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Rozbeh Jafari
Rozbeh Jafari
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Year
Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay
DM Molina, R Jafari, M Ignatushchenko, T Seki, EA Larsson, C Dan, ...
Science 341 (6141), 84-87, 2013
16932013
The cellular thermal shift assay for evaluating drug target interactions in cells
R Jafari, H Almqvist, H Axelsson, M Ignatushchenko, T Lundbäck, ...
Nature protocols 9 (9), 2100-2122, 2014
10702014
Tracking cancer drugs in living cells by thermal profiling of the proteome
MM Savitski, FBM Reinhard, H Franken, T Werner, MF Savitski, ...
Science 346 (6205), 1255784, 2014
9812014
Functional mapping and single chain construction of the anti-cytokeratin 8 monoclonal antibody TS1
P Holm, R Jafari, BE Sundström
Molecular Immunology 44 (6), 1075-1084, 2007
3222007
CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
H Almqvist, H Axelsson, R Jafari, C Dan, A Mateus, M Haraldsson, ...
Nature communications 7 (1), 11040, 2016
1532016
Validation and development of MTH1 inhibitors for treatment of cancer
UW Berglund, K Sanjiv, H Gad, C Kalderen, T Koolmeister, T Pham, ...
Annals of oncology 27 (12), 2275-2283, 2016
1392016
Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia
M Yang, M Vesterlund, I Siavelis, LH Moura-Castro, A Castor, T Fioretos, ...
Nature communications 10 (1), 1519, 2019
722019
Optimization of production of the anti-keratin 8 single-chain Fv TS1-218 in Pichia pastoris using design of experiments
R Jafari, BE Sundström, P Holm
Microbial cell factories 10, 1-8, 2011
412011
Novel broad-spectrum antiviral inhibitors targeting host factors essential for replication of pathogenic RNA viruses
M Tampere, A Pettke, C Salata, O Wallner, T Koolmeister, ...
Viruses 12 (12), 1423, 2020
262020
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines
IR Leo, L Aswad, M Stahl, E Kunold, F Post, T Erkers, N Struyf, ...
Nature Communications 13 (1), 1691, 2022
242022
Proteogenomics refines the molecular classification of chronic lymphocytic leukemia
SA Herbst, M Vesterlund, AJ Helmboldt, R Jafari, I Siavelis, M Stahl, ...
Nature Communications 13 (1), 6226, 2022
212022
Construction of divalent anti-keratin 8 single-chain antibodies (sc (Fv) 2), expression in Pichia pastoris and their reactivity with multicellular tumor spheroids
R Jafari, P Holm, M Piercecchi, BE Sundström
Journal of immunological methods 364 (1-2), 65-76, 2011
182011
Preclinical efficacy of azacitidine and venetoclax for infant KMT2A-rearranged acute lymphoblastic leukemia reveals a new therapeutic strategy
LC Cheung, C Aya-Bonilla, MN Cruickshank, SK Chiu, V Kuek, ...
Leukemia 37 (1), 61-71, 2023
142023
Deep thermal profiling for detection of functional proteoform groups
N Kurzawa, IR Leo, M Stahl, E Kunold, I Becher, A Audrey, G Mermelekas, ...
Nature Chemical Biology 19 (8), 962-971, 2023
132023
Thermal proteome profiling identifies PIP4K2A and ZADH2 as off‐targets of Polo‐like kinase 1 inhibitor volasertib
O Goroshchuk, I Kolosenko, E Kunold, L Vidarsdottir, M Pirmoradian, ...
The FASEB Journal 35 (7), e21741, 2021
92021
The transcriptome‐wide landscape of molecular subtype‐specific mRNA expression profiles in acute myeloid leukemia
T Mou, Y Pawitan, M Stahl, M Vesterlund, W Deng, R Jafari, A Bohlin, ...
American Journal of hematology 96 (5), 580-588, 2021
82021
Localization of complexed anticytokeratin 8 scFv TS1-218 to HeLa HEp-2 multicellular tumor spheroids and experimental tumors
R Jafari, P Holm, J Sandegren, T Stigbrand, BE Sundström
Cancer biotherapy & radiopharmaceuticals 25 (4), 455-463, 2010
52010
Deep thermal proteome profiling for detection of proteoforms and drug sensitivity biomarkers
N Kurzawa, M Stahl, I Leo, E Kunold, I Becher, A Audrey, G Mermelekas, ...
bioRxiv, 2022.06. 10.495491, 2022
22022
Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound
TA Giovannucci, FA Salomons, M Haraldsson, LHM Elfman, M Wickström, ...
Cell Death & Disease 12 (10), 914, 2021
22021
Prediction model for drug response of acute myeloid leukemia patients
QT Trac, Y Pawitan, T Mou, T Erkers, P Östling, A Bohlin, A Österroos, ...
NPJ Precision Oncology 7 (1), 32, 2023
12023
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