| Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway NV Oleinik, NI Krupenko, SA Krupenko Oncogene 26 (51), 7222-7230, 2007 | 155 | 2007 |
| Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase CL Elmore, X Wu, D Leclerc, ED Watson, T Bottiglieri, NI Krupenko, ... Molecular genetics and metabolism 91 (1), 85-97, 2007 | 128 | 2007 |
| ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase NI Krupenko, ME Dubard, KC Strickland, KM Moxley, NV Oleinik, ... Journal of biological chemistry 285 (30), 23056-23063, 2010 | 103 | 2010 |
| ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A NV Oleinik, NI Krupenko, SA Krupenko Oncogene 29 (47), 6233-6244, 2010 | 90 | 2010 |
| C16-ceramide is a natural regulatory ligand of p53 in cellular stress response B Fekry, KA Jeffries, A Esmaeilniakooshkghazi, ZM Szulc, KJ Knagge, ... Nature communications 9 (1), 4149, 2018 | 88 | 2018 |
| Molecular mechanisms underlying the potentially adverse effects of folate KC Strickland, NI Krupenko, SA Krupenko Clinical chemistry and laboratory medicine 51 (3), 607-616, 2013 | 82 | 2013 |
| Interaction of sex hormone-binding globulin with plasma membranes from the rat epididymis and other tissues SA Krupenko, NI Krupenko, BJ Danzo The Journal of steroid biochemistry and molecular biology 51 (1-2), 115-124, 1994 | 77 | 1994 |
| Crystal structures of the carboxyl terminal domain of rat 10-formyltetrahydrofolate dehydrogenase: implications for the catalytic mechanism of aldehyde dehydrogenases Y Tsybovsky, H Donato, NI Krupenko, C Davies, SA Krupenko Biochemistry 46 (11), 2917-2929, 2007 | 74 | 2007 |
| Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6 LA Hoeferlin, B Fekry, B Ogretmen, SA Krupenko, NI Krupenko Journal of Biological Chemistry 288 (18), 12880-12890, 2013 | 72 | 2013 |
| Epigenetic silencing of ALDH1L1, a metabolic regulator of cellular proliferation, in cancers NV Oleinik, NI Krupenko, SA Krupenko Genes & Cancer 2 (2), 130-139, 2011 | 72 | 2011 |
| Activation of p21-dependent G1/G2 arrest in the absence of DNA damage as an antiapoptotic response to metabolic stress LA Hoeferlin, NV Oleinik, NI Krupenko, SA Krupenko Genes & cancer 2 (9), 889-899, 2011 | 68 | 2011 |
| Pteridine–sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity SM Marques, ÉA Enyedy, CT Supuran, NI Krupenko, SA Krupenko, ... Bioorganic & medicinal chemistry 18 (14), 5081-5089, 2010 | 63 | 2010 |
| The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line S Chattopadhyay, R Zhao, SA Krupenko, N Krupenko, ID Goldman Molecular cancer therapeutics 5 (2), 438-449, 2006 | 61 | 2006 |
| Ceramide signaling and p53 pathways KA Jeffries, NI Krupenko Advances in cancer research 140, 191-215, 2018 | 59 | 2018 |
| Rho GTPases RhoA and Rac1 mediate effects of dietary folate on metastatic potential of A549 cancer cells through the control of cofilin phosphorylation NV Oleinik, KL Helke, E Kistner-Griffin, NI Krupenko, SA Krupenko Journal of Biological Chemistry 289 (38), 26383-26394, 2014 | 55 | 2014 |
| ALDH1L1 and ALDH1L2 folate regulatory enzymes in cancer SA Krupenko, NI Krupenko Alcohol and Cancer: Proceedings of the Third International Conference, 127-143, 2018 | 52 | 2018 |
| Cancer cells activate p53 in response to 10-formyltetrahydrofolate dehydrogenase expression NV Oleinik, NI Krupenko, DG Priest, SA Krupenko Biochemical Journal 391 (3), 503-511, 2005 | 51 | 2005 |
| Ceramide synthase 6 is a novel target of methotrexate mediating its antiproliferative effect in a p53-dependent manner B Fekry, A Esmaeilniakooshkghazi, SA Krupenko, NI Krupenko PLoS One 11 (1), e0146618, 2016 | 49 | 2016 |
| A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development KE Christensen, L Deng, KY Leung, E Arning, T Bottiglieri, OV Malysheva, ... Human molecular genetics 22 (18), 3705-3719, 2013 | 48 | 2013 |
| CerS6 is a novel transcriptional target of p53 protein activated by non-genotoxic stress B Fekry, KA Jeffries, A Esmaeilniakooshkghazi, B Ogretmen, ... Journal of Biological Chemistry 291 (32), 16586-16596, 2016 | 47 | 2016 |
