| Acid pH in tumors and its potential for therapeutic exploitation IF Tannock, D Rotin Cancer research 49 (16), 4373-4384, 1989 | 2188 | 1989 |
| Physiological functions of the HECT family of ubiquitin ligases D Rotin, S Kumar Nature reviews Molecular cell biology 10 (6), 398-409, 2009 | 1283 | 2009 |
| WW domains of Nedd4 bind to the proline‐rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. O Staub, S Dho, P Henry, J Correa, T Ishikawa, J McGlade, D Rotin The EMBO journal 15 (10), 2371-2380, 1996 | 1041 | 1996 |
| Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation S Grinstein, D Rotin, MJ Mason Biochimica et Biophysica Acta (BBA)-Reviews on Biomembranes 988 (1), 73-97, 1989 | 968 | 1989 |
| Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination O Staub, I Gautschi, T Ishikawa, K Breitschopf, A Ciechanover, L Schild, ... The EMBO journal, 1997 | 872 | 1997 |
| Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor AG Batzer, D Rotin, JM Urena, EY Skolnik, J Schlessinger Molecular and cellular biology, 1994 | 664 | 1994 |
| A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-γ1 M Mohammadi, AM Honegger, D Rotin, R Fischer, F Bellot, W Li, ... Molecular and cellular biology, 1991 | 577 | 1991 |
| Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases D Rotin, O Staub, R Haguenauer-Tsapis The Journal of membrane biology 176, 1-17, 2000 | 485 | 2000 |
| SH3 domains direct cellular localization of signaling molecules D Bar-Sagi, D Rotin, A Batzer, V Mandiyan, J Schlessinger Cell 74 (1), 83-91, 1993 | 468 | 1993 |
| Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome H Abriel, J Loffing, JF Rebhun, JH Pratt, L Schild, JD Horisberger, D Rotin, ... The Journal of clinical investigation 103 (5), 667-673, 1999 | 449 | 1999 |
| SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high‐affinity binding site for SH2 domains of phospholipase C gamma. D Rotin, B Margolis, M Mohammadi, RJ Daly, G Daum, N Li, EH Fischer, ... The EMBO journal 11 (2), 559-567, 1992 | 377 | 1992 |
| Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain S Wiesner, AA Ogunjimi, HR Wang, D Rotin, F Sicheri, JL Wrana, ... Cell 130 (4), 651-662, 2007 | 324 | 2007 |
| A strategy for modulation of enzymes in the ubiquitin system A Ernst, G Avvakumov, J Tong, Y Fan, Y Zhao, P Alberts, A Persaud, ... Science 339 (6119), 590-595, 2013 | 312 | 2013 |
| The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor A Vecchione, A Marchese, P Henry, D Rotin, A Morrione Molecular and cellular biology 23 (9), 3363-3372, 2003 | 297 | 2003 |
| Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination O Staub, H Abriel, P Plant, T Ishikawa, V Kanelis, R Saleki, ... Kidney international 57 (3), 809-815, 2000 | 279 | 2000 |
| An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane. D Rotin, D Bar‐Sagi, H O'brodovich, J Merilainen, VP Lehto, CM Canessa, ... The EMBO journal 13 (19), 4440-4450, 1994 | 277 | 1994 |
| Activation of the Na+/H+ antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism. S Grinstein, M Woodside, C Sardet, J Pouyssegur, D Rotin Journal of Biological Chemistry 267 (33), 23823-23828, 1992 | 274 | 1992 |
| Role of ubiquitylation in cellular membrane transport O Staub, D Rotin Physiological reviews 86 (2), 669-707, 2006 | 271 | 2006 |
| Solution structure of a Nedd4 WW domain–ENaC peptide complex V Kanelis, D Rotin, JD Forman-Kay Nature structural biology 8 (5), 407-412, 2001 | 263 | 2001 |
| Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants. L Fialkow, CK Chan, D Rotin, S Grinstein, GP Downey Journal of Biological Chemistry 269 (49), 31234-31242, 1994 | 257 | 1994 |
