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Simon A. Hinke, Ph.D.
Simon A. Hinke, Ph.D.
Principal Scientist, Janssen Pharmaceutical Companies of J&J
Verified email at uw.edu - Homepage
Title
Cited by
Cited by
Year
Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors
T Hansotia, LL Baggio, D Delmeire, SA Hinke, Y Yamada, K Tsukiyama, ...
Diabetes 53 (5), 1326-1335, 2004
3802004
Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1
SA Hinke, K Kühn-Wache, T Hoffmann, RA Pederson, CHS McIntosh, ...
Biochemical and biophysical research communications 291 (5), 1302-1308, 2002
2142002
Dipeptidyl peptidase IV (DPIV/CD26) degradation of glucagon: characterization of glucagon degradation products and DPIV-resistant analogs
SA Hinke, JA Pospisilik, HU Demuth, S Mannhart, K Kuhn-Wache, ...
Journal of Biological Chemistry 275 (6), 3827-3834, 2000
1562000
Glucose suppresses superoxide generation in metabolically responsive pancreatic β cells
GA Martens, Y Cai, S Hinke, G Stangé, M Van de Casteele, D Pipeleers
Journal of biological chemistry 280 (21), 20389-20396, 2005
1532005
Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis
N Pamir, FC Lynn, AMJ Buchan, J Ehses, SA Hinke, JA Pospisilik, ...
American Journal of Physiology-Endocrinology and Metabolism 284 (5), E931-E939, 2003
1532003
Dipeptidyl peptidase IV-resistant [D-Ala2] glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats
SA Hinke, RW Gelling, RA Pederson, S Manhart, C Nian, HU Demuth, ...
Diabetes 51 (3), 652-661, 2002
1492002
Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1
D Delmeire, D Flamez, SA Hinke, JJ Cali, D Pipeleers, F Schuit
Diabetologia 46, 1383-1393, 2003
1342003
Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation
Y Cai, GA Martens, SA Hinke, H Heimberg, D Pipeleers, ...
Free Radical Biology and Medicine 42 (1), 64-78, 2007
1312007
A novel pathway for regulation of glucose‐dependent insulinotropic polypeptide receptor expression in β‐cells
FC Lynn, SA Thompson, JA Pospisilik, JA Ehses, SA Hinke, N Pamir, ...
The FASEB Journal 17 (1), 91-93, 2003
1182003
AKAP150 Contributes to Enhanced Vascular Tone by Facilitating Large-Conductance Ca2+-Activated K+ Channel Remodeling in Hyperglycemia and Diabetes …
MA Nystoriak, M Nieves-Cintrón, PJ Nygren, SA Hinke, CB Nichols, ...
Circulation Research 114 (4), 607-615, 2014
1172014
Metabolism of glucagon by dipeptidyl peptidase IV (CD26)
JA Pospisilik, SA Hinke, RA Pederson, T Hoffmann, F Rosche, ...
Regulatory peptides 96 (3), 133-141, 2001
1082001
Methyl succinate antagonises biguanide‐induced AMPK‐activation and death of pancreatic β‐cells through restoration of mitochondrial electron transfer
SA Hinke, GA Martens, Y Cai, J Finsi, H Heimberg, D Pipeleers, ...
British journal of pharmacology 150 (8), 1031-1043, 2007
1032007
Identification of a bioactive domain in the amino-terminus of glucose-dependent insulinotropic polypeptide (GIP)
SA Hinke, S Manhart, N Pamir, HU Demuth, RW Gelling, RA Pederson, ...
Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular …, 2001
982001
Glucose-dependent insulinotropic polypeptide stimulation of lipolysis in differentiated 3T3-L1 cells: wortmannin-sensitive inhibition by insulin
CHS McIntosh, I Bremsak, FC Lynn, R Gill, SA Hinke, R Gelling, C Nian, ...
Endocrinology 140 (1), 398-404, 1999
931999
GIP6–30amide contains the high affinity binding region of GIP and is a potent inhibitor of GIP1–42action in vitro
RW Gelling, DH Coy, RA Pederson, MB Wheeler, S Hinke, T Kwan, ...
Regulatory peptides 69 (3), 151-154, 1997
891997
Anchored phosphatases modulate glucose homeostasis
SA Hinke, MF Navedo, A Ulman, JL Whiting, PJ Nygren, G Tian, ...
The EMBO journal 31 (20), 3991-4004, 2012
792012
Plasticity of the β cell insulin secretory competence: preparing the pancreatic β cell for the next meal
SA Hinke, K Hellemans, FC Schuit
The Journal of Physiology 558 (2), 369-380, 2004
782004
On combination therapy of diabetes with metformin and dipeptidyl peptidase IV inhibitors/Response to Hinke et al.
SA Hinke, CHS McIntosh, T Hoffmann, K Kühn-Wache
Diabetes Care 25 (8), 1490, 2002
712002
MyRIP anchors protein kinase A to the exocyst complex
AS Goehring, BS Pedroja, SA Hinke, LK Langeberg, JD Scott
Journal of biological chemistry 282 (45), 33155-33167, 2007
542007
Characterization of the carboxyl-terminal domain of the rat glucose-dependent insulinotropic polypeptide (GIP) receptor: a role for serines 426 and 427 in regulating the rate …
MB Wheeler, RW Gelling, SA Hinke, B Tu, RA Pederson, F Lynn, J Ehses, ...
Journal of Biological Chemistry 274 (35), 24593-24601, 1999
481999
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