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| Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1 J Kong, Z Xu Journal of Neuroscience 18 (9), 3241-3250, 1998 | 870 | 1998 |
| Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. DR Borchelt, MK Lee, HS Slunt, M Guarnieri, ZS Xu, PC Wong, ... Proceedings of the National Academy of Sciences 91 (17), 8292-8296, 1994 | 788 | 1994 |
| Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis CH Wu, C Fallini, N Ticozzi, PJ Keagle, PC Sapp, K Piotrowska, P Lowe, ... Nature 488 (7412), 499-503, 2012 | 724 | 2012 |
| Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease Z Xu, LC Cork, JW Griffin, DW Cleveland Cell 73 (1), 23-33, 1993 | 668 | 1993 |
| Neurofilaments are obligate heteropolymers in vivo MK Lee, Z Xu, PC Wong, DW Cleveland The Journal of cell biology 122 (6), 1337-1350, 1993 | 473 | 1993 |
| Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons. CA Pardo, Z Xu, DR Borchelt, DL Price, SS Sisodia, DW Cleveland Proceedings of the National Academy of Sciences 92 (4), 954-958, 1995 | 427 | 1995 |
| Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model H Kikuchi, G Almer, S Yamashita, C Guégan, M Nagai, Z Xu, AA Sosunov, ... Proceedings of the National Academy of Sciences 103 (15), 6025-6030, 2006 | 384 | 2006 |
| Designing siRNA that distinguish between genes that differ by a single nucleotide DS Schwarz, H Ding, L Kennington, JT Moore, J Schelter, J Burchard, ... PLoS genetics 2 (9), e140, 2006 | 349 | 2006 |
| Reactive astrocytes secrete lcn2 to promote neuron death F Bi, C Huang, J Tong, G Qiu, B Huang, Q Wu, F Li, Z Xu, R Bowser, ... Proceedings of the National Academy of Sciences 110 (10), 4069-4074, 2013 | 334 | 2013 |
| Several rAAV vectors efficiently cross the blood–brain barrier and transduce neurons and astrocytes in the neonatal mouse central nervous system H Zhang, B Yang, X Mu, SS Ahmed, Q Su, R He, H Wang, C Mueller, ... Molecular Therapy 19 (8), 1440-1448, 2011 | 330 | 2011 |
| ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and … CMJ Higgins, C Jung, Z Xu BMC neuroscience 4, 1-14, 2003 | 323 | 2003 |
| Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS CMJ Higgins, C Jung, H Ding, Z Xu | 298 | 2002 |
| Regional modulation of neurofilament organization by myelination in normal axons ST Hsieh, GJ Kidd, TO Crawford, Z Xu, WM Lin, BD Trapp, DW Cleveland, ... Journal of Neuroscience 14 (11), 6392-6401, 1994 | 282 | 1994 |
| Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M DL Dong, ZS Xu, MR Chevrier, RJ Cotter, DW Cleveland, GW Hart Journal of Biological Chemistry 268 (22), 16679-16687, 1993 | 265 | 1993 |
| Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis C Jung, CMJ Higgins, Z Xu Journal of neurochemistry 83 (3), 535-545, 2002 | 261 | 2002 |
| Allele-specific RNA interference Z Xu, P Zamore US Patent App. 10/700,816, 2004 | 250 | 2004 |
| Mitochondrial dysfunction and its role in motor neuron degeneration in ALS G Manfredi, Z Xu Mitochondrion 5 (2), 77-87, 2005 | 247 | 2005 |
| Global CNS transduction of adult mice by intravenously delivered rAAVrh. 8 and rAAVrh. 10 and nonhuman primates by rAAVrh. 10 B Yang, S Li, H Wang, Y Guo, DJ Gessler, C Cao, Q Su, J Kramer, ... Molecular Therapy 22 (7), 1299-1309, 2014 | 246 | 2014 |
| An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi H Zhou, XG Xia, Z Xu Nucleic acids research 33 (6), e62-e62, 2005 | 233 | 2005 |
Don W ClevelandUniversity of California at San DiegoVerified email at UCSD.EDU
