunt is essential for desiccation tolerance in C. elegans and budding yeast
C Erkut, VR Gade, S Laxman, TV Kurzchalia
Elife 5, e13614, 2016
Trypanosome cyclic nucleotide phosphodiesterase 2B binds cAMP through its GAF-A domain
S Laxman, A Rascón, JA Beavo
Journal of Biological Chemistry 280 (5), 3771-3779, 2005
Decoding the stem cell quiescence cycle - lessons from yeast for regenerative biology.
J Dhawan, S Laxman
Journal of Cell Science 128 (24), 4467-74, 2015
Metabolite regulation of nuclear localization of carbohydrate-response element-binding protein (ChREBP) role of AMP as an allosteric inhibitor
S Sato, H Jung, T Nakagawa, R Pawlosky, T Takeshima, WR Lee, ...
Journal of Biological Chemistry 291 (20), 10515-10527, 2016
Regulation of hematopoiesis and methionine homeostasis by mTORC1 inhibitor NPRL2
PA Dutchak, S Laxman, SJ Estill, C Wang, Y Wang, Y Wang, GB Bulut, ...
Cell reports 12 (3), 371-379, 2015
Behavior of a metabolic cycling population at the single cell level as visualized by fluorescent gene expression reporters
S Laxman, BM Sutter, BP Tu
PloS one 5 (9), e12595, 2010
Multiple TORC1-associated proteins regulate nitrogen starvation-dependent cellular differentiation in Saccharomyces cerevisiae
S Laxman, BP Tu
PloS one 6 (10), e26081, 2011
Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi
R Díaz-Benjumea, S Laxman, TR Hinds, JA Beavo, A Rascón
Biochemical Journal 399 (2), 305-314, 2006
Methionine coordinates a hierarchically organized anabolic program enabling proliferation.
A Walvekar, R Srinivasan, R Gupta, S Laxman
Molecular Biology of the Cell, 2018
A versatile LC-MS/MS approach for comprehensive, quantitative analysis of central metabolic pathways
A Walvekar, Z Rashida, H Maddali, S Laxman
Wellcome open research 3, 2018
Systems approaches for the study of metabolic cycles in yeast
S Laxman, BP Tu
Current opinion in genetics & development 20 (6), 599-604, 2010
Metabolic constraints drive self-organization of specialized cell groups
S Varahan, A Walvekar, V Sinha, S Krishna, S Laxman
eLife 8, e46735, 2019
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