Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors AS Trigos, RB Pearson, AT Papenfuss, DL Goode Proceedings of the National Academy of Sciences 114 (24), 6406-6411, 2017 | 188 | 2017 |
How the evolution of multicellularity set the stage for cancer AS Trigos, RB Pearson, AT Papenfuss, DL Goode British journal of cancer 118 (2), 145-152, 2018 | 130 | 2018 |
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer E Sanij, KM Hannan, J Xuan, S Yan, JE Ahern, AS Trigos, N Brajanovski, ... Nature communications 11 (1), 2641, 2020 | 114 | 2020 |
Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer AS Trigos, RB Pearson, AT Papenfuss, DL Goode Elife 8, e40947, 2019 | 65 | 2019 |
A functional genetic screen defines the AKT-induced senescence signaling network KT Chan, S Blake, H Zhu, J Kang, AS Trigos, PB Madhamshettiwar, ... Cell Death & Differentiation 27 (2), 725-741, 2020 | 48 | 2020 |
Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis EP Kusnadi, AS Trigos, C Cullinane, DL Goode, O Larsson, JR Devlin, ... The EMBO Journal 39 (21), e105111, 2020 | 18 | 2020 |
Spatial analysis with SPIAT and spaSim to characterize and simulate tissue microenvironments Y Feng, T Yang, J Zhu, M Li, M Doyle, V Ozcoban, GT Bass, A Pizzolla, ... Nature Communications 14 (1), 2697, 2023 | 16 | 2023 |
Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation H Zhu, KT Chan, X Huang, C Cerra, S Blake, AS Trigos, D Anderson, ... Elife 11, e71929, 2022 | 12 | 2022 |
Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma LK Smith, T Parmenter, M Kleinschmidt, EP Kusnadi, J Kang, CA Martin, ... Nature Communications 13 (1), 1100, 2022 | 9 | 2022 |
Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells E Gruber, J So, AC Lewis, R Franich, R Cole, LG Martelotto, AJ Rogers, ... Cell Reports 40 (7), 2022 | 7 | 2022 |
Tumor immune microenvironment of primary prostate cancer with and without germline mutations in homologous recombination repair genes AS Trigos, A Pasam, P Banks, R Wallace, C Guo, S Keam, H Thorne, ... Journal for Immunotherapy of Cancer 10 (6), 2022 | 7 | 2022 |
SPIAT: an R package for the spatial image analysis of cells in tissues T Yang, V Ozcoban, A Pasam, N Kocovski, A Pizzolla, YK Huang, G Bass, ... bioRxiv, 2020.05. 28.122614, 2020 | 7 | 2020 |
Comprehensive profiling identifies tumour and immune microenvironmental differences in clinical subsets of cutaneous squamous cell carcinoma AA Thai, RJ Young, M Bressel, C Angel, L McDowell, A Tiong, ... British Journal of Dermatology 189 (5), 588-602, 2023 | 3 | 2023 |
RNA‐seq analysis in R B Phipson, A Trigos, M Ritchie, S Su, M Doyle, H Dashnow, C Law | 3 | 2020 |
Disruption of metazoan gene regulatory networks in cancer alters the balance of co-expression between genes of unicellular and multicellular origins AS Trigos, F Bongiovanni, M Zethoven, R Tothill, R Pearson, T Papenfuss, ... bioRxiv, 2023.04. 20.537744, 2023 | 2 | 2023 |
Collateral sensitivity to β-lactam drugs in drug-resistant tuberculosis is driven by the transcriptional wiring of BlaI operon genes AS Trigos, BW Goudey, J Bedő, TC Conway, NG Faux, KL Wyres Msphere 6 (3), 10.1128/msphere. 00245-21, 2021 | 2 | 2021 |
Inhibition of RNA polymerase I transcription activates targeted DNA damage response and enhances the efficacy of PARP inhibitors in high-grade serous ovarian cancer E Sanij, KM Hannan, S Yan, J Xuan, JE Ahern, KT Chan, J Son, ... bioRxiv, 621623, 2019 | 2 | 2019 |
Hands-on: Hands-on: 2: RNA-seq counts to genes M Doyle, B Phipson, J Maksimovic, A Trigos, M Ritchie, H Dashnow, S Su, ... Galaxy Training Network, 2024 | 1 | 2024 |
Heterogeneity of canonical prostate cancer markers across lesions in metastatic castration-resistant prostate cancer. AS Trigos, A Pasam, AJ Inderjeeth, LD Cain, S Weng, V Gupta, B Sable, ... Journal of Clinical Oncology 41 (6_suppl), 219-219, 2023 | 1 | 2023 |
668 A toolkit for the quantitative analysis of the spatial distribution of cells of the tumor immune microenvironment A Trigos, T Yang, Y Feng, V Ozcoban, M Doyle, A Pasam, N Kocovski, ... Journal for ImmunoTherapy of Cancer 8 (Suppl 3), 2020 | 1 | 2020 |