| Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis M Nguyen, RC Marcellus, A Roulston, M Watson, L Serfass, ... Proceedings of the National Academy of Sciences 104 (49), 19512-19517, 2007 | 803 | 2007 |
| Principles of microRNA regulation of a human cellular signaling network Q Cui, Z Yu, EO Purisima, E Wang Molecular systems biology 2 (1), 46, 2006 | 446 | 2006 |
| Solvated interaction energy (SIE) for scoring protein− ligand binding affinities. 1. Exploring the parameter space M Naïm, S Bhat, KN Rankin, S Dennis, SF Chowdhury, I Siddiqi, P Drabik, ... Journal of chemical information and modeling 47 (1), 122-133, 2007 | 411 | 2007 |
| Role of the occluding loop in cathepsin B activity C Illy, O Quraishi, J Wang, E Purisima, T Vernet, JS Mort Journal of Biological Chemistry 272 (2), 1197-1202, 1997 | 344 | 1997 |
| A map of human cancer signaling Q Cui, Y Ma, M Jaramillo, H Bari, A Awan, S Yang, S Zhang, L Liu, M Lu, ... Molecular systems biology 3 (1), 152, 2007 | 330 | 2007 |
| Identification of high-quality cancer prognostic markers and metastasis network modules J Li, AEG Lenferink, Y Deng, C Collins, Q Cui, EO Purisima, ... Nature communications 1 (1), 34, 2010 | 284 | 2010 |
| MicroRNAs preferentially target the genes with high transcriptional regulation complexity Q Cui, Z Yu, Y Pan, EO Purisima, E Wang Biochemical and biophysical research communications 352 (3), 733-738, 2007 | 167 | 2007 |
| A new tetrahedral tesselation scheme for isosurface generation SL Chan, EO Purisima Computers & Graphics 22 (1), 83-90, 1998 | 163 | 1998 |
| Molecular dynamics—Solvated interaction energy studies of protein–protein interactions: The MP1–p14 scaffolding complex Q Cui, T Sulea, JD Schrag, C Munger, MN Hung, M Naïm, M Cygler, ... Journal of molecular biology 379 (4), 787-802, 2008 | 160 | 2008 |
| Human cathepsin X: A cysteine protease with unique carboxypeptidase activity DK Nägler, R Zhang, W Tam, T Sulea, EO Purisima, R Ménard Biochemistry 38 (39), 12648-12654, 1999 | 156 | 1999 |
| A simple yet accurate boundary element method for continuum dielectric calculations EO Purisima, SH Nilar Journal of Computational Chemistry 16 (6), 681-689, 1995 | 156 | 1995 |
| Transcription factor substitution during the evolution of fungal ribosome regulation H Hogues, H Lavoie, A Sellam, M Mangos, T Roemer, E Purisima, ... Molecular cell 29 (5), 552-562, 2008 | 144 | 2008 |
| Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than … Z Yu, Z Jian, SH Shen, E Purisima, E Wang Nucleic acids research 35 (1), 152-164, 2007 | 141 | 2007 |
| Molecular formula analysis by an MS/MS/MS technique to expedite dereplication of natural products Y Konishi, T Kiyota, C Draghici, JM Gao, F Yeboah, S Acoca, ... Analytical chemistry 79 (3), 1187-1197, 2007 | 126 | 2007 |
| Deubiquitination, a new function of the severe acute respiratory syndrome coronavirus papain-like protease? T Sulea, HA Lindner, EO Purisima, R Ménard Journal of virology 79 (7), 4550-4551, 2005 | 121 | 2005 |
| Fast summation boundary element method for calculating solvation free energies of macromolecules EO Purisima Journal of Computational Chemistry 19 (13), 1494-1504, 1998 | 121 | 1998 |
| An approach to the multiple-minima problem in protein folding by relaxing dimensionality: Tests on enkephalin EO Purisima, HA Scheraga Journal of Molecular Biology 196 (3), 697-709, 1987 | 120 | 1987 |
| An approach to the multiple-minima problem by relaxing dimensionality. EO Purisima, HA Scheraga Proceedings of the National Academy of Sciences 83 (9), 2782-2786, 1986 | 96 | 1986 |
| Alterations in the α2 isoform of Na, K-ATPase associated with familial hemiplegic migraine type 2 L Segall, A Mezzetti, R Scanzano, JJ Gargus, E Purisima, R Blostein Proceedings of the National Academy of Sciences 102 (31), 11106-11111, 2005 | 95 | 2005 |
| Design of noncovalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides SF Chowdhury, J Sivaraman, J Wang, G Devanathan, P Lachance, H Qi, ... Journal of medicinal chemistry 45 (24), 5321-5329, 2002 | 95 | 2002 |
