| Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents V Mody, J Ho, S Wills, A Mawri, L Lawson, MC Ebert, GM Fortin, ... Communications biology 4 (1), 93, 2021 | 219 | 2021 |
| Roles of TRPM2 in oxidative stress N Takahashi, D Kozai, R Kobayashi, M Ebert, Y Mori Cell calcium 50 (3), 279-287, 2011 | 189 | 2011 |
| Computational tools for enzyme improvement: why everyone can–and should–use them MC Ebert, JN Pelletier Current opinion in chemical biology 37, 89-96, 2017 | 100 | 2017 |
| O2-dependent protein internalization underlies astrocytic sensing of acute hypoxia by restricting multimodal TRPA1 channel responses M Uchiyama, A Nakao, Y Kurita, I Fukushi, K Takeda, T Numata, HN Tran, ... Current Biology 30 (17), 3378-3396. e7, 2020 | 30 | 2020 |
| Enzyme engineering: A synthetic biology approach for more effective library generation and automated high-throughput screening D Quaglia, MC Ebert, PF Mugford, JN Pelletier PLoS One 12 (2), e0171741, 2017 | 28 | 2017 |
| Transnitrosylation directs TRPA1 selectivity in N-nitrosamine activators D Kozai, Y Kabasawa, M Ebert, S Kiyonaka, Y Otani, T Numata, ... Molecular pharmacology 85 (1), 175-185, 2014 | 28 | 2014 |
| Fragment-based design of symmetrical bis-benzimidazoles as selective inhibitors of the trimethoprim-resistant, type II R67 dihydrofolate reductase D Bastien, MC Ebert, D Forge, J Toulouse, N Kadnikova, F Perron, ... Journal of Medicinal Chemistry 55 (7), 3182-3192, 2012 | 28 | 2012 |
| Aloin isoforms (A and B) selectively inhibits proteolytic and deubiquitinating activity of papain like protease (PLpro) of SARS-CoV-2 in vitro DSM Lewis, J Ho, S Wills, A Kawall, A Sharma, K Chavada, MC Ebert, ... Scientific reports 12 (1), 2145, 2022 | 27 | 2022 |
| The structural dynamics of engineered β-lactamases vary broadly on three timescales yet sustain native function SMC Gobeil, MC Ebert, J Park, D Gagné, N Doucet, AM Berghuis, J Pleiss, ... Scientific Reports 9 (1), 6656, 2019 | 22 | 2019 |
| Substrate-specific screening for mutational hotspots using biased molecular dynamics simulations MC Ebert, J Guzman Espinola, G Lamoureux, JN Pelletier Acs Catalysis 7 (10), 6786-6797, 2017 | 21 | 2017 |
| Evolution of P450 monooxygenases toward formation of transient channels and exclusion of nonproductive gases MC Ebert, SL Dürr, A A. Houle, G Lamoureux, JN Pelletier Acs Catalysis 6 (11), 7426-7437, 2016 | 21 | 2016 |
| Monitoring protein conformational changes using fluorescent nanoantennas SG Harroun, D Lauzon, MC Ebert, A Desrosiers, X Wang, A Vallée-Bélisle Nature Methods 19 (1), 71-80, 2022 | 19 | 2022 |
| AMBER free energy tools: a new framework for the design of optimized alchemical transformation pathways HC Tsai, TS Lee, A Ganguly, TJ Giese, MC Ebert, P Labute, KM Merz Jr, ... Journal of Chemical Theory and Computation 19 (2), 640-658, 2023 | 15 | 2023 |
| Indigo formation and rapid NADPH consumption provide robust prediction of raspberry ketone synthesis by engineered cytochrome P450 BM3 O Rousseau, MC Ebert, D Quaglia, A Fendri, AH Parisien, JN Besna, ... ChemCatChem 12 (3), 837-845, 2020 | 15 | 2020 |
| Dual-target inhibitors of the folate pathway inhibit intrinsically trimethoprim-resistant DfrB dihydrofolate reductases JL Toulouse, G Shi, C Lemay-St-Denis, MC Ebert, D Deon, M Gagnon, ... ACS medicinal chemistry letters 11 (11), 2261-2267, 2020 | 11 | 2020 |
| Asymmetric mutations in the tetrameric R67 dihydrofolate reductase reveal high tolerance to active‐site substitutions MC Ebert, KL Morley, JP Volpato, AR Schmitzer, JN Pelletier Protein Science 24 (4), 495-507, 2015 | 11 | 2015 |
| Novel crystallization conditions for tandem variant R67 DHFR yield a wild-type crystal structure BJ Yachnin, DY Colin, JP Volpato, M Ebert, JN Pelletier, AM Berghuis Acta Crystallographica Section F: Structural Biology and Crystallization …, 2011 | 9 | 2011 |
| Structure-based design of dimeric bisbenzimidazole inhibitors to an emergent trimethoprim-resistant type II dihydrofolate reductase guides the design of monomeric analogues JL Toulouse, BJ Yachnin, EH Ruediger, D Deon, M Gagnon, ... ACS omega 4 (6), 10056-10069, 2019 | 8 | 2019 |
| ATP synthase: a moonlighting enzyme with unprecedented functions JN Vigneau, P Fahimi, M Ebert, Y Cheng, C Tannahill, P Muir, ... Chemical Communications 58 (16), 2650-2653, 2022 | 6 | 2022 |
| Functional antibody characterization via direct structural analysis and information‐driven protein‐protein docking RS Depetris, D Lu, Z Polonskaya, Z Zhang, X Luna, A Tankard, P Kolahi, ... Proteins: Structure, Function, and Bioinformatics, 2021 | 6 | 2021 |
